STRINGSTRING
ENSUAMP00000001876 ENSUAMP00000001876 ENSUAMP00000016726 ENSUAMP00000016726 ENSUAMP00000017381 ENSUAMP00000017381 SLC10A1 SLC10A1 PMVK PMVK HSD3B7 HSD3B7 IDI1 IDI1 ENSUAMP00000018726 ENSUAMP00000018726 CYP39A1 CYP39A1 CYP2R1 CYP2R1 STARD3NL STARD3NL AKR1D1 AKR1D1 SERPINA6 SERPINA6 ENSUAMP00000020160 ENSUAMP00000020160 ENSUAMP00000020162 ENSUAMP00000020162 ENSUAMP00000020181 ENSUAMP00000020181 SCP2 SCP2 NSDHL NSDHL SLC10A2 SLC10A2 HSD11B1 HSD11B1 CYP24A1 CYP24A1 FDX1 FDX1 ENSUAMP00000021515 ENSUAMP00000021515 SLC51B SLC51B CYP8B1 CYP8B1 SRD5A3 SRD5A3 STARD4 STARD4 OSBPL9 OSBPL9 ENSUAMP00000024543 ENSUAMP00000024543 ENSUAMP00000024577 ENSUAMP00000024577 ABCB11 ABCB11 FAXDC2 FAXDC2 DHCR7 DHCR7 CDCP2 CDCP2 MVD MVD ENSUAMP00000026294 ENSUAMP00000026294 SCAP SCAP RUSC1 RUSC1 FDPS FDPS ENSUAMP00000026501 ENSUAMP00000026501 PTGIS PTGIS LBR LBR RXRA RXRA OSBPL6 OSBPL6 TM7SF2 TM7SF2 SRD5A2 SRD5A2 OSBPL1A OSBPL1A DHCR24 DHCR24 SREBF1 SREBF1 ENSUAMP00000013226 ENSUAMP00000013226 CYP46A1 CYP46A1 HSD17B14 HSD17B14 FADS6 FADS6 FDXR FDXR ENSUAMP00000012923 ENSUAMP00000012923 ACOT8 ACOT8 HMGCR HMGCR ENSUAMP00000012268 ENSUAMP00000012268 OSBP OSBP GGPS1 GGPS1 POMC POMC CYP27C1 CYP27C1 EBPL EBPL ABCC3 ABCC3 STARD3 STARD3 PLPP6 PLPP6 HMGCS1 HMGCS1 SQLE SQLE PLPP7 PLPP7 SLCO1A2 SLCO1A2 TSPO TSPO FDFT1 FDFT1 ENSUAMP00000008973 ENSUAMP00000008973 HSD17B1 HSD17B1 NCOA1 NCOA1 AKR1C8P AKR1C8P AKR1E2 AKR1E2 ENSUAMP00000008515 ENSUAMP00000008515 CH25H CH25H RAN RAN ADGRD1 ADGRD1 SREBF2 SREBF2 CYP7B1 CYP7B1 ENSUAMP00000007027 ENSUAMP00000007027 ENSUAMP00000007016 ENSUAMP00000007016 MTF1 MTF1 INSIG2 INSIG2 HSDL2 HSDL2 MBTPS1 MBTPS1 HSDL1 HSDL1 ENSUAMP00000027762 ENSUAMP00000027762 CYP27A1 CYP27A1 ENSUAMP00000027938 ENSUAMP00000027938 GC GC ENSUAMP00000028186 ENSUAMP00000028186 CYP21A2 CYP21A2 DHRS7C DHRS7C CCDC160 CCDC160 SLC27A2 SLC27A2 CYP11A1 CYP11A1 SRD5A1 SRD5A1 OSBPL3 OSBPL3 ENSUAMP00000032699 ENSUAMP00000032699 KPNB1 KPNB1 STARD5 STARD5 CYP51A1 CYP51A1 SDR42E1 SDR42E1 HSD17B2 HSD17B2 HSD17B13 HSD17B13 HSD17B11 HSD17B11 SC5D SC5D NFYB NFYB ENSUAMP00000034832 ENSUAMP00000034832 MBTPS2 MBTPS2 ENSUAMP00000035001 ENSUAMP00000035001 CYP17A1 CYP17A1 VDR VDR NCOA2 NCOA2 ACOX2 ACOX2 CGA CGA NR1H4 NR1H4 ENSUAMP00000036524 ENSUAMP00000036524 TSPO2 TSPO2 MVK MVK SLC51A SLC51A CYP27B1 CYP27B1 ENSUAMP00000005903 ENSUAMP00000005903 TSPOAP1 TSPOAP1 NFYC NFYC AKR1B1 AKR1B1 ENSUAMP00000004668 ENSUAMP00000004668 ENSUAMP00000004665 ENSUAMP00000004665 ENSUAMP00000004492 ENSUAMP00000004492 STAR STAR SCP2D1 SCP2D1 LSS LSS ENSUAMP00000003092 ENSUAMP00000003092 OSBPL7 OSBPL7 ENSUAMP00000002886 ENSUAMP00000002886 AMACR AMACR OSBP2 OSBP2 CYP19A1 CYP19A1 ENSUAMP00000001923 ENSUAMP00000001923
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000001876Uncharacterized protein. (2013 aa)
ENSUAMP00000016726EXPERA domain-containing protein. (230 aa)
ENSUAMP00000017381Uncharacterized protein. (128 aa)
SLC10A1Solute carrier family 10 member 1. (349 aa)
PMVKPhosphomevalonate kinase. (192 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (369 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (227 aa)
ENSUAMP00000018726Uncharacterized protein. (386 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
STARD3NLSTARD3 N-terminal like. (132 aa)
AKR1D1Aldo-keto reductase family 1 member D1. (323 aa)
SERPINA6Serpin family A member 6; Belongs to the serpin family. (405 aa)
ENSUAMP00000020160Uncharacterized protein. (375 aa)
ENSUAMP00000020162Uncharacterized protein. (830 aa)
ENSUAMP00000020181Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (171 aa)
SCP2Sterol carrier protein 2. (457 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
SLC10A2Solute carrier family 10 member 2. (346 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
FDX1Ferredoxin 1. (124 aa)
ENSUAMP00000021515Solute carrier organic anion transporter family member. (689 aa)
SLC51BSolute carrier family 51 beta subunit. (133 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
SRD5A3Steroid 5 alpha-reductase 3. (318 aa)
STARD4StAR related lipid transfer domain containing 4. (208 aa)
OSBPL9Oxysterol-binding protein; Belongs to the OSBP family. (660 aa)
ENSUAMP00000024543Uncharacterized protein. (554 aa)
ENSUAMP00000024577Uncharacterized protein. (146 aa)
ABCB11ATP binding cassette subfamily B member 11. (1319 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (333 aa)
DHCR77-dehydrocholesterol reductase. (586 aa)
CDCP2CUB domain containing protein 2. (411 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
ENSUAMP000000262942Fe-2S ferredoxin-type domain-containing protein. (253 aa)
SCAPSREBF chaperone. (1229 aa)
RUSC1RUN and SH3 domain containing 1. (891 aa)
FDPSFarnesyl diphosphate synthase. (248 aa)
ENSUAMP00000026501Uncharacterized protein. (141 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa)
LBRLamin B receptor. (624 aa)
RXRARetinoid X receptor alpha. (469 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (954 aa)
TM7SF2Transmembrane 7 superfamily member 2. (418 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (856 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
ENSUAMP00000013226Cys_knot domain-containing protein. (140 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (506 aa)
HSD17B14Hydroxysteroid 17-beta dehydrogenase 14. (336 aa)
FADS6Fatty acid desaturase 6. (340 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (492 aa)
ENSUAMP00000012923Uncharacterized protein. (1655 aa)
ACOT8Acyl-CoA thioesterase 8. (317 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (897 aa)
ENSUAMP00000012268Uncharacterized protein. (76 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (793 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
POMCProopiomelanocortin. (223 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
EBPLEBP like. (193 aa)
ABCC3ATP binding cassette subfamily C member 3. (1680 aa)
STARD3StAR related lipid transfer domain containing 3. (445 aa)
PLPP6Phospholipid phosphatase 6. (291 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
SQLESqualene epoxidase. (340 aa)
PLPP7Phospholipid phosphatase 7 (inactive). (271 aa)
SLCO1A2Solute carrier organic anion transporter family member. (407 aa)
TSPOTranslocator protein. (169 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (460 aa)
ENSUAMP00000008973FABP domain-containing protein. (128 aa)
HSD17B1Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
AKR1C8PAldo-keto reductase family 1 member C8, pseudogene. (324 aa)
AKR1E2Aldo-keto reductase family 1 member E2. (301 aa)
ENSUAMP00000008515Uncharacterized protein. (148 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (270 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (279 aa)
ADGRD1Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family. (868 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1117 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (485 aa)
ENSUAMP00000007027Uncharacterized protein. (81 aa)
ENSUAMP00000007016Uncharacterized protein. (241 aa)
MTF1Metal regulatory transcription factor 1. (745 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
HSDL2Hydroxysteroid dehydrogenase like 2. (390 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1052 aa)
HSDL1Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa)
ENSUAMP00000027762Uncharacterized protein. (188 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (441 aa)
ENSUAMP00000027938Uncharacterized protein. (110 aa)
GCGC vitamin D binding protein. (435 aa)
ENSUAMP00000028186Uncharacterized protein. (505 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
CCDC160Coiled-coil domain containing 160. (323 aa)
SLC27A2Solute carrier family 27 member 2. (385 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
OSBPL3Oxysterol-binding protein; Belongs to the OSBP family. (891 aa)
ENSUAMP000000326993Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
KPNB1Karyopherin subunit beta 1. (877 aa)
STARD5StAR related lipid transfer domain containing 5. (213 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
SDR42E1Short chain dehydrogenase/reductase family 42E, member 1; Belongs to the 3-beta-HSD family. (393 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (380 aa)
HSD17B13Hydroxysteroid 17-beta dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
HSD17B11Hydroxysteroid 17-beta dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
NFYBNuclear transcription factor Y subunit beta. (216 aa)
ENSUAMP00000034832PH domain-containing protein. (61 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (530 aa)
ENSUAMP00000035001Uncharacterized protein. (321 aa)
CYP17A1Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (356 aa)
VDRVitamin D receptor. (427 aa)
NCOA2Nuclear receptor coactivator 2. (945 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (482 aa)
ENSUAMP00000036524Uncharacterized protein. (347 aa)
TSPO2Translocator protein 2. (174 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
SLC51ASolute carrier family 51 alpha subunit. (341 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
ENSUAMP00000005903Uncharacterized protein. (56 aa)
TSPOAP1TSPO associated protein 1. (1846 aa)
NFYCNuclear transcription factor Y subunit gamma. (335 aa)
AKR1B1Aldo-keto reductase family 1 member B. (285 aa)
ENSUAMP00000004668Uncharacterized protein. (95 aa)
ENSUAMP00000004665AMP-binding domain-containing protein. (629 aa)
ENSUAMP00000004492Uncharacterized protein. (154 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
SCP2D1SCP2 sterol binding domain containing 1. (156 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (733 aa)
ENSUAMP00000003092Aldo_ket_red domain-containing protein. (163 aa)
OSBPL7Oxysterol binding protein like 7. (941 aa)
ENSUAMP00000002886Uncharacterized protein. (479 aa)
AMACRAlpha-methylacyl-CoA racemase. (248 aa)
OSBP2Oxysterol-binding protein; Belongs to the OSBP family. (744 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (465 aa)
ENSUAMP00000001923FABP domain-containing protein. (128 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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