20 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RELB	RELB proto-oncogene, NF-kB subunit. (575 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (508 aa)
	ENSUAMP00000026993	Uncharacterized protein. (118 aa)
	ENSUAMP00000036324	Uncharacterized protein. (189 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	SRMS	Tyrosine-protein kinase. (492 aa)
	PTK6	Tyrosine-protein kinase. (482 aa)
	EP300	E1A binding protein p300. (2399 aa)
	ENSUAMP00000030787	Uncharacterized protein. (84 aa)
	CREBBP	CREB binding protein. (2333 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
	ENSUAMP00000027770	C-type lectin domain-containing protein. (246 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (972 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (798 aa)
	ENSUAMP00000015993	Uncharacterized protein. (98 aa)
	PAK3	P21 (RAC1) activated kinase 3. (547 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	EP300	ENSUAMP00000030777	ENSUAMP00000031856	CREB binding protein.	E1A binding protein p300.	0.997
CREBBP	NFKB1	ENSUAMP00000030777	ENSUAMP00000021424	CREB binding protein.	Nuclear factor kappa B subunit 1.	0.756
CREBBP	PRKACB	ENSUAMP00000030777	ENSUAMP00000033341	CREB binding protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.967
CREBBP	RELA	ENSUAMP00000030777	ENSUAMP00000026886	CREB binding protein.	RELA proto-oncogene, NF-kB subunit.	0.983
CREBBP	RELB	ENSUAMP00000030777	ENSUAMP00000030557	CREB binding protein.	RELB proto-oncogene, NF-kB subunit.	0.745
ENSUAMP00000015993	ENSUAMP00000030787	ENSUAMP00000015993	ENSUAMP00000030787	Uncharacterized protein.	Uncharacterized protein.	0.864
ENSUAMP00000015993	KRAS	ENSUAMP00000015993	ENSUAMP00000020812	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.846
ENSUAMP00000015993	RAF1	ENSUAMP00000015993	ENSUAMP00000030761	Uncharacterized protein.	Raf-1 proto-oncogene, serine/threonine kinase.	0.864
ENSUAMP00000026993	ENSUAMP00000030787	ENSUAMP00000026993	ENSUAMP00000030787	Uncharacterized protein.	Uncharacterized protein.	0.864
ENSUAMP00000026993	KRAS	ENSUAMP00000026993	ENSUAMP00000020812	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.847
ENSUAMP00000026993	RAF1	ENSUAMP00000026993	ENSUAMP00000030761	Uncharacterized protein.	Raf-1 proto-oncogene, serine/threonine kinase.	0.864
ENSUAMP00000030787	ENSUAMP00000015993	ENSUAMP00000030787	ENSUAMP00000015993	Uncharacterized protein.	Uncharacterized protein.	0.864
ENSUAMP00000030787	ENSUAMP00000026993	ENSUAMP00000030787	ENSUAMP00000026993	Uncharacterized protein.	Uncharacterized protein.	0.864
ENSUAMP00000030787	ENSUAMP00000036324	ENSUAMP00000030787	ENSUAMP00000036324	Uncharacterized protein.	Uncharacterized protein.	0.864
ENSUAMP00000030787	KRAS	ENSUAMP00000030787	ENSUAMP00000020812	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.948
ENSUAMP00000030787	NFKB1	ENSUAMP00000030787	ENSUAMP00000021424	Uncharacterized protein.	Nuclear factor kappa B subunit 1.	0.883
ENSUAMP00000030787	PAK1	ENSUAMP00000030787	ENSUAMP00000007053	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.885
ENSUAMP00000030787	PAK2	ENSUAMP00000030787	ENSUAMP00000024282	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.884
ENSUAMP00000030787	PAK3	ENSUAMP00000030787	ENSUAMP00000010723	Uncharacterized protein.	P21 (RAC1) activated kinase 3.	0.881
ENSUAMP00000030787	PRKACB	ENSUAMP00000030787	ENSUAMP00000033341	Uncharacterized protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.884