STRINGSTRING
ENSUAMP00000026055 ENSUAMP00000026055 SLC16A8 SLC16A8 RXRA RXRA PDHX PDHX FAM114A2 FAM114A2 ENSUAMP00000028021 ENSUAMP00000028021 MPC1L MPC1L ENSUAMP00000028798 ENSUAMP00000028798 ACO2 ACO2 PDP1 PDP1 ENSUAMP00000031664 ENSUAMP00000031664 PDK1 PDK1 PDHA1 PDHA1 SDHB SDHB ENSUAMP00000033428 ENSUAMP00000033428 ENSUAMP00000033767 ENSUAMP00000033767 CS CS ENSUAMP00000001439 ENSUAMP00000001439 PDPR PDPR SUCLA2 SUCLA2 ENSUAMP00000003971 ENSUAMP00000003971 SUCLG1 SUCLG1 ENSUAMP00000005190 ENSUAMP00000005190 ENSUAMP00000005719 ENSUAMP00000005719 IDH3B IDH3B LACTB2 LACTB2 PDK4 PDK4 PDP2 PDP2 VDAC1 VDAC1 MBLAC2 MBLAC2 ENSUAMP00000009430 ENSUAMP00000009430 IDH2 IDH2 MPC2 MPC2 D2HGDH D2HGDH ENSUAMP00000010334 ENSUAMP00000010334 ENSUAMP00000011425 ENSUAMP00000011425 MPC1 MPC1 ENSUAMP00000011619 ENSUAMP00000011619 ENSUAMP00000012538 ENSUAMP00000012538 ENSUAMP00000012541 ENSUAMP00000012541 DLD DLD MDH2 MDH2 SLC16A3 SLC16A3 GSTZ1 GSTZ1 ENSUAMP00000014859 ENSUAMP00000014859 GLO1 GLO1 NNT NNT L2HGDH L2HGDH HAGHL HAGHL ME1 ME1 HAGH HAGH FAHD1 FAHD1 ENSUAMP00000017059 ENSUAMP00000017059 ENSUAMP00000017482 ENSUAMP00000017482 OGDH OGDH PPARD PPARD SLC16A1 SLC16A1 ME2 ME2 OGDHL OGDHL IDH3G IDH3G IDH3A IDH3A DLAT DLAT ENSUAMP00000023721 ENSUAMP00000023721 LDHAL6B LDHAL6B ENSUAMP00000024472 ENSUAMP00000024472 ENSUAMP00000000220 ENSUAMP00000000220 PNKD PNKD PDK2 PDK2 PDHB PDHB PDHA2 PDHA2 ENSUAMP00000024473 ENSUAMP00000024473 LDHA LDHA FH FH ENSUAMP00000024931 ENSUAMP00000024931 PDK3 PDK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000026055Ldh_1_C domain-containing protein. (101 aa)
SLC16A8Solute carrier family 16 member 8. (477 aa)
RXRARetinoid X receptor alpha. (469 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
FAM114A2Family with sequence similarity 114 member A2. (472 aa)
ENSUAMP00000028021Uncharacterized protein. (135 aa)
MPC1LMitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (134 aa)
ENSUAMP00000028798Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (799 aa)
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (591 aa)
ENSUAMP00000031664annotation not available (372 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (254 aa)
ENSUAMP00000033428Uncharacterized protein. (169 aa)
ENSUAMP00000033767Uncharacterized protein. (60 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
ENSUAMP00000001439Ldh_1_C domain-containing protein. (58 aa)
PDPRPyruvate dehydrogenase phosphatase regulatory subunit. (872 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
ENSUAMP00000003971Ldh_1_C domain-containing protein. (101 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
ENSUAMP00000005190Ldh_1_N domain-containing protein. (221 aa)
ENSUAMP00000005719Ldh_1_N domain-containing protein. (127 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
LACTB2Lactamase beta 2. (272 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
PDP2Pyruvate dehyrogenase phosphatase catalytic subunit 2. (539 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
MBLAC2Metallo-beta-lactamase domain containing 2. (279 aa)
ENSUAMP00000009430Uncharacterized protein. (268 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (421 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (116 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (543 aa)
ENSUAMP00000010334Fe-ADH domain-containing protein. (433 aa)
ENSUAMP00000011425Malic domain-containing protein. (254 aa)
MPC1Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (66 aa)
ENSUAMP00000011619Malic_M domain-containing protein. (256 aa)
ENSUAMP000000125382-oxoacid_dh domain-containing protein. (170 aa)
ENSUAMP00000012541Uncharacterized protein. (98 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
MDH2Malate dehydrogenase. (338 aa)
SLC16A3Solute carrier family 16 member 3. (460 aa)
GSTZ1Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (213 aa)
ENSUAMP00000014859Iso_dh domain-containing protein. (372 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (212 aa)
NNTNicotinamide nucleotide transhydrogenase. (740 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase. (463 aa)
HAGHLHydroxyacylglutathione hydrolase like. (283 aa)
ME1Malic enzyme. (580 aa)
HAGHHydroxyacylglutathione hydrolase. (364 aa)
FAHD1Fumarylacetoacetate hydrolase domain containing 1. (221 aa)
ENSUAMP000000170592-oxoacid_dh domain-containing protein. (248 aa)
ENSUAMP00000017482Uncharacterized protein. (228 aa)
OGDHOxoglutarate dehydrogenase. (1083 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SLC16A1Solute carrier family 16 member 1. (498 aa)
ME2Malic enzyme. (547 aa)
OGDHLOxoglutarate dehydrogenase like. (1025 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (395 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (380 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
ENSUAMP00000023721Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
LDHAL6BL-lactate dehydrogenase. (236 aa)
ENSUAMP00000024472Ldh_1_C domain-containing protein. (55 aa)
ENSUAMP00000000220Uncharacterized protein. (142 aa)
PNKDPNKD metallo-beta-lactamase domain containing. (360 aa)
PDK2Protein-serine/threonine kinase. (249 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
ENSUAMP00000024473L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (179 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
FHFumarate hydratase. (493 aa)
ENSUAMP00000024931Uncharacterized protein. (162 aa)
PDK3Protein-serine/threonine kinase. (382 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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