62 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR2C2AP	Nuclear receptor 2C2 associated protein. (139 aa)
	PGR	Progesterone receptor. (634 aa)
	CEP55	Centrosomal protein 55. (463 aa)
	NR2C2	Nuclear receptor subfamily 2 group C member 2. (629 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	ENSUAMP00000004542	Uncharacterized protein. (171 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	CCDC134	Coiled-coil domain containing 134. (229 aa)
	NRBP1	Nuclear receptor binding protein 1. (535 aa)
	NR2E3	Nuclear receptor subfamily 2 group E member 3. (411 aa)
	ENSUAMP00000010069	Uncharacterized protein. (357 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (503 aa)
	NR1I2	Nuclear receptor subfamily 1 group I member 2. (379 aa)
	ENSUAMP00000012231	Uncharacterized protein. (632 aa)
	AR	Androgen receptor. (905 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	NR2F6	Nuclear receptor subfamily 2 group F member 6. (388 aa)
	RORB	RAR related orphan receptor B. (502 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	ENSUAMP00000016402	Uncharacterized protein. (427 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (619 aa)
	ENSUAMP00000017524	Uncharacterized protein. (542 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (455 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	ESRRA	Estrogen related receptor alpha. (422 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (600 aa)
	THRA	Thyroid hormone receptor alpha. (511 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (546 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	RORC	RAR related orphan receptor C. (517 aa)
	ESRRG	Estrogen related receptor gamma. (435 aa)
	ESRRB	Estrogen related receptor beta. (454 aa)
	RORA	RAR related orphan receptor A. (522 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	HNF4G	Hepatocyte nuclear factor 4 gamma. (408 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	THRB	Thyroid hormone receptor beta. (467 aa)
	ENSUAMP00000027844	Nuc_recep-AF1 domain-containing protein. (202 aa)
	ENSUAMP00000027845	Uncharacterized protein. (347 aa)
	ENSUAMP00000028186	Uncharacterized protein. (505 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (781 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	NR2C1	Nuclear receptor subfamily 2 group C member 1. (631 aa)
	NR6A1	Nuclear receptor subfamily 6 group A member 1. (454 aa)
	NR2F2	Nuclear receptor subfamily 2 group F member 2. (414 aa)
	NR1I3	Nuclear receptor subfamily 1 group I member 3. (356 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	NR2F1	Nuclear receptor subfamily 2 group F member 1. (263 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	NR0B2	Nuclear receptor subfamily 0 group B member 2. (301 aa)
	VDR	Vitamin D receptor. (427 aa)
	NRBF2	Nuclear receptor binding factor 2. (244 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	C1orf56	Chromosome 1 open reading frame 56. (358 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (482 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ENSUAMP00000012231	ENSUAMP00000013075	ENSUAMP00000012231	Androgen receptor.	Uncharacterized protein.	0.586
AR	ENSUAMP00000016402	ENSUAMP00000013075	ENSUAMP00000016402	Androgen receptor.	Uncharacterized protein.	0.544
AR	ENSUAMP00000025261	ENSUAMP00000013075	ENSUAMP00000025261	Androgen receptor.	GPS2_interact domain-containing protein.	0.836
AR	ESR1	ENSUAMP00000013075	ENSUAMP00000006270	Androgen receptor.	Estrogen receptor 1.	0.587
AR	MED1	ENSUAMP00000013075	ENSUAMP00000034047	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.613
AR	NCOR1	ENSUAMP00000013075	ENSUAMP00000025256	Androgen receptor.	Nuclear receptor corepressor 1.	0.836
AR	NCOR2	ENSUAMP00000013075	ENSUAMP00000030789	Androgen receptor.	Nuclear receptor corepressor 2.	0.885
AR	NR3C1	ENSUAMP00000013075	ENSUAMP00000029768	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.582
AR	PGR	ENSUAMP00000013075	ENSUAMP00000000820	Androgen receptor.	Progesterone receptor.	0.618
ENSUAMP00000004542	ENSUAMP00000025261	ENSUAMP00000004542	ENSUAMP00000025261	Uncharacterized protein.	GPS2_interact domain-containing protein.	0.477
ENSUAMP00000004542	ENSUAMP00000027844	ENSUAMP00000004542	ENSUAMP00000027844	Uncharacterized protein.	Nuc_recep-AF1 domain-containing protein.	0.486
ENSUAMP00000004542	ENSUAMP00000027845	ENSUAMP00000004542	ENSUAMP00000027845	Uncharacterized protein.	Uncharacterized protein.	0.533
ENSUAMP00000004542	MED1	ENSUAMP00000004542	ENSUAMP00000034047	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.502
ENSUAMP00000004542	NCOR1	ENSUAMP00000004542	ENSUAMP00000025256	Uncharacterized protein.	Nuclear receptor corepressor 1.	0.477
ENSUAMP00000004542	NCOR2	ENSUAMP00000004542	ENSUAMP00000030789	Uncharacterized protein.	Nuclear receptor corepressor 2.	0.581
ENSUAMP00000004542	NR4A2	ENSUAMP00000004542	ENSUAMP00000015464	Uncharacterized protein.	Nuclear receptor subfamily 4 group A member 2.	0.419
ENSUAMP00000004542	NR4A3	ENSUAMP00000004542	ENSUAMP00000016872	Uncharacterized protein.	Nuclear receptor subfamily 4 group A member 3.	0.593
ENSUAMP00000004542	RXRA	ENSUAMP00000004542	ENSUAMP00000026794	Uncharacterized protein.	Retinoid X receptor alpha.	0.907
ENSUAMP00000004542	RXRB	ENSUAMP00000004542	ENSUAMP00000035462	Uncharacterized protein.	Retinoid X receptor beta.	0.461
ENSUAMP00000010069	ENSUAMP00000025261	ENSUAMP00000010069	ENSUAMP00000025261	Uncharacterized protein.	GPS2_interact domain-containing protein.	0.477