STRINGSTRING
POLDIP3 POLDIP3 ENSUAMP00000000194 ENSUAMP00000000194 ENSUAMP00000001138 ENSUAMP00000001138 ENSUAMP00000001657 ENSUAMP00000001657 ZNF473 ZNF473 ENSUAMP00000003044 ENSUAMP00000003044 ENSUAMP00000003643 ENSUAMP00000003643 ENSUAMP00000003688 ENSUAMP00000003688 SRSF6 SRSF6 ENSUAMP00000003932 ENSUAMP00000003932 CHTOP CHTOP TPRG1 TPRG1 RNPS1 RNPS1 THOC1 THOC1 ENSUAMP00000005947 ENSUAMP00000005947 ENSUAMP00000006021 ENSUAMP00000006021 NCBP1 NCBP1 ENSUAMP00000006421 ENSUAMP00000006421 ENSUAMP00000006861 ENSUAMP00000006861 ZNF318 ZNF318 SRSF4 SRSF4 CPSF1 CPSF1 NCBP2L NCBP2L CPSF3 CPSF3 CPSF4L CPSF4L THOC6 THOC6 CPSF4 CPSF4 SNRPF SNRPF ENSUAMP00000010072 ENSUAMP00000010072 ENSUAMP00000010189 ENSUAMP00000010189 ENSUAMP00000010191 ENSUAMP00000010191 ENSUAMP00000011245 ENSUAMP00000011245 PCF11 PCF11 ENSUAMP00000011648 ENSUAMP00000011648 MAGOH MAGOH ENSUAMP00000012147 ENSUAMP00000012147 SNRPE SNRPE THOC3 THOC3 SNRPD3 SNRPD3 CLP1 CLP1 THOC2 THOC2 ENSUAMP00000014226 ENSUAMP00000014226 ENSUAMP00000014628 ENSUAMP00000014628 TPRG1L TPRG1L FIP1L1 FIP1L1 SLBP SLBP LSM11 LSM11 SRSF2 SRSF2 THOC5 THOC5 SRSF5 SRSF5 ENSUAMP00000019105 ENSUAMP00000019105 CASC3 CASC3 SRSF9 SRSF9 WDR25 WDR25 ENSUAMP00000020844 ENSUAMP00000020844 ENSUAMP00000021295 ENSUAMP00000021295 ALYREF ALYREF NUDT21 NUDT21 C12orf50 C12orf50 CPSF7 CPSF7 SRSF3 SRSF3 CSTF1 CSTF1 U2AF2 U2AF2 DDX39A DDX39A LSM10 LSM10 ENSUAMP00000026187 ENSUAMP00000026187 DHX38 DHX38 ENSUAMP00000026751 ENSUAMP00000026751 ENSUAMP00000026961 ENSUAMP00000026961 CDC40 CDC40 ENSUAMP00000028028 ENSUAMP00000028028 ENSUAMP00000028165 ENSUAMP00000028165 RBM8A RBM8A ENSUAMP00000029411 ENSUAMP00000029411 ENSUAMP00000029412 ENSUAMP00000029412 SYMPK SYMPK CPSF6 CPSF6 NCBP2 NCBP2 PABPN1 PABPN1 UPF3B UPF3B ENSUAMP00000032859 ENSUAMP00000032859 ENSUAMP00000033339 ENSUAMP00000033339 PAPOLA PAPOLA ENSUAMP00000033911 ENSUAMP00000033911 CSTF2 CSTF2 DDX39B DDX39B EIF4A3 EIF4A3 WDR33 WDR33 CPSF2 CPSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLDIP3DNA polymerase delta interacting protein 3. (421 aa)
ENSUAMP00000000194SLBP_RNA_bind domain-containing protein. (203 aa)
ENSUAMP00000001138Sm domain-containing protein. (85 aa)
ENSUAMP00000001657Uncharacterized protein. (70 aa)
ZNF473Zinc finger protein 473. (729 aa)
ENSUAMP00000003044Uncharacterized protein. (204 aa)
ENSUAMP00000003643Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (72 aa)
ENSUAMP00000003688Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (78 aa)
SRSF6Serine and arginine rich splicing factor 6. (344 aa)
ENSUAMP00000003932Uncharacterized protein. (99 aa)
CHTOPChromatin target of PRMT1. (248 aa)
TPRG1Tumor protein p63 regulated 1. (279 aa)
RNPS1RRM domain-containing protein. (283 aa)
THOC1THO complex 1. (792 aa)
ENSUAMP00000005947annotation not available (78 aa)
ENSUAMP00000006021Uncharacterized protein. (124 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
ENSUAMP00000006421Uncharacterized protein. (273 aa)
ENSUAMP00000006861Sm domain-containing protein. (52 aa)
ZNF318Zinc finger protein 318. (2084 aa)
SRSF4Serine and arginine rich splicing factor 4. (497 aa)
CPSF1Cleavage and polyadenylation specific factor 1. (1423 aa)
NCBP2LNuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (162 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (696 aa)
CPSF4LCleavage and polyadenylation specific factor 4 like. (157 aa)
THOC6THO complex 6. (341 aa)
CPSF4Cleavage and polyadenylation specific factor 4. (259 aa)
SNRPFSm domain-containing protein. (86 aa)
ENSUAMP00000010072Sm domain-containing protein. (105 aa)
ENSUAMP00000010189RRM domain-containing protein. (130 aa)
ENSUAMP00000010191Uncharacterized protein. (256 aa)
ENSUAMP00000011245Uncharacterized protein. (315 aa)
PCF11PCF11 cleavage and polyadenylation factor subunit. (1686 aa)
ENSUAMP00000011648Uncharacterized protein. (243 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
ENSUAMP00000012147Uncharacterized protein. (248 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (88 aa)
THOC3THO complex 3. (351 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
THOC2THO complex 2. (1592 aa)
ENSUAMP00000014226RRM domain-containing protein. (148 aa)
ENSUAMP00000014628PWI domain-containing protein. (90 aa)
TPRG1LTumor protein p63 regulated 1 like. (250 aa)
FIP1L1Factor interacting with PAPOLA and CPSF1. (516 aa)
SLBPStem-loop binding protein. (277 aa)
LSM11LSM11, U7 small nuclear RNA associated. (335 aa)
SRSF2RRM domain-containing protein. (221 aa)
THOC5THO complex 5. (660 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
ENSUAMP00000019105SAP domain-containing protein. (191 aa)
CASC3CASC3 exon junction complex subunit. (704 aa)
SRSF9Serine and arginine rich splicing factor 9. (221 aa)
WDR25WD repeat domain 25. (477 aa)
ENSUAMP00000020844Uncharacterized protein. (68 aa)
ENSUAMP00000021295Uncharacterized protein. (103 aa)
ALYREFAly/REF export factor. (253 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (229 aa)
C12orf50Chromosome 12 open reading frame 50. (415 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (477 aa)
SRSF3Serine and arginine rich splicing factor 3. (156 aa)
CSTF1Cleavage stimulation factor subunit 1. (431 aa)
U2AF2U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (455 aa)
DDX39ADExD-box helicase 39A. (427 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
ENSUAMP00000026187Sm domain-containing protein. (72 aa)
DHX38DEAH-box helicase 38. (1228 aa)
ENSUAMP00000026751Uncharacterized protein. (220 aa)
ENSUAMP00000026961Uncharacterized protein. (113 aa)
CDC40Cell division cycle 40. (318 aa)
ENSUAMP00000028028Sm domain-containing protein. (48 aa)
ENSUAMP00000028165Uncharacterized protein. (117 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
ENSUAMP00000029411RRM domain-containing protein. (195 aa)
ENSUAMP00000029412RRM domain-containing protein. (109 aa)
SYMPKSymplekin. (1277 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (499 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (163 aa)
PABPN1RRM domain-containing protein. (306 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (467 aa)
ENSUAMP00000032859Uncharacterized protein. (137 aa)
ENSUAMP00000033339Uncharacterized protein. (1504 aa)
PAPOLAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (427 aa)
ENSUAMP00000033911Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
CSTF2Cleavage stimulation factor subunit 2. (631 aa)
DDX39BDExD-box helicase 39B. (412 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
WDR33WD repeat domain 33. (1336 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (787 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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