STRINGSTRING
ENSUAMP00000028265 ENSUAMP00000028265 AKT2 AKT2 ENSUAMP00000037175 ENSUAMP00000037175 SALL2 SALL2 PSMD12 PSMD12 MAF1 MAF1 ENSUAMP00000036637 ENSUAMP00000036637 NPTX1 NPTX1 LAMTOR1 LAMTOR1 PSMD4 PSMD4 MTA2 MTA2 RHEBL1 RHEBL1 RING1 RING1 ATN1 ATN1 RNF146 RNF146 SNAI1 SNAI1 GUF1 GUF1 EED EED PSMA2 PSMA2 PSMB7 PSMB7 PML PML PSMA7 PSMA7 ENSUAMP00000032923 ENSUAMP00000032923 PHC3 PHC3 CHD5 CHD5 NPTXR NPTXR CBX6 CBX6 PSME2 PSME2 PSME1 PSME1 TRIM27 TRIM27 MKRN2 MKRN2 PSMA6 PSMA6 SCMH1 SCMH1 PSMC6 PSMC6 SLC38A9 SLC38A9 ENSUAMP00000029725 ENSUAMP00000029725 EZH2 EZH2 RNF141 RNF141 RNF2 RNF2 PSMB10 PSMB10 USP7 USP7 ENSUAMP00000026056 ENSUAMP00000026056 SNAI3 SNAI3 RERE RERE PSMA1 PSMA1 ENSUAMP00000025192 ENSUAMP00000025192 PSMC2 PSMC2 PSMB4 PSMB4 NPTX2 NPTX2 ENSUAMP00000023081 ENSUAMP00000023081 PSMA4 PSMA4 MTA3 MTA3 ENSUAMP00000022022 ENSUAMP00000022022 LAMTOR5 LAMTOR5 ENSUAMP00000021443 ENSUAMP00000021443 CSNK2A2 CSNK2A2 TNKS2 TNKS2 CBX4 CBX4 CBX8 CBX8 PSMD5 PSMD5 RRAGD RRAGD ENSUAMP00000020715 ENSUAMP00000020715 KXD1 KXD1 PSMD10 PSMD10 TRIM7 TRIM7 ENSUAMP00000019846 ENSUAMP00000019846 PSMD3 PSMD3 MTOR MTOR ENSUAMP00000019292 ENSUAMP00000019292 SNAI2 SNAI2 MBD3 MBD3 HDAC1 HDAC1 SUZ12 SUZ12 ENSUAMP00000017922 ENSUAMP00000017922 ENSUAMP00000017773 ENSUAMP00000017773 PSMD8 PSMD8 MKRN1 MKRN1 PSMB9 PSMB9 PSMB8 PSMB8 PSMD13 PSMD13 USP13 USP13 PSME3 PSME3 TNKS TNKS FRK FRK STUB1 STUB1 ENSUAMP00000015431 ENSUAMP00000015431 ENSUAMP00000014875 ENSUAMP00000014875 PHC2 PHC2 OTUD3 OTUD3 MTA1 MTA1 SALL4 SALL4 ENSUAMP00000012220 ENSUAMP00000012220 PREX2 PREX2 AKT3 AKT3 CRYBB3 CRYBB3 ENSUAMP00000011151 ENSUAMP00000011151 ENSUAMP00000011054 ENSUAMP00000011054 AKT1 AKT1 PSMD9 PSMD9 PSMB5 PSMB5 ENSUAMP00000010232 ENSUAMP00000010232 PSME4 PSME4 MECOM MECOM ENSUAMP00000009766 ENSUAMP00000009766 ENSUAMP00000009702 ENSUAMP00000009702 PSMD7 PSMD7 WWP2 WWP2 RBBP7 RBBP7 SCML2 SCML2 RRAGC RRAGC PSMA3 PSMA3 OTUD4 OTUD4 PSMC5 PSMC5 EZH1 EZH1 TNRC6B TNRC6B GATAD2B GATAD2B PSMF1 PSMF1 PSMB11 PSMB11 CHD3 CHD3 PSMB3 PSMB3 PSMB6 PSMB6 PSMC3 PSMC3 ENSUAMP00000005735 ENSUAMP00000005735 AIRE AIRE RRAGB RRAGB ENSUAMP00000005084 ENSUAMP00000005084 MLST8 MLST8 CBX7 CBX7 ENSUAMP00000004531 ENSUAMP00000004531 ENSUAMP00000004313 ENSUAMP00000004313 LAMTOR3 LAMTOR3 PSMB1 PSMB1 ENSUAMP00000003372 ENSUAMP00000003372 RHEB RHEB CRYGN CRYGN XIAP XIAP ENSUAMP00000002733 ENSUAMP00000002733 ENSUAMP00000002604 ENSUAMP00000002604 PSMD11 PSMD11 PSMD2 PSMD2 PSMD1 PSMD1 RRAGA RRAGA PSMC4 PSMC4 ENSUAMP00000001828 ENSUAMP00000001828 HDAC2 HDAC2 PSMB2 PSMB2 ENSUAMP00000000970 ENSUAMP00000000970 GATAD2A GATAD2A EGR1 EGR1 ENSUAMP00000000292 ENSUAMP00000000292 ENSUAMP00000000198 ENSUAMP00000000198
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000028265RING-type domain-containing protein. (357 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037175MPN domain-containing protein. (156 aa)
SALL2Spalt like transcription factor 2. (1041 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
MAF1Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (260 aa)
ENSUAMP00000036637PCI domain-containing protein. (405 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (174 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (344 aa)
MTA2Metastasis associated 1 family member 2. (668 aa)
RHEBL1RHEB like 1. (183 aa)
RING1Ring finger protein 1. (406 aa)
ATN1Atrophin 1. (1206 aa)
RNF146Ring finger protein 146. (362 aa)
SNAI1Snail family transcriptional repressor 1. (259 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (669 aa)
EEDEmbryonic ectoderm development. (441 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMB7Proteasome subunit beta. (277 aa)
PMLPromyelocytic leukemia. (877 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
PHC3Polyhomeotic homolog 3. (995 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1942 aa)
NPTXRNeuronal pentraxin receptor. (476 aa)
CBX6Chromobox 6. (415 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSME1Proteasome activator subunit 1. (249 aa)
TRIM27Tripartite motif containing 27. (513 aa)
MKRN2Makorin ring finger protein 2. (416 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
SCMH1Scm polycomb group protein homolog 1. (582 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
SLC38A9Solute carrier family 38 member 9. (562 aa)
ENSUAMP00000029725Uncharacterized protein. (1947 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
RNF141Ring finger protein 141. (230 aa)
RNF2Ring finger protein 2. (336 aa)
PSMB10Proteasome subunit beta 10. (327 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1055 aa)
ENSUAMP00000026056MitMem_reg domain-containing protein. (95 aa)
SNAI3Snail family transcriptional repressor 3. (291 aa)
REREArginine-glutamic acid dipeptide repeats. (1309 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
ENSUAMP00000025192Ubiquitin-like domain-containing protein. (156 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
NPTX2Neuronal pentraxin 2. (413 aa)
ENSUAMP00000023081Uncharacterized protein. (228 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
MTA3Metastasis associated 1 family member 3. (589 aa)
ENSUAMP00000022022Uncharacterized protein. (107 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
ENSUAMP00000021443Ubiquitin-like domain-containing protein. (77 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (322 aa)
TNKS2Poly [ADP-ribose] polymerase. (1276 aa)
CBX4Chromobox 4. (486 aa)
CBX8Chromobox 8. (352 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
RRAGDRas related GTP binding D. (426 aa)
ENSUAMP00000020715Ubiquitin-like domain-containing protein. (132 aa)
KXD1KxDL motif containing 1. (128 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (151 aa)
TRIM7Tripartite motif containing 7. (501 aa)
ENSUAMP00000019846Robl_LC7 domain-containing protein. (259 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
ENSUAMP00000019292Thioredoxin domain-containing protein. (141 aa)
SNAI2Snail family transcriptional repressor 2. (230 aa)
MBD3Methyl-CpG binding domain protein 3. (295 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (900 aa)
ENSUAMP00000017922C3H1-type domain-containing protein. (220 aa)
ENSUAMP00000017773CAF1C_H4-bd domain-containing protein. (87 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
MKRN1Makorin ring finger protein 1. (484 aa)
PSMB9Proteasome subunit beta. (220 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (586 aa)
PSME3Proteasome activator subunit 3. (254 aa)
TNKSPoly [ADP-ribose] polymerase. (908 aa)
FRKTyrosine-protein kinase. (515 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
ENSUAMP00000015431Uncharacterized protein. (297 aa)
ENSUAMP00000014875Uncharacterized protein. (837 aa)
PHC2Polyhomeotic homolog 2. (826 aa)
OTUD3OTU deubiquitinase 3. (398 aa)
MTA1Metastasis associated 1. (741 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
ENSUAMP00000012220ATPase_AAA_core domain-containing protein. (174 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1261 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
ENSUAMP00000011151Uncharacterized protein. (596 aa)
ENSUAMP00000011054Uncharacterized protein. (177 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PSMD9PDZ domain-containing protein. (309 aa)
PSMB5Proteasome subunit beta. (263 aa)
ENSUAMP00000010232Ubiquitin-like domain-containing protein. (88 aa)
PSME4Proteasome activator subunit 4. (1436 aa)
MECOMMDS1 and EVI1 complex locus. (1120 aa)
ENSUAMP00000009766Uncharacterized protein. (462 aa)
ENSUAMP00000009702Uncharacterized protein. (216 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (427 aa)
SCML2Scm polycomb group protein like 2. (675 aa)
RRAGCRas related GTP binding C. (399 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
OTUD4OTU deubiquitinase 4. (1096 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1802 aa)
GATAD2BGATA zinc finger domain containing 2B. (593 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMB11Proteasome subunit beta. (292 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1838 aa)
PSMB3Proteasome subunit beta. (202 aa)
PSMB6Proteasome subunit beta. (219 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
ENSUAMP00000005735PROTEASOME_ALPHA_1 domain-containing protein. (80 aa)
AIREAutoimmune regulator. (542 aa)
RRAGBRas related GTP binding B. (346 aa)
ENSUAMP00000005084Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (385 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
CBX7Chromobox 7. (250 aa)
ENSUAMP00000004531AAA domain-containing protein; Belongs to the AAA ATPase family. (421 aa)
ENSUAMP00000004313Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (64 aa)
LAMTOR3Uncharacterized protein. (124 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSUAMP00000003372Uncharacterized protein. (157 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (183 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
ENSUAMP00000002733Uncharacterized protein. (140 aa)
ENSUAMP00000002604CAF1C_H4-bd domain-containing protein. (133 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (418 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (683 aa)
RRAGARas related GTP binding A. (308 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (400 aa)
ENSUAMP00000001828Uncharacterized protein. (91 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (446 aa)
PSMB2Proteasome subunit beta. (167 aa)
ENSUAMP00000000970Uncharacterized protein. (294 aa)
GATAD2AGATA zinc finger domain containing 2A. (639 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
ENSUAMP00000000292PCI domain-containing protein. (389 aa)
ENSUAMP00000000198Uncharacterized protein. (238 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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