65 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRYGN	Crystallin gamma N; Belongs to the beta/gamma-crystallin family. (183 aa)
	SALL2	Spalt like transcription factor 2. (1041 aa)
	MAF1	Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (260 aa)
	NPTX1	Neuronal pentraxin 1. (432 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (174 aa)
	MTA2	Metastasis associated 1 family member 2. (668 aa)
	RHEBL1	RHEB like 1. (183 aa)
	RING1	Ring finger protein 1. (406 aa)
	ATN1	Atrophin 1. (1206 aa)
	SNAI1	Snail family transcriptional repressor 1. (259 aa)
	EED	Embryonic ectoderm development. (441 aa)
	PHC3	Polyhomeotic homolog 3. (995 aa)
	CHD5	Chromodomain helicase DNA binding protein 5. (1942 aa)
	NPTXR	Neuronal pentraxin receptor. (476 aa)
	CBX6	Chromobox 6. (415 aa)
	SCMH1	Scm polycomb group protein homolog 1. (582 aa)
	SLC38A9	Solute carrier family 38 member 9. (562 aa)
	ENSUAMP00000029725	Uncharacterized protein. (1947 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	ENSUAMP00000028265	RING-type domain-containing protein. (357 aa)
	RNF2	Ring finger protein 2. (336 aa)
	SNAI3	Snail family transcriptional repressor 3. (291 aa)
	RERE	Arginine-glutamic acid dipeptide repeats. (1309 aa)
	NPTX2	Neuronal pentraxin 2. (413 aa)
	ENSUAMP00000023081	Uncharacterized protein. (228 aa)
	MTA3	Metastasis associated 1 family member 3. (589 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
	CBX4	Chromobox 4. (486 aa)
	CBX8	Chromobox 8. (352 aa)
	RRAGD	Ras related GTP binding D. (426 aa)
	ENSUAMP00000019846	Robl_LC7 domain-containing protein. (259 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
	ENSUAMP00000019292	Thioredoxin domain-containing protein. (141 aa)
	SNAI2	Snail family transcriptional repressor 2. (230 aa)
	MBD3	Methyl-CpG binding domain protein 3. (295 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (900 aa)
	ENSUAMP00000017773	CAF1C_H4-bd domain-containing protein. (87 aa)
	ENSUAMP00000014875	Uncharacterized protein. (837 aa)
	PHC2	Polyhomeotic homolog 2. (826 aa)
	MTA1	Metastasis associated 1. (741 aa)
	SALL4	Spalt like transcription factor 4. (1053 aa)
	CRYBB3	Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
	ENSUAMP00000011151	Uncharacterized protein. (596 aa)
	ENSUAMP00000011054	Uncharacterized protein. (177 aa)
	MECOM	MDS1 and EVI1 complex locus. (1120 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (427 aa)
	SCML2	Scm polycomb group protein like 2. (675 aa)
	RRAGC	Ras related GTP binding C. (399 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
	GATAD2B	GATA zinc finger domain containing 2B. (593 aa)
	CHD3	Chromodomain helicase DNA binding protein 3. (1838 aa)
	AIRE	Autoimmune regulator. (542 aa)
	RRAGB	Ras related GTP binding B. (346 aa)
	MLST8	MTOR associated protein, LST8 homolog. (326 aa)
	CBX7	Chromobox 7. (250 aa)
	LAMTOR3	Uncharacterized protein. (124 aa)
	RHEB	Ras homolog, mTORC1 binding. (179 aa)
	ENSUAMP00000002733	Uncharacterized protein. (140 aa)
	ENSUAMP00000002604	CAF1C_H4-bd domain-containing protein. (133 aa)
	RRAGA	Ras related GTP binding A. (308 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (446 aa)
	ENSUAMP00000000970	Uncharacterized protein. (294 aa)
	GATAD2A	GATA zinc finger domain containing 2A. (639 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIRE	ENSUAMP00000002604	ENSUAMP00000005318	ENSUAMP00000002604	Autoimmune regulator.	CAF1C_H4-bd domain-containing protein.	0.732
AIRE	ENSUAMP00000017773	ENSUAMP00000005318	ENSUAMP00000017773	Autoimmune regulator.	CAF1C_H4-bd domain-containing protein.	0.732
AIRE	GATAD2A	ENSUAMP00000005318	ENSUAMP00000000667	Autoimmune regulator.	GATA zinc finger domain containing 2A.	0.744
AIRE	GATAD2B	ENSUAMP00000005318	ENSUAMP00000007652	Autoimmune regulator.	GATA zinc finger domain containing 2B.	0.744
AIRE	HDAC1	ENSUAMP00000005318	ENSUAMP00000017970	Autoimmune regulator.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.638
AIRE	HDAC2	ENSUAMP00000005318	ENSUAMP00000001578	Autoimmune regulator.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.638
AIRE	MBD3	ENSUAMP00000005318	ENSUAMP00000018561	Autoimmune regulator.	Methyl-CpG binding domain protein 3.	0.653
AIRE	MTA1	ENSUAMP00000005318	ENSUAMP00000012686	Autoimmune regulator.	Metastasis associated 1.	0.665
AIRE	MTA2	ENSUAMP00000005318	ENSUAMP00000035906	Autoimmune regulator.	Metastasis associated 1 family member 2.	0.665
AIRE	MTA3	ENSUAMP00000005318	ENSUAMP00000022386	Autoimmune regulator.	Metastasis associated 1 family member 3.	0.665
AIRE	RBBP7	ENSUAMP00000005318	ENSUAMP00000009562	Autoimmune regulator.	RB binding protein 7, chromatin remodeling factor.	0.732
ATN1	HDAC1	ENSUAMP00000035465	ENSUAMP00000017970	Atrophin 1.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.470
ATN1	HDAC2	ENSUAMP00000035465	ENSUAMP00000001578	Atrophin 1.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.470
CBX4	CBX6	ENSUAMP00000020995	ENSUAMP00000032021	Chromobox 4.	Chromobox 6.	0.785
CBX4	CBX7	ENSUAMP00000020995	ENSUAMP00000004874	Chromobox 4.	Chromobox 7.	0.624
CBX4	CBX8	ENSUAMP00000020995	ENSUAMP00000020993	Chromobox 4.	Chromobox 8.	0.978
CBX4	EED	ENSUAMP00000020995	ENSUAMP00000034278	Chromobox 4.	Embryonic ectoderm development.	0.829
CBX4	ENSUAMP00000000970	ENSUAMP00000020995	ENSUAMP00000000970	Chromobox 4.	Uncharacterized protein.	0.728
CBX4	ENSUAMP00000002604	ENSUAMP00000020995	ENSUAMP00000002604	Chromobox 4.	CAF1C_H4-bd domain-containing protein.	0.472
CBX4	ENSUAMP00000011054	ENSUAMP00000020995	ENSUAMP00000011054	Chromobox 4.	Uncharacterized protein.	0.795