STRINGSTRING
VRK3 VRK3 MAPKAPK2 MAPKAPK2 NOD1 NOD1 ENSUAMP00000001970 ENSUAMP00000001970 ENSUAMP00000001976 ENSUAMP00000001976 ENSUAMP00000001995 ENSUAMP00000001995 TAB2 TAB2 PPP4R1 PPP4R1 TAB1 TAB1 UBE2V1 UBE2V1 FNBP4 FNBP4 ENSUAMP00000006374 ENSUAMP00000006374 ENSUAMP00000007290 ENSUAMP00000007290 ENSUAMP00000007291 ENSUAMP00000007291 JUN JUN MAPK8 MAPK8 ENSUAMP00000009614 ENSUAMP00000009614 ATF2 ATF2 ENSUAMP00000010232 ENSUAMP00000010232 ENSUAMP00000011014 ENSUAMP00000011014 RPS6KA2 RPS6KA2 PPP2R1A PPP2R1A MAPK1 MAPK1 IKBKG IKBKG RPS6KA1 RPS6KA1 ENSUAMP00000015662 ENSUAMP00000015662 MAPK15 MAPK15 ATF1 ATF1 DUSP4 DUSP4 ENSUAMP00000016793 ENSUAMP00000016793 MAPK11 MAPK11 DUSP6 DUSP6 MAPKAPK3 MAPKAPK3 RPS6KA5 RPS6KA5 IL17RB IL17RB PPP4R4 PPP4R4 MAP2K3 MAP2K3 KXD1 KXD1 ENSUAMP00000020715 ENSUAMP00000020715 ENSUAMP00000021443 ENSUAMP00000021443 PPP2R5D PPP2R5D MAPK10 MAPK10 ENSUAMP00000022960 ENSUAMP00000022960 ENSUAMP00000023088 ENSUAMP00000023088 PPP2CA PPP2CA RIPK2 RIPK2 CREB1 CREB1 ENSUAMP00000024093 ENSUAMP00000024093 IL17A IL17A IL17F IL17F IRAK1 IRAK1 ENSUAMP00000025192 ENSUAMP00000025192 RELCH RELCH IL17C IL17C CREB5 CREB5 MAP2K6 MAP2K6 DUSP7 DUSP7 TMEM189-UBE2V1 TMEM189-UBE2V1 TAB3 TAB3 PPP2CB PPP2CB ELK1 ELK1 MAP2K7 MAP2K7 MAPK9 MAPK9 TRAF6 TRAF6 RPS6KA4 RPS6KA4 RPS6KA3 RPS6KA3 ENSUAMP00000031438 ENSUAMP00000031438 MAPK3 MAPK3 IL25 IL25 MAP3K7 MAP3K7 MAPK14 MAPK14 IRAK2 IRAK2 ENSUAMP00000032533 ENSUAMP00000032533 ENSUAMP00000032535 ENSUAMP00000032535 MAP2K4 MAP2K4 ENSUAMP00000033331 ENSUAMP00000033331 FOSL2 FOSL2 ENSUAMP00000034960 ENSUAMP00000034960 ENSUAMP00000036314 ENSUAMP00000036314
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VRK3VRK serine/threonine kinase 3. (483 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (387 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (874 aa)
ENSUAMP00000001970Uncharacterized protein. (152 aa)
ENSUAMP00000001976IL17_R_N domain-containing protein. (147 aa)
ENSUAMP00000001995IL17_R_N domain-containing protein. (421 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (683 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (937 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (156 aa)
FNBP4Formin binding protein 4. (1018 aa)
ENSUAMP00000006374Uncharacterized protein. (178 aa)
ENSUAMP00000007290Uncharacterized protein. (172 aa)
ENSUAMP00000007291SEFIR domain-containing protein. (585 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000009614WRNPLPNID domain-containing protein. (950 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSUAMP00000010232Ubiquitin-like domain-containing protein. (88 aa)
ENSUAMP00000011014Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (474 aa)
RPS6KA2Ribosomal protein S6 kinase. (753 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
RPS6KA1Ribosomal protein S6 kinase. (836 aa)
ENSUAMP00000015662UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
MAPK15Mitogen-activated protein kinase. (680 aa)
ATF1Activating transcription factor 1. (270 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
IL17RBInterleukin 17 receptor B. (489 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (751 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
KXD1KxDL motif containing 1. (128 aa)
ENSUAMP00000020715Ubiquitin-like domain-containing protein. (132 aa)
ENSUAMP00000021443Ubiquitin-like domain-containing protein. (77 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (601 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
ENSUAMP00000022960Uncharacterized protein. (70 aa)
ENSUAMP00000023088Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (208 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSUAMP00000024093G protein gamma domain-containing protein. (201 aa)
IL17AInterleukin 17A. (161 aa)
IL17FInterleukin 17F. (156 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (664 aa)
ENSUAMP00000025192Ubiquitin-like domain-containing protein. (156 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (777 aa)
IL17CInterleukin 17C. (201 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
TMEM189-UBE2V1TMEM189-UBE2V1 readthrough. (247 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ELK1ETS transcription factor ELK1. (435 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
RPS6KA3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
ENSUAMP00000031438Protein kinase domain-containing protein. (456 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
IL25Interleukin 25. (169 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
ENSUAMP00000032533Uncharacterized protein. (127 aa)
ENSUAMP00000032535Uncharacterized protein. (145 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
ENSUAMP00000033331UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
ENSUAMP00000036314Protein kinase domain-containing protein. (321 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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