STRINGSTRING
USP31 USP31 USP10 USP10 POLE2 POLE2 TRIM47 TRIM47 TRIM65 TRIM65 POLD2 POLD2 ENSUAMP00000006705 ENSUAMP00000006705 CUL4B CUL4B UFD1 UFD1 POLK POLK ENSUAMP00000010232 ENSUAMP00000010232 ENSUAMP00000010934 ENSUAMP00000010934 ENSUAMP00000011011 ENSUAMP00000011011 ENSUAMP00000011715 ENSUAMP00000011715 RCBTB1 RCBTB1 ENSUAMP00000011742 ENSUAMP00000011742 ENSUAMP00000011763 ENSUAMP00000011763 ENSUAMP00000012031 ENSUAMP00000012031 CUL4A CUL4A SPRTN SPRTN ENSUAMP00000013008 ENSUAMP00000013008 RCBTB2 RCBTB2 PCNA PCNA ENSUAMP00000017619 ENSUAMP00000017619 POLD1 POLD1 POLI POLI RFC4 RFC4 KXD1 KXD1 ENSUAMP00000020715 ENSUAMP00000020715 REV3L REV3L RPA1 RPA1 NPLOC4 NPLOC4 ENSUAMP00000021443 ENSUAMP00000021443 USP43 USP43 ENSUAMP00000022046 ENSUAMP00000022046 RCHY1 RCHY1 DDB1 DDB1 POLE3 POLE3 MAD2L2 MAD2L2 ENSUAMP00000025192 ENSUAMP00000025192 RFC3 RFC3 WDR48 WDR48 USP1 USP1 DTL DTL ENSUAMP00000028972 ENSUAMP00000028972 SPATA5 SPATA5 ENSUAMP00000030711 ENSUAMP00000030711 RBX1 RBX1 ENSUAMP00000031071 ENSUAMP00000031071 VCP VCP POLE4 POLE4 ENSUAMP00000031776 ENSUAMP00000031776 ENSUAMP00000031944 ENSUAMP00000031944 RFC2 RFC2 SPATA5L1 SPATA5L1 ENSUAMP00000033611 ENSUAMP00000033611 RFC5 RFC5 ISG15 ISG15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
USP31Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1258 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (793 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (507 aa)
TRIM47Tripartite motif containing 47. (642 aa)
TRIM65Tripartite motif containing 65. (521 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
ENSUAMP00000006705Uncharacterized protein. (266 aa)
CUL4BCullin 4B; Belongs to the cullin family. (879 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
POLKDNA polymerase kappa. (542 aa)
ENSUAMP00000010232Ubiquitin-like domain-containing protein. (88 aa)
ENSUAMP00000010934Uncharacterized protein. (48 aa)
ENSUAMP00000011011Uncharacterized protein. (465 aa)
ENSUAMP00000011715DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (404 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ENSUAMP00000011742DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (667 aa)
ENSUAMP00000011763DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (295 aa)
ENSUAMP00000012031SAP domain-containing protein. (314 aa)
CUL4ACullin 4A; Belongs to the cullin family. (863 aa)
SPRTNSprT-like N-terminal domain. (509 aa)
ENSUAMP00000013008Uncharacterized protein. (603 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ENSUAMP00000017619UmuC domain-containing protein. (558 aa)
POLD1DNA polymerase. (1109 aa)
POLIDNA polymerase iota. (718 aa)
RFC4Replication factor C subunit 4. (363 aa)
KXD1KxDL motif containing 1. (128 aa)
ENSUAMP00000020715Ubiquitin-like domain-containing protein. (132 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (2648 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (592 aa)
ENSUAMP00000021443Ubiquitin-like domain-containing protein. (77 aa)
USP43Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1032 aa)
ENSUAMP00000022046RFC1 domain-containing protein. (138 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
DDB1Damage specific DNA binding protein 1. (1151 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
ENSUAMP00000025192Ubiquitin-like domain-containing protein. (156 aa)
RFC3Replication factor C subunit 3. (185 aa)
WDR48WD repeat domain 48. (626 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (786 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
ENSUAMP00000028972Uncharacterized protein. (262 aa)
SPATA5Spermatogenesis associated 5. (756 aa)
ENSUAMP00000030711Cullin domain-containing protein; Belongs to the cullin family. (274 aa)
RBX1Ring-box 1. (108 aa)
ENSUAMP00000031071Replication factor C subunit 1. (1147 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (115 aa)
ENSUAMP00000031776Uncharacterized protein. (122 aa)
ENSUAMP00000031944Uncharacterized protein. (79 aa)
RFC2Replication factor C subunit 2. (368 aa)
SPATA5L1Spermatogenesis associated 5 like 1. (755 aa)
ENSUAMP00000033611UmuC domain-containing protein. (188 aa)
RFC5Replication factor C subunit 5. (255 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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