(19 nodes) Regulation of TP53 Activity through Association with Co-factors network (Ursus americanus)

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Your Input:
	ENSUAMP00000007117	Uncharacterized protein. (55 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ZNF385C	Zinc finger protein 385C. (422 aa)
	C17orf113	Chromosome 17 open reading frame 113. (639 aa)
	POU4F2	POU domain protein. (408 aa)
	ZNF385A	Zinc finger protein 385A. (386 aa)
	PPP1R13L	Protein phosphatase 1 regulatory subunit 13 like. (799 aa)
	PHF20	PHD finger protein 20. (1001 aa)
	ENSUAMP00000015102	Uncharacterized protein. (121 aa)
	ENSUAMP00000015093	Uncharacterized protein. (1064 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
	POU4F3	POU domain protein. (338 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	AKT1	Non-specific serine/threonine protein kinase. (572 aa)
	TP53BP2	Tumor protein p53 binding protein 2. (1157 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ENSUAMP00000007110	BEN domain-containing protein. (382 aa)
	ENSUAMP00000003796	C2H2-type domain-containing protein. (240 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSUAMP00000010674	ENSUAMP00000037592	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT1	AKT3	ENSUAMP00000010674	ENSUAMP00000011671	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT1	PHF20	ENSUAMP00000010674	ENSUAMP00000016930	Non-specific serine/threonine protein kinase.	PHD finger protein 20.	0.506
AKT1	TP53	ENSUAMP00000010674	ENSUAMP00000000913	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.924
AKT2	AKT1	ENSUAMP00000037592	ENSUAMP00000010674	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.875
AKT2	AKT3	ENSUAMP00000037592	ENSUAMP00000011671	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT2	PHF20	ENSUAMP00000037592	ENSUAMP00000016930	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PHD finger protein 20.	0.506
AKT2	TP53	ENSUAMP00000037592	ENSUAMP00000000913	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.924
AKT3	AKT1	ENSUAMP00000011671	ENSUAMP00000010674	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.875
AKT3	AKT2	ENSUAMP00000011671	ENSUAMP00000037592	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT3	PHF20	ENSUAMP00000011671	ENSUAMP00000016930	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PHD finger protein 20.	0.506
AKT3	TP53	ENSUAMP00000011671	ENSUAMP00000000913	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.965
C17orf113	TP53	ENSUAMP00000032171	ENSUAMP00000000913	Chromosome 17 open reading frame 113.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.460
ENSUAMP00000003796	TP53	ENSUAMP00000003796	ENSUAMP00000000913	C2H2-type domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.460
ENSUAMP00000007110	TP53	ENSUAMP00000007110	ENSUAMP00000000913	BEN domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.688
ENSUAMP00000007110	TP63	ENSUAMP00000007110	ENSUAMP00000007724	BEN domain-containing protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.458
ENSUAMP00000007110	TP73	ENSUAMP00000007110	ENSUAMP00000015024	BEN domain-containing protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.458
ENSUAMP00000007117	TP53	ENSUAMP00000007117	ENSUAMP00000000913	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.688
ENSUAMP00000007117	TP63	ENSUAMP00000007117	ENSUAMP00000007724	Uncharacterized protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.458
ENSUAMP00000007117	TP73	ENSUAMP00000007117	ENSUAMP00000015024	Uncharacterized protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.458