65 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000025995	Uncharacterized protein. (52 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (793 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	IRX4	Iroquois homeobox 4. (520 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	SNW1	SNW domain containing 1. (511 aa)
	ENSUAMP00000029127	Homeobox domain-containing protein. (217 aa)
	USP9X	Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2153 aa)
	CDK9	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
	IRX6	Iroquois homeobox 6. (493 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	NEDD4L	E3 ubiquitin-protein ligase. (866 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	CCNC	Cyclin C. (198 aa)
	IRX2	Iroquois homeobox 2. (330 aa)
	ENSUAMP00000034195	Uncharacterized protein. (1577 aa)
	CDK19	Cyclin dependent kinase 19. (460 aa)
	UBE2D1	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	CCNT1	Cyclin T1; Belongs to the cyclin family. (726 aa)
	ENSUAMP00000036702	Protein kinase domain-containing protein. (154 aa)
	ENSUAMP00000036703	Protein kinase domain-containing protein. (185 aa)
	ENSUAMP00000036704	Uncharacterized protein. (132 aa)
	CCNQ	Cyclin Q; Belongs to the cyclin family. (250 aa)
	MEIS3	Meis homeobox 3. (315 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	ENSUAMP00000025215	BZIP domain-containing protein. (347 aa)
	ENSUAMP00000025192	Ubiquitin-like domain-containing protein. (156 aa)
	ENSUAMP00000025159	BZIP domain-containing protein. (314 aa)
	E2F5	E2F transcription factor 5. (350 aa)
	TFDP2	Transcription factor. (360 aa)
	SKI	SKI proto-oncogene. (704 aa)
	IRX1	Iroquois homeobox 1. (447 aa)
	CCNK	Cyclin K; Belongs to the cyclin family. (353 aa)
	ENSUAMP00000021443	Ubiquitin-like domain-containing protein. (77 aa)
	ENSUAMP00000020715	Ubiquitin-like domain-containing protein. (132 aa)
	RBL1	RB transcriptional corepressor like 1. (1068 aa)
	KXD1	KxDL motif containing 1. (128 aa)
	E2F4	E2F transcription factor 4. (406 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	MKX	Mohawk homeobox. (345 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (975 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
	WWTR1	WW domain containing transcription regulator 1. (400 aa)
	ENSUAMP00000017561	Uncharacterized protein. (285 aa)
	SMURF2	E3 ubiquitin-protein ligase. (736 aa)
	TGIF2	TGFB induced factor homeobox 2. (237 aa)
	IRX5	Iroquois homeobox 5. (483 aa)
	IRX3	Iroquois homeobox 3. (502 aa)
	MEN1	Menin 1. (610 aa)
	SP1	Sp1 transcription factor. (780 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
	ENSUAMP00000010405	Uncharacterized protein. (120 aa)
	ENSUAMP00000010402	BBC domain-containing protein. (492 aa)
	ENSUAMP00000010232	Ubiquitin-like domain-containing protein. (88 aa)
	RNF111	Ring finger protein 111. (985 aa)
	TFDP1	Transcription factor Dp-1. (477 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
	ENSUAMP00000004097	Uncharacterized protein. (245 aa)
	ENSUAMP00000002926	Homeobox domain-containing protein. (89 aa)
	ENSUAMP00000002663	Homeobox domain-containing protein. (252 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (733 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1B4	SMAD7	ENSUAMP00000004973	ENSUAMP00000027174	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Mothers against decapentaplegic homolog.	0.400
ATP1B4	SNW1	ENSUAMP00000004973	ENSUAMP00000029110	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	SNW domain containing 1.	0.920
CCNC	CCNK	ENSUAMP00000031929	ENSUAMP00000021694	Cyclin C.	Cyclin K; Belongs to the cyclin family.	0.736
CCNC	CCNQ	ENSUAMP00000031929	ENSUAMP00000036930	Cyclin C.	Cyclin Q; Belongs to the cyclin family.	0.531
CCNC	CCNT1	ENSUAMP00000031929	ENSUAMP00000035720	Cyclin C.	Cyclin T1; Belongs to the cyclin family.	0.657
CCNC	CCNT2	ENSUAMP00000031929	ENSUAMP00000000217	Cyclin C.	Cyclin T2; Belongs to the cyclin family.	0.647
CCNC	CDK19	ENSUAMP00000031929	ENSUAMP00000035009	Cyclin C.	Cyclin dependent kinase 19.	0.992
CCNC	CDK9	ENSUAMP00000031929	ENSUAMP00000029754	Cyclin C.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.736
CCNC	ENSUAMP00000036702	ENSUAMP00000031929	ENSUAMP00000036702	Cyclin C.	Protein kinase domain-containing protein.	0.992
CCNC	ENSUAMP00000036703	ENSUAMP00000031929	ENSUAMP00000036703	Cyclin C.	Protein kinase domain-containing protein.	0.992
CCNC	ENSUAMP00000036704	ENSUAMP00000031929	ENSUAMP00000036704	Cyclin C.	Uncharacterized protein.	0.992
CCNC	SMAD4	ENSUAMP00000031929	ENSUAMP00000018392	Cyclin C.	Mothers against decapentaplegic homolog.	0.519
CCNK	CCNC	ENSUAMP00000021694	ENSUAMP00000031929	Cyclin K; Belongs to the cyclin family.	Cyclin C.	0.736
CCNK	CCNT1	ENSUAMP00000021694	ENSUAMP00000035720	Cyclin K; Belongs to the cyclin family.	Cyclin T1; Belongs to the cyclin family.	0.638
CCNK	CCNT2	ENSUAMP00000021694	ENSUAMP00000000217	Cyclin K; Belongs to the cyclin family.	Cyclin T2; Belongs to the cyclin family.	0.720
CCNK	CDK19	ENSUAMP00000021694	ENSUAMP00000035009	Cyclin K; Belongs to the cyclin family.	Cyclin dependent kinase 19.	0.569
CCNK	CDK9	ENSUAMP00000021694	ENSUAMP00000029754	Cyclin K; Belongs to the cyclin family.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.972
CCNK	ENSUAMP00000036702	ENSUAMP00000021694	ENSUAMP00000036702	Cyclin K; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.569
CCNK	ENSUAMP00000036703	ENSUAMP00000021694	ENSUAMP00000036703	Cyclin K; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.569
CCNK	ENSUAMP00000036704	ENSUAMP00000021694	ENSUAMP00000036704	Cyclin K; Belongs to the cyclin family.	Uncharacterized protein.	0.569