(20 nodes) Translesion synthesis by POLK network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000025192	Ubiquitin-like domain-containing protein. (156 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa)
	ENSUAMP00000022046	RFC1 domain-containing protein. (138 aa)
	RFC3	Replication factor C subunit 3. (185 aa)
	ENSUAMP00000028972	Uncharacterized protein. (262 aa)
	ENSUAMP00000031071	Replication factor C subunit 1. (1147 aa)
	ENSUAMP00000031944	Uncharacterized protein. (79 aa)
	RFC2	Replication factor C subunit 2. (368 aa)
	RFC5	Replication factor C subunit 5. (255 aa)
	ENSUAMP00000021443	Ubiquitin-like domain-containing protein. (77 aa)
	KXD1	KxDL motif containing 1. (128 aa)
	ENSUAMP00000020715	Ubiquitin-like domain-containing protein. (132 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (2648 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	ENSUAMP00000010232	Ubiquitin-like domain-containing protein. (88 aa)
	POLK	DNA polymerase kappa. (542 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000010232	ENSUAMP00000021443	ENSUAMP00000010232	ENSUAMP00000021443	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.998
ENSUAMP00000010232	ENSUAMP00000025192	ENSUAMP00000010232	ENSUAMP00000025192	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.999
ENSUAMP00000010232	PCNA	ENSUAMP00000010232	ENSUAMP00000015332	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.897
ENSUAMP00000010232	POLK	ENSUAMP00000010232	ENSUAMP00000010207	Ubiquitin-like domain-containing protein.	DNA polymerase kappa.	0.589
ENSUAMP00000010232	REV3L	ENSUAMP00000010232	ENSUAMP00000020789	Ubiquitin-like domain-containing protein.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.553
ENSUAMP00000020715	ENSUAMP00000021443	ENSUAMP00000020715	ENSUAMP00000021443	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.959
ENSUAMP00000020715	ENSUAMP00000025192	ENSUAMP00000020715	ENSUAMP00000025192	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.991
ENSUAMP00000020715	PCNA	ENSUAMP00000020715	ENSUAMP00000015332	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.897
ENSUAMP00000020715	POLK	ENSUAMP00000020715	ENSUAMP00000010207	Ubiquitin-like domain-containing protein.	DNA polymerase kappa.	0.589
ENSUAMP00000020715	REV3L	ENSUAMP00000020715	ENSUAMP00000020789	Ubiquitin-like domain-containing protein.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.553
ENSUAMP00000021443	ENSUAMP00000010232	ENSUAMP00000021443	ENSUAMP00000010232	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.998
ENSUAMP00000021443	ENSUAMP00000020715	ENSUAMP00000021443	ENSUAMP00000020715	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.959
ENSUAMP00000021443	ENSUAMP00000022046	ENSUAMP00000021443	ENSUAMP00000022046	Ubiquitin-like domain-containing protein.	RFC1 domain-containing protein.	0.580
ENSUAMP00000021443	ENSUAMP00000025192	ENSUAMP00000021443	ENSUAMP00000025192	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.998
ENSUAMP00000021443	ENSUAMP00000028972	ENSUAMP00000021443	ENSUAMP00000028972	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.538
ENSUAMP00000021443	ENSUAMP00000031071	ENSUAMP00000021443	ENSUAMP00000031071	Ubiquitin-like domain-containing protein.	Replication factor C subunit 1.	0.580
ENSUAMP00000021443	ENSUAMP00000031944	ENSUAMP00000021443	ENSUAMP00000031944	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.538
ENSUAMP00000021443	KXD1	ENSUAMP00000021443	ENSUAMP00000020501	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.701
ENSUAMP00000021443	MAD2L2	ENSUAMP00000021443	ENSUAMP00000024529	Ubiquitin-like domain-containing protein.	Mitotic arrest deficient 2 like 2.	0.573
ENSUAMP00000021443	PCNA	ENSUAMP00000021443	ENSUAMP00000015332	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.940