STRINGSTRING
BCLAF1 BCLAF1 ENSUAMP00000006902 ENSUAMP00000006902 ENSUAMP00000006908 ENSUAMP00000006908 MED8 MED8 MED21 MED21 PPARG PPARG MAP7D3 MAP7D3 HDAC3 HDAC3 MED13L MED13L MED18 MED18 ENSUAMP00000031615 ENSUAMP00000031615 MAP7D1 MAP7D1 NCOR2 NCOR2 KLF5 KLF5 ENSUAMP00000029904 ENSUAMP00000029904 PLIN1 PLIN1 ENSUAMP00000028917 ENSUAMP00000028917 PPARGC1A PPARGC1A RXRA RXRA EBF2 EBF2 ENSUAMP00000025494 ENSUAMP00000025494 ENSUAMP00000025261 ENSUAMP00000025261 NCOR1 NCOR1 ZNF638 ZNF638 THRAP3 THRAP3 MED22 MED22 ADIRF ADIRF MED19 MED19 CEBPD CEBPD ENSUAMP00000012773 ENSUAMP00000012773 MED29 MED29 ENSUAMP00000012019 ENSUAMP00000012019 MAP7 MAP7 EBF3 EBF3 MED11 MED11 MED9 MED9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCLAF1BCL2 associated transcription factor 1. (968 aa)
ENSUAMP00000006902COE1_DBD domain-containing protein. (182 aa)
ENSUAMP00000006908Uncharacterized protein. (122 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (268 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
MAP7D3MAP7 domain containing 3. (891 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
MED13LMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2064 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
ENSUAMP00000031615Uncharacterized protein. (157 aa)
MAP7D1MAP7 domain containing 1. (788 aa)
NCOR2Nuclear receptor corepressor 2. (2465 aa)
KLF5Kruppel like factor 5. (442 aa)
ENSUAMP00000029904Uncharacterized protein. (323 aa)
PLIN1Perilipin; Belongs to the perilipin family. (507 aa)
ENSUAMP00000028917Uncharacterized protein. (909 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
RXRARetinoid X receptor alpha. (469 aa)
EBF2EBF transcription factor 2. (582 aa)
ENSUAMP00000025494COE1_DBD domain-containing protein. (157 aa)
ENSUAMP00000025261GPS2_interact domain-containing protein. (204 aa)
NCOR1Nuclear receptor corepressor 1. (2267 aa)
ZNF638Zinc finger protein 638. (1964 aa)
THRAP3Thyroid hormone receptor associated protein 3. (958 aa)
MED22Mediator complex subunit 22. (200 aa)
ADIRFAdipogenesis regulatory factor. (68 aa)
MED19Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (251 aa)
CEBPDCCAAT/enhancer-binding protein. (273 aa)
ENSUAMP00000012773TFIIS N-terminal domain-containing protein. (599 aa)
MED29Mediator complex subunit 29. (200 aa)
ENSUAMP00000012019Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (104 aa)
MAP7Microtubule associated protein 7. (679 aa)
EBF3EBF transcription factor 3. (596 aa)
MED11Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (117 aa)
MED9Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (147 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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