87 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000028801	BHLH domain-containing protein. (234 aa)
	ENSUAMP00000028186	Uncharacterized protein. (505 aa)
	ENSUAMP00000028019	Uncharacterized protein. (163 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (441 aa)
	ENSUAMP00000027762	Uncharacterized protein. (188 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	PTGIS	Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa)
	CYP20A1	Cytochrome P450 family 20 subfamily A member 1. (470 aa)
	ENSUAMP00000026294	2Fe-2S ferredoxin-type domain-containing protein. (253 aa)
	ENSUAMP00000023045	Uncharacterized protein. (125 aa)
	CYP8B1	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
	FDX1	Ferredoxin 1. (124 aa)
	ENSUAMP00000021070	Uncharacterized protein. (833 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
	ENSUAMP00000019446	Uncharacterized protein. (51 aa)
	ENSUAMP00000019443	Uncharacterized protein. (281 aa)
	CYP2R1	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
	ENSUAMP00000019124	Uncharacterized protein. (241 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	ENSUAMP00000019082	Uncharacterized protein; Belongs to the cytochrome P450 family. (411 aa)
	CYP39A1	Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa)
	ENSUAMP00000018414	Uncharacterized protein; Belongs to the cytochrome P450 family. (404 aa)
	ENSUAMP00000017402	Uncharacterized protein. (494 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (491 aa)
	ENSUAMP00000017348	Uncharacterized protein; Belongs to the cytochrome P450 family. (339 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	TBXAS1	Thromboxane A synthase 1. (441 aa)
	POR	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
	ENSUAMP00000014774	Uncharacterized protein. (214 aa)
	ENSUAMP00000013975	Uncharacterized protein; Belongs to the cytochrome P450 family. (181 aa)
	CYP2J2	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (469 aa)
	ENSUAMP00000013261	Uncharacterized protein. (134 aa)
	CYP46A1	Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (506 aa)
	ENSUAMP00000013046	Uncharacterized protein. (120 aa)
	FADS6	Fatty acid desaturase 6. (340 aa)
	FDXR	NADPH:adrenodoxin oxidoreductase, mitochondrial. (492 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (481 aa)
	CYP2B6	Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (436 aa)
	ENSUAMP00000012528	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	ENSUAMP00000012176	Uncharacterized protein. (507 aa)
	POMC	Proopiomelanocortin. (223 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
	ENSUAMP00000010766	Uncharacterized protein. (93 aa)
	ENSUAMP00000010632	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (485 aa)
	ENSUAMP00000006803	Uncharacterized protein; Belongs to the cytochrome P450 family. (262 aa)
	ENSUAMP00000006303	Uncharacterized protein; Belongs to the cytochrome P450 family. (171 aa)
	ENSUAMP00000005042	Uncharacterized protein. (463 aa)
	RUNX1T1	RUNX1 partner transcriptional co-repressor 1. (603 aa)
	CYP26C1	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
	CYP26A1	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
	ENSUAMP00000002638	Uncharacterized protein. (76 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (465 aa)
	ENSUAMP00000001136	Uncharacterized protein. (80 aa)
	ENSUAMP00000000729	Uncharacterized protein; Belongs to the cytochrome P450 family. (180 aa)
	CYP4F22	Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
	ENSUAMP00000037275	Uncharacterized protein; Belongs to the cytochrome P450 family. (182 aa)
	ENSUAMP00000037273	Uncharacterized protein. (208 aa)
	CYP4F8	Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa)
	ENSUAMP00000037267	Uncharacterized protein. (83 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (482 aa)
	CYP2U1	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (529 aa)
	TTI2	TELO2 interacting protein 2. (477 aa)
	NCOA2	Nuclear receptor coactivator 2. (945 aa)
	CYP2W1	Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (501 aa)
	ENSUAMP00000035193	Uncharacterized protein. (279 aa)
	ENSUAMP00000035192	Uncharacterized protein. (82 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (512 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
	ENSUAMP00000034639	Uncharacterized protein. (463 aa)
	ENSUAMP00000034638	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	CBFA2T2	CBFA2/RUNX1 partner transcriptional co-repressor 2. (575 aa)
	ENSUAMP00000034394	Uncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
	CYP4X1	Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (506 aa)
	CYP4B1	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (493 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (494 aa)
	ENSUAMP00000033863	Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
	CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3. (748 aa)
	CYP51A1	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2. (706 aa)
	ENSUAMP00000032152	Uncharacterized protein. (503 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
	CCDC160	Coiled-coil domain containing 160. (323 aa)
	CYP21A2	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
	ENSUAMP00000028802	Uncharacterized protein. (566 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNT	CYP1A1	ENSUAMP00000012840	ENSUAMP00000035167	Aryl hydrocarbon receptor nuclear translocator.	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	0.646
ARNT	CYP1A2	ENSUAMP00000012840	ENSUAMP00000035169	Aryl hydrocarbon receptor nuclear translocator.	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	0.567
ARNT	CYP1B1	ENSUAMP00000012840	ENSUAMP00000019099	Aryl hydrocarbon receptor nuclear translocator.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.480
ARNT	ENSUAMP00000021070	ENSUAMP00000012840	ENSUAMP00000021070	Aryl hydrocarbon receptor nuclear translocator.	Uncharacterized protein.	0.987
ARNT	ENSUAMP00000028801	ENSUAMP00000012840	ENSUAMP00000028801	Aryl hydrocarbon receptor nuclear translocator.	BHLH domain-containing protein.	0.863
ARNT	ENSUAMP00000028802	ENSUAMP00000012840	ENSUAMP00000028802	Aryl hydrocarbon receptor nuclear translocator.	Uncharacterized protein.	0.810
ARNT	ENSUAMP00000035193	ENSUAMP00000012840	ENSUAMP00000035193	Aryl hydrocarbon receptor nuclear translocator.	Uncharacterized protein.	0.899
ARNT2	ENSUAMP00000021070	ENSUAMP00000032443	ENSUAMP00000021070	Aryl hydrocarbon receptor nuclear translocator 2.	Uncharacterized protein.	0.956
ARNT2	ENSUAMP00000028801	ENSUAMP00000032443	ENSUAMP00000028801	Aryl hydrocarbon receptor nuclear translocator 2.	BHLH domain-containing protein.	0.822
ARNT2	ENSUAMP00000028802	ENSUAMP00000032443	ENSUAMP00000028802	Aryl hydrocarbon receptor nuclear translocator 2.	Uncharacterized protein.	0.911
ARNT2	ENSUAMP00000035193	ENSUAMP00000032443	ENSUAMP00000035193	Aryl hydrocarbon receptor nuclear translocator 2.	Uncharacterized protein.	0.831
CBFA2T2	CBFA2T3	ENSUAMP00000034614	ENSUAMP00000033662	CBFA2/RUNX1 partner transcriptional co-repressor 2.	CBFA2/RUNX1 partner transcriptional co-repressor 3.	0.669
CBFA2T2	RUNX1T1	ENSUAMP00000034614	ENSUAMP00000004554	CBFA2/RUNX1 partner transcriptional co-repressor 2.	RUNX1 partner transcriptional co-repressor 1.	0.594
CBFA2T3	CBFA2T2	ENSUAMP00000033662	ENSUAMP00000034614	CBFA2/RUNX1 partner transcriptional co-repressor 3.	CBFA2/RUNX1 partner transcriptional co-repressor 2.	0.669
CBFA2T3	RUNX1T1	ENSUAMP00000033662	ENSUAMP00000004554	CBFA2/RUNX1 partner transcriptional co-repressor 3.	RUNX1 partner transcriptional co-repressor 1.	0.523
CYP11A1	CYP19A1	ENSUAMP00000031921	ENSUAMP00000002011	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.668
CYP11A1	CYP1A1	ENSUAMP00000031921	ENSUAMP00000035167	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	0.474
CYP11A1	CYP1A2	ENSUAMP00000031921	ENSUAMP00000035169	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	0.478
CYP11A1	CYP1B1	ENSUAMP00000031921	ENSUAMP00000019099	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.432
CYP11A1	CYP20A1	ENSUAMP00000031921	ENSUAMP00000023992	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 20 subfamily A member 1.	0.667