STRINGSTRING
POLR1C POLR1C ENSUAMP00000032400 ENSUAMP00000032400 EP300 EP300 KAT2A KAT2A BAZ2B BAZ2B ENSUAMP00000031302 ENSUAMP00000031302 MYBBP1A MYBBP1A SMARCA5 SMARCA5 DNMT3B DNMT3B ENSUAMP00000029966 ENSUAMP00000029966 H2BE1 H2BE1 MTF2 MTF2 ENSUAMP00000029225 ENSUAMP00000029225 ENSUAMP00000029196 ENSUAMP00000029196 ENSUAMP00000029195 ENSUAMP00000029195 ENSUAMP00000029193 ENSUAMP00000029193 H2BC21 H2BC21 EZH2 EZH2 ZNRD1 ZNRD1 ENSUAMP00000028455 ENSUAMP00000028455 BAZ2A BAZ2A TAF1B TAF1B MYO1A MYO1A POLR2F POLR2F CD3EAP CD3EAP SMARCA1 SMARCA1 JARID2 JARID2 H3-3A H3-3A ENSUAMP00000006335 ENSUAMP00000006335 ENSUAMP00000006470 ENSUAMP00000006470 ENSUAMP00000006561 ENSUAMP00000006561 ENSUAMP00000006688 ENSUAMP00000006688 ENSUAMP00000007225 ENSUAMP00000007225 BAZ1A BAZ1A DNMT1 DNMT1 EZH1 EZH1 ENSUAMP00000024987 ENSUAMP00000024987 SF3B1 SF3B1 MBD2 MBD2 TWISTNB TWISTNB ENSUAMP00000022270 ENSUAMP00000022270 SIRT1 SIRT1 BAZ1B BAZ1B ENSUAMP00000020853 ENSUAMP00000020853 ENSUAMP00000020825 ENSUAMP00000020825 ENSUAMP00000020808 ENSUAMP00000020808 ENSUAMP00000020754 ENSUAMP00000020754 TET3 TET3 ERCC6 ERCC6 ENSUAMP00000018897 ENSUAMP00000018897 UHRF1 UHRF1 H2AX H2AX SUZ12 SUZ12 ENSUAMP00000017773 ENSUAMP00000017773 HIST3H2BB HIST3H2BB ENSUAMP00000017069 ENSUAMP00000017069 H2AZ2 H2AZ2 MYO1C MYO1C POLR1E POLR1E ENSUAMP00000015215 ENSUAMP00000015215 POLR1A POLR1A TAF1A TAF1A DDX50 DDX50 ENSUAMP00000014288 ENSUAMP00000014288 ENSUAMP00000014264 ENSUAMP00000014264 ENSUAMP00000014262 ENSUAMP00000014262 RBBP7 RBBP7 ENSUAMP00000009736 ENSUAMP00000009736 SAP130 SAP130 POLR2E POLR2E MYO1H MYO1H ENSUAMP00000012077 ENSUAMP00000012077 ENSUAMP00000012078 ENSUAMP00000012078 GSK3B GSK3B ENSUAMP00000014260 ENSUAMP00000014260 ENSUAMP00000014243 ENSUAMP00000014243 ENSUAMP00000014224 ENSUAMP00000014224 ENSUAMP00000014212 ENSUAMP00000014212 DNMT3A DNMT3A ENSUAMP00000002618 ENSUAMP00000002618 ENSUAMP00000003497 ENSUAMP00000003497 ENSUAMP00000003527 ENSUAMP00000003527 SAP30BP SAP30BP TBP TBP H3F3B H3F3B H2AZ1 H2AZ1 ENSUAMP00000004341 ENSUAMP00000004341 POLR2H POLR2H KAT2B KAT2B H2BC1 H2BC1 ENSUAMP00000006070 ENSUAMP00000006070 ENSUAMP00000006074 ENSUAMP00000006074 ENSUAMP00000006129 ENSUAMP00000006129 AEBP2 AEBP2 PHF1 PHF1 MYO1B MYO1B TET2 TET2 ENSUAMP00000036515 ENSUAMP00000036515 DEK DEK ENSUAMP00000000140 ENSUAMP00000000140 ENSUAMP00000000300 ENSUAMP00000000300 ENSUAMP00000000805 ENSUAMP00000000805 TBPL2 TBPL2 PHF19 PHF19 MYO1D MYO1D ENSUAMP00000002604 ENSUAMP00000002604 TAF1D TAF1D TDG TDG EED EED ENSUAMP00000006306 ENSUAMP00000006306 ENSUAMP00000006323 ENSUAMP00000006323 ENSUAMP00000033950 ENSUAMP00000033950 ENSUAMP00000033949 ENSUAMP00000033949 ENSUAMP00000033945 ENSUAMP00000033945 ENSUAMP00000033939 ENSUAMP00000033939 ENSUAMP00000033919 ENSUAMP00000033919 ENSUAMP00000033918 ENSUAMP00000033918 ENSUAMP00000033915 ENSUAMP00000033915 H2BC11 H2BC11 RRP8 RRP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLR1CRNA polymerase I and III subunit C. (346 aa)
ENSUAMP00000032400Uncharacterized protein. (67 aa)
EP300E1A binding protein p300. (2399 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
BAZ2BBromodomain adjacent to zinc finger domain 2B. (1934 aa)
ENSUAMP00000031302Histone domain-containing protein; Belongs to the histone H2B family. (170 aa)
MYBBP1AMYB binding protein 1a. (1318 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1047 aa)
DNMT3BDNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (862 aa)
ENSUAMP00000029966annotation not available (113 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
MTF2Metal response element binding transcription factor 2. (597 aa)
ENSUAMP00000029225DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1096 aa)
ENSUAMP00000029196Histone H3; Belongs to the histone H3 family. (136 aa)
ENSUAMP00000029195annotation not available (103 aa)
ENSUAMP00000029193annotation not available (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
ZNRD1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (123 aa)
ENSUAMP00000028455Uncharacterized protein. (71 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1928 aa)
TAF1BTATA-box binding protein associated factor, RNA polymerase I subunit B. (540 aa)
MYO1AMyosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1035 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
CD3EAPCD3e molecule associated protein. (525 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1058 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1160 aa)
H3-3AHistone domain-containing protein. (142 aa)
ENSUAMP00000006335Histone H2B; Belongs to the histone H2B family. (135 aa)
ENSUAMP00000006470GUCT domain-containing protein. (154 aa)
ENSUAMP00000006561Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSUAMP00000006688Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (473 aa)
ENSUAMP00000007225Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1557 aa)
DNMT1DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (981 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
ENSUAMP00000024987PHD-type domain-containing protein. (382 aa)
SF3B1Splicing factor 3b subunit 1. (1122 aa)
MBD2Methyl-CpG binding domain protein 2. (346 aa)
TWISTNBTWIST neighbor. (335 aa)
ENSUAMP00000022270Histone H2B; Belongs to the histone H2B family. (127 aa)
SIRT1Sirtuin 1. (618 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1482 aa)
ENSUAMP00000020853Histone domain-containing protein. (178 aa)
ENSUAMP00000020825annotation not available (103 aa)
ENSUAMP00000020808annotation not available (126 aa)
ENSUAMP00000020754Uncharacterized protein. (105 aa)
TET3Tet_JBP domain-containing protein. (1724 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1482 aa)
ENSUAMP00000018897Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (206 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (812 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (900 aa)
ENSUAMP00000017773CAF1C_H4-bd domain-containing protein. (87 aa)
HIST3H2BBHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSUAMP00000017069Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (134 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
POLR1ERNA polymerase I subunit E. (419 aa)
ENSUAMP00000015215Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
POLR1ARNA polymerase I subunit A. (1248 aa)
TAF1ATATA-box binding protein associated factor, RNA polymerase I subunit A. (450 aa)
DDX50DExD-box helicase 50. (738 aa)
ENSUAMP00000014288Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSUAMP00000014264annotation not available (136 aa)
ENSUAMP00000014262Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (427 aa)
ENSUAMP00000009736Uncharacterized protein. (71 aa)
SAP130Sin3A associated protein 130. (973 aa)
POLR2ERNA polymerase II subunit E. (294 aa)
MYO1HMyosin IH; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1035 aa)
ENSUAMP00000012077RNA_pol_Rpb2_1 domain-containing protein. (169 aa)
ENSUAMP00000012078annotation not available (80 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
ENSUAMP00000014260annotation not available (103 aa)
ENSUAMP00000014243Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSUAMP00000014224annotation not available (103 aa)
ENSUAMP00000014212annotation not available (126 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
ENSUAMP00000002618Histone H2A; Belongs to the histone H2A family. (113 aa)
ENSUAMP00000003497Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSUAMP00000003527Uncharacterized protein. (72 aa)
SAP30BPSAP30 binding protein. (301 aa)
TBPTATA-box binding protein. (324 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (159 aa)
ENSUAMP00000004341annotation not available (103 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
KAT2BLysine acetyltransferase 2B. (629 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSUAMP00000006070Uncharacterized protein. (206 aa)
ENSUAMP00000006074Uncharacterized protein. (271 aa)
ENSUAMP00000006129Histone domain-containing protein. (199 aa)
AEBP2AE binding protein 2. (274 aa)
PHF1PHD finger protein 1. (567 aa)
MYO1BMyosin IB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (980 aa)
TET2Tet methylcytosine dioxygenase 2. (2021 aa)
ENSUAMP00000036515Uncharacterized protein. (78 aa)
DEKDEK proto-oncogene. (351 aa)
ENSUAMP00000000140RNA_pol_Rpb1_1 domain-containing protein. (281 aa)
ENSUAMP00000000300Bromo domain-containing protein. (84 aa)
ENSUAMP00000000805Uncharacterized protein. (80 aa)
TBPL2TATA-box binding protein like 2. (344 aa)
PHF19PHD finger protein 19. (580 aa)
MYO1DMyosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
ENSUAMP00000002604CAF1C_H4-bd domain-containing protein. (133 aa)
TAF1DTATA-box binding protein associated factor, RNA polymerase I subunit D. (275 aa)
TDGThymine DNA glycosylase. (407 aa)
EEDEmbryonic ectoderm development. (441 aa)
ENSUAMP00000006306annotation not available (103 aa)
ENSUAMP00000006323Histone H3; Belongs to the histone H3 family. (136 aa)
ENSUAMP00000033950annotation not available (103 aa)
ENSUAMP00000033949annotation not available (126 aa)
ENSUAMP00000033945Histone H3; Belongs to the histone H3 family. (93 aa)
ENSUAMP00000033939Histone H2B; Belongs to the histone H2B family. (132 aa)
ENSUAMP00000033919Histone domain-containing protein; Belongs to the histone H2B family. (128 aa)
ENSUAMP00000033918annotation not available (103 aa)
ENSUAMP00000033915Histone domain-containing protein. (125 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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