(20 nodes) Vitamin B5 (pantothenate) metabolism network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000001872	Dynein light chain. (124 aa)
	ENSUAMP00000002512	Uncharacterized protein. (197 aa)
	SLC5A6	Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (638 aa)
	COASY	Coenzyme A synthase. (560 aa)
	ENSUAMP00000010000	Uncharacterized protein. (245 aa)
	ENSUAMP00000010002	Uncharacterized protein. (220 aa)
	PPCS	Phosphopantothenoylcysteine synthetase. (310 aa)
	ENSUAMP00000011405	Uncharacterized protein. (482 aa)
	VNN1	Vanin 1. (483 aa)
	ENSUAMP00000019626	Dynein light chain. (127 aa)
	ENSUAMP00000020855	Uncharacterized protein. (512 aa)
	DCAKD	Dephospho-CoA kinase domain containing. (231 aa)
	PPCDC	Phosphopantothenoylcysteine decarboxylase. (204 aa)
	PDZD11	PDZ domain containing 11. (140 aa)
	PANK3	Pantothenate kinase 3. (368 aa)
	FASN	Fatty acid synthase. (2519 aa)
	PANK4	4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. (789 aa)
	SLC25A16	Solute carrier family 25 member 16; Belongs to the mitochondrial carrier (TC 2.A.29) family. (330 aa)
	AASDHPPT	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
	PANK2	Pantothenate kinase 2. (451 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASDHPPT	COASY	ENSUAMP00000001084	ENSUAMP00000008730	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.	Coenzyme A synthase.	0.951
AASDHPPT	DCAKD	ENSUAMP00000001084	ENSUAMP00000023093	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.	Dephospho-CoA kinase domain containing.	0.528
AASDHPPT	FASN	ENSUAMP00000001084	ENSUAMP00000032595	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.	Fatty acid synthase.	0.983
AASDHPPT	PANK2	ENSUAMP00000001084	ENSUAMP00000035481	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.	Pantothenate kinase 2.	0.448
AASDHPPT	PANK3	ENSUAMP00000001084	ENSUAMP00000030355	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.	Pantothenate kinase 3.	0.536
COASY	AASDHPPT	ENSUAMP00000008730	ENSUAMP00000001084	Coenzyme A synthase.	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.	0.951
COASY	DCAKD	ENSUAMP00000008730	ENSUAMP00000023093	Coenzyme A synthase.	Dephospho-CoA kinase domain containing.	0.814
COASY	ENSUAMP00000002512	ENSUAMP00000008730	ENSUAMP00000002512	Coenzyme A synthase.	Uncharacterized protein.	0.968
COASY	ENSUAMP00000010000	ENSUAMP00000008730	ENSUAMP00000010000	Coenzyme A synthase.	Uncharacterized protein.	0.914
COASY	ENSUAMP00000010002	ENSUAMP00000008730	ENSUAMP00000010002	Coenzyme A synthase.	Uncharacterized protein.	0.914
COASY	ENSUAMP00000011405	ENSUAMP00000008730	ENSUAMP00000011405	Coenzyme A synthase.	Uncharacterized protein.	0.741
COASY	ENSUAMP00000020855	ENSUAMP00000008730	ENSUAMP00000020855	Coenzyme A synthase.	Uncharacterized protein.	0.741
COASY	FASN	ENSUAMP00000008730	ENSUAMP00000032595	Coenzyme A synthase.	Fatty acid synthase.	0.505
COASY	PANK2	ENSUAMP00000008730	ENSUAMP00000035481	Coenzyme A synthase.	Pantothenate kinase 2.	0.978
COASY	PANK3	ENSUAMP00000008730	ENSUAMP00000030355	Coenzyme A synthase.	Pantothenate kinase 3.	0.968
COASY	PANK4	ENSUAMP00000008730	ENSUAMP00000034355	Coenzyme A synthase.	4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway.	0.979
COASY	PPCDC	ENSUAMP00000008730	ENSUAMP00000024115	Coenzyme A synthase.	Phosphopantothenoylcysteine decarboxylase.	0.977
COASY	PPCS	ENSUAMP00000008730	ENSUAMP00000010005	Coenzyme A synthase.	Phosphopantothenoylcysteine synthetase.	0.915
DCAKD	AASDHPPT	ENSUAMP00000023093	ENSUAMP00000001084	Dephospho-CoA kinase domain containing.	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.	0.528
DCAKD	COASY	ENSUAMP00000023093	ENSUAMP00000008730	Dephospho-CoA kinase domain containing.	Coenzyme A synthase.	0.814