34 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000000300	Bromo domain-containing protein. (84 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (446 aa)
	ENSUAMP00000003260	Uncharacterized protein. (261 aa)
	ENSUAMP00000003509	LAG1_DNAbind domain-containing protein. (58 aa)
	ENSUAMP00000003560	Uncharacterized protein. (416 aa)
	KAT2B	Lysine acetyltransferase 2B. (629 aa)
	ENSUAMP00000007257	Hist_deacetyl domain-containing protein. (252 aa)
	HDAC11	Histone deacetylase 11. (347 aa)
	ENSUAMP00000011802	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1116 aa)
	HDAC6	Histone deacetylase 6. (1136 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (815 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (933 aa)
	HDAC10	Histone deacetylase 10. (668 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (520 aa)
	ENSUAMP00000019969	Uncharacterized protein. (753 aa)
	NOTCH4	Notch receptor 4. (1894 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (408 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (537 aa)
	HDAC9	Histone deacetylase 9. (587 aa)
	ENSUAMP00000023751	Uncharacterized protein. (407 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	SNW1	SNW domain containing 1. (511 aa)
	ENSUAMP00000029419	Uncharacterized protein. (616 aa)
	CREBBP	CREB binding protein. (2333 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	ENSUAMP00000034574	Uncharacterized protein. (525 aa)
	ENSUAMP00000034736	HDAC4_Gln domain-containing protein. (230 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (963 aa)
	ENSUAMP00000036445	MamL-1 domain-containing protein. (178 aa)
	ENSUAMP00000036902	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (388 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	ENSUAMP00000000300	ENSUAMP00000030777	ENSUAMP00000000300	CREB binding protein.	Bromo domain-containing protein.	0.948
CREBBP	ENSUAMP00000003509	ENSUAMP00000030777	ENSUAMP00000003509	CREB binding protein.	LAG1_DNAbind domain-containing protein.	0.892
CREBBP	ENSUAMP00000003560	ENSUAMP00000030777	ENSUAMP00000003560	CREB binding protein.	Uncharacterized protein.	0.952
CREBBP	ENSUAMP00000007257	ENSUAMP00000030777	ENSUAMP00000007257	CREB binding protein.	Hist_deacetyl domain-containing protein.	0.419
CREBBP	ENSUAMP00000011802	ENSUAMP00000030777	ENSUAMP00000011802	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.419
CREBBP	ENSUAMP00000019969	ENSUAMP00000030777	ENSUAMP00000019969	CREB binding protein.	Uncharacterized protein.	0.570
CREBBP	ENSUAMP00000025261	ENSUAMP00000030777	ENSUAMP00000025261	CREB binding protein.	GPS2_interact domain-containing protein.	0.720
CREBBP	ENSUAMP00000029419	ENSUAMP00000030777	ENSUAMP00000029419	CREB binding protein.	Uncharacterized protein.	0.931
CREBBP	ENSUAMP00000034574	ENSUAMP00000030777	ENSUAMP00000034574	CREB binding protein.	Uncharacterized protein.	0.490
CREBBP	ENSUAMP00000034736	ENSUAMP00000030777	ENSUAMP00000034736	CREB binding protein.	HDAC4_Gln domain-containing protein.	0.461
CREBBP	ENSUAMP00000036445	ENSUAMP00000030777	ENSUAMP00000036445	CREB binding protein.	MamL-1 domain-containing protein.	0.734
CREBBP	ENSUAMP00000036902	ENSUAMP00000030777	ENSUAMP00000036902	CREB binding protein.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.616
CREBBP	HDAC1	ENSUAMP00000030777	ENSUAMP00000017970	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.653
CREBBP	HDAC10	ENSUAMP00000030777	ENSUAMP00000016901	CREB binding protein.	Histone deacetylase 10.	0.419
CREBBP	HDAC11	ENSUAMP00000030777	ENSUAMP00000010585	CREB binding protein.	Histone deacetylase 11.	0.464
CREBBP	HDAC2	ENSUAMP00000030777	ENSUAMP00000001578	CREB binding protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.653
CREBBP	HDAC3	ENSUAMP00000030777	ENSUAMP00000037450	CREB binding protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.732
CREBBP	HDAC4	ENSUAMP00000030777	ENSUAMP00000013619	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.461
CREBBP	HDAC6	ENSUAMP00000030777	ENSUAMP00000013238	CREB binding protein.	Histone deacetylase 6.	0.520
CREBBP	HDAC7	ENSUAMP00000030777	ENSUAMP00000035596	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.508