STRINGSTRING
PSMB6 PSMB6 PSMA2 PSMA2 PSMB7 PSMB7 PSMA7 PSMA7 ZNF385C ZNF385C C17orf113 C17orf113 PSME2 PSME2 PSME1 PSME1 ENSUAMP00000031131 ENSUAMP00000031131 CDC25A CDC25A PSMA6 PSMA6 PSMC6 PSMC6 ZNF385A ZNF385A CDKN1A CDKN1A ENSUAMP00000028080 ENSUAMP00000028080 ENSUAMP00000027431 ENSUAMP00000027431 ENSUAMP00000027429 ENSUAMP00000027429 PSMB10 PSMB10 ENSUAMP00000026056 ENSUAMP00000026056 PSMA1 PSMA1 ENSUAMP00000025192 ENSUAMP00000025192 PSMC2 PSMC2 PSMB4 PSMB4 MDM2 MDM2 PSMA4 PSMA4 ENSUAMP00000022022 ENSUAMP00000022022 ENSUAMP00000021443 ENSUAMP00000021443 PSMD5 PSMD5 ENSUAMP00000020715 ENSUAMP00000020715 KXD1 KXD1 PSMD10 PSMD10 PSMD3 PSMD3 ENSUAMP00000018470 ENSUAMP00000018470 PSMD8 PSMD8 PSMB9 PSMB9 PSMB8 PSMB8 PSMD13 PSMD13 PHF20 PHF20 PSME3 PSME3 CHEK2 CHEK2 CCNA2 CCNA2 ENSUAMP00000012220 ENSUAMP00000012220 PSMD9 PSMD9 ENSUAMP00000010431 ENSUAMP00000010431 PSMB5 PSMB5 ENSUAMP00000010232 ENSUAMP00000010232 PSME4 PSME4 PSMD7 PSMD7 PSMA3 PSMA3 PSMC5 PSMC5 ENSUAMP00000008823 ENSUAMP00000008823 CCNE1 CCNE1 MDM4 MDM4 PSMF1 PSMF1 CDKN1B CDKN1B PSMB11 PSMB11 CHEK1 CHEK1 PSMB3 PSMB3 PSMC3 PSMC3 ENSUAMP00000005735 ENSUAMP00000005735 ENSUAMP00000004964 ENSUAMP00000004964 CDK3 CDK3 ENSUAMP00000004531 ENSUAMP00000004531 ENSUAMP00000003796 ENSUAMP00000003796 PSMB1 PSMB1 ENSUAMP00000003372 ENSUAMP00000003372 CCNA1 CCNA1 PSMD11 PSMD11 PSMD2 PSMD2 PSMD1 PSMD1 PSMC4 PSMC4 ENSUAMP00000001524 ENSUAMP00000001524 PSMB2 PSMB2 TP53 TP53 ENSUAMP00000000292 ENSUAMP00000000292 ENSUAMP00000037175 ENSUAMP00000037175 PSMD12 PSMD12 ENSUAMP00000036637 ENSUAMP00000036637 PSMD4 PSMD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB6Proteasome subunit beta. (219 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
ZNF385CZinc finger protein 385C. (422 aa)
C17orf113Chromosome 17 open reading frame 113. (639 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSME1Proteasome activator subunit 1. (249 aa)
ENSUAMP00000031131Protein kinase domain-containing protein. (264 aa)
CDC25ACell division cycle 25A. (498 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
ZNF385AZinc finger protein 385A. (386 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000028080Uncharacterized protein. (291 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
ENSUAMP00000027429Uncharacterized protein. (165 aa)
PSMB10Proteasome subunit beta 10. (327 aa)
ENSUAMP00000026056MitMem_reg domain-containing protein. (95 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
ENSUAMP00000025192Ubiquitin-like domain-containing protein. (156 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
ENSUAMP00000022022Uncharacterized protein. (107 aa)
ENSUAMP00000021443Ubiquitin-like domain-containing protein. (77 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
ENSUAMP00000020715Ubiquitin-like domain-containing protein. (132 aa)
KXD1KxDL motif containing 1. (128 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (151 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
ENSUAMP00000018470Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
PSMB9Proteasome subunit beta. (220 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PHF20PHD finger protein 20. (1001 aa)
PSME3Proteasome activator subunit 3. (254 aa)
CHEK2Checkpoint kinase 2. (530 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (425 aa)
ENSUAMP00000012220ATPase_AAA_core domain-containing protein. (174 aa)
PSMD9PDZ domain-containing protein. (309 aa)
ENSUAMP00000010431Uncharacterized protein. (415 aa)
PSMB5Proteasome subunit beta. (263 aa)
ENSUAMP00000010232Ubiquitin-like domain-containing protein. (88 aa)
PSME4Proteasome activator subunit 4. (1436 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
PSMB11Proteasome subunit beta. (292 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
PSMB3Proteasome subunit beta. (202 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
ENSUAMP00000005735PROTEASOME_ALPHA_1 domain-containing protein. (80 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
ENSUAMP00000004531AAA domain-containing protein; Belongs to the AAA ATPase family. (421 aa)
ENSUAMP00000003796C2H2-type domain-containing protein. (240 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSUAMP00000003372Uncharacterized protein. (157 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (447 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (418 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (683 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (400 aa)
ENSUAMP00000001524Uncharacterized protein. (75 aa)
PSMB2Proteasome subunit beta. (167 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000000292PCI domain-containing protein. (389 aa)
ENSUAMP00000037175MPN domain-containing protein. (156 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ENSUAMP00000036637PCI domain-containing protein. (405 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (344 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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