STRINGSTRING
ENSUAMP00000004341 ENSUAMP00000004341 POLR2H POLR2H KAT2B KAT2B H2BC1 H2BC1 ZC3H12B ZC3H12B ENSUAMP00000006129 ENSUAMP00000006129 ESR1 ESR1 ENSUAMP00000006306 ENSUAMP00000006306 ENSUAMP00000006323 ENSUAMP00000006323 ENSUAMP00000006335 ENSUAMP00000006335 ENSUAMP00000006561 ENSUAMP00000006561 GTF2A2 GTF2A2 ZC3H12C ZC3H12C ENSUAMP00000007225 ENSUAMP00000007225 CARM1 CARM1 TNRC6B TNRC6B NCOA1 NCOA1 PRMT1 PRMT1 ENSUAMP00000009736 ENSUAMP00000009736 POLR2E POLR2E ENSUAMP00000011956 ENSUAMP00000011956 ENSUAMP00000012333 ENSUAMP00000012333 GREB1 GREB1 SP1 SP1 POLR2J POLR2J ENSUAMP00000014088 ENSUAMP00000014088 ENSUAMP00000014212 ENSUAMP00000014212 ENSUAMP00000014224 ENSUAMP00000014224 ENSUAMP00000014243 ENSUAMP00000014243 ENSUAMP00000014260 ENSUAMP00000014260 ENSUAMP00000014262 ENSUAMP00000014262 ENSUAMP00000014264 ENSUAMP00000014264 ENSUAMP00000014288 ENSUAMP00000014288 FOXA1 FOXA1 ENSUAMP00000015277 ENSUAMP00000015277 ENSUAMP00000016793 ENSUAMP00000016793 H2AZ2 H2AZ2 ENSUAMP00000017069 ENSUAMP00000017069 HIST3H2BB HIST3H2BB KANK2 KANK2 ZC3H12A ZC3H12A POLR2C POLR2C HDAC1 HDAC1 H2AX H2AX KDM4B KDM4B POLR2A POLR2A USF2 USF2 ENSUAMP00000019851 ENSUAMP00000019851 NRIP1 NRIP1 ENSUAMP00000020754 ENSUAMP00000020754 ENSUAMP00000020755 ENSUAMP00000020755 ENSUAMP00000020808 ENSUAMP00000020808 ENSUAMP00000020825 ENSUAMP00000020825 ENSUAMP00000020853 ENSUAMP00000020853 GTF2A1 GTF2A1 ENSUAMP00000022270 ENSUAMP00000022270 CITED1 CITED1 HSP90AA1 HSP90AA1 TBPL1 TBPL1 NCOA3 NCOA3 GTF2F2 GTF2F2 H3-3A H3-3A FOSB FOSB TRPS1 TRPS1 POLR2F POLR2F POLR2I POLR2I KANK4 KANK4 KAT5 KAT5 PRMT8 PRMT8 PTGES3 PTGES3 KANK1 KANK1 ENSUAMP00000028455 ENSUAMP00000028455 GATA3 GATA3 KANK3 KANK3 H2BC21 H2BC21 ENSUAMP00000029193 ENSUAMP00000029193 ENSUAMP00000029195 ENSUAMP00000029195 ENSUAMP00000029196 ENSUAMP00000029196 H2BE1 H2BE1 CDK9 CDK9 GREB1L GREB1L ENSUAMP00000029966 ENSUAMP00000029966 DDX5 DDX5 CREBBP CREBBP ENSUAMP00000031302 ENSUAMP00000031302 POLR2D POLR2D EP300 EP300 ENSUAMP00000032400 ENSUAMP00000032400 C11orf88 C11orf88 TFF3 TFF3 USF1 USF1 H2BC11 H2BC11 ENSUAMP00000033915 ENSUAMP00000033915 ENSUAMP00000033918 ENSUAMP00000033918 ENSUAMP00000033919 ENSUAMP00000033919 ENSUAMP00000033939 ENSUAMP00000033939 ENSUAMP00000033945 ENSUAMP00000033945 ENSUAMP00000033949 ENSUAMP00000033949 ENSUAMP00000033950 ENSUAMP00000033950 MED1 MED1 POLR2G POLR2G GTF2F1 GTF2F1 CXXC5 CXXC5 ENSUAMP00000035159 ENSUAMP00000035159 NCOA2 NCOA2 ENSUAMP00000035454 ENSUAMP00000035454 CHD1 CHD1 CCNT1 CCNT1 ENSUAMP00000036676 ENSUAMP00000036676 H2AZ1 H2AZ1 H3F3B H3F3B TBP TBP ENSUAMP00000003633 ENSUAMP00000003633 ENSUAMP00000003566 ENSUAMP00000003566 ENSUAMP00000003527 ENSUAMP00000003527 ENSUAMP00000003497 ENSUAMP00000003497 ENSUAMP00000002618 ENSUAMP00000002618 TBPL2 TBPL2 MYB MYB PGR PGR ENSUAMP00000000641 ENSUAMP00000000641 ENSUAMP00000000300 ENSUAMP00000000300 ENSUAMP00000000293 ENSUAMP00000000293
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000004341annotation not available (103 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
KAT2BLysine acetyltransferase 2B. (629 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ZC3H12BZinc finger CCCH-type containing 12B. (836 aa)
ENSUAMP00000006129Histone domain-containing protein. (199 aa)
ESR1Estrogen receptor 1. (490 aa)
ENSUAMP00000006306annotation not available (103 aa)
ENSUAMP00000006323Histone H3; Belongs to the histone H3 family. (136 aa)
ENSUAMP00000006335Histone H2B; Belongs to the histone H2B family. (135 aa)
ENSUAMP00000006561Histone H2B; Belongs to the histone H2B family. (126 aa)
GTF2A2General transcription factor IIA subunit 2. (71 aa)
ZC3H12CZinc finger CCCH-type containing 12C. (901 aa)
ENSUAMP00000007225Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (636 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1802 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (353 aa)
ENSUAMP00000009736Uncharacterized protein. (71 aa)
POLR2ERNA polymerase II subunit E. (294 aa)
ENSUAMP00000011956Uncharacterized protein. (119 aa)
ENSUAMP00000012333Uncharacterized protein. (186 aa)
GREB1Uncharacterized protein. (1953 aa)
SP1Sp1 transcription factor. (780 aa)
POLR2JRNA polymerase II subunit J. (117 aa)
ENSUAMP00000014088Uncharacterized protein. (242 aa)
ENSUAMP00000014212annotation not available (126 aa)
ENSUAMP00000014224annotation not available (103 aa)
ENSUAMP00000014243Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSUAMP00000014260annotation not available (103 aa)
ENSUAMP00000014262Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
ENSUAMP00000014264annotation not available (136 aa)
ENSUAMP00000014288Histone H2B; Belongs to the histone H2B family. (126 aa)
FOXA1Forkhead box A1. (472 aa)
ENSUAMP00000015277Uncharacterized protein. (74 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (134 aa)
ENSUAMP00000017069Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST3H2BBHistone H2B; Belongs to the histone H2B family. (126 aa)
KANK2KN motif and ankyrin repeat domains 2. (886 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
KDM4BLysine demethylase 4B. (797 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1837 aa)
USF2Upstream transcription factor 2, c-fos interacting. (335 aa)
ENSUAMP00000019851Uncharacterized protein. (82 aa)
NRIP1Nuclear receptor interacting protein 1. (1156 aa)
ENSUAMP00000020754Uncharacterized protein. (105 aa)
ENSUAMP00000020755Uncharacterized protein. (193 aa)
ENSUAMP00000020808annotation not available (126 aa)
ENSUAMP00000020825annotation not available (103 aa)
ENSUAMP00000020853Histone domain-containing protein. (178 aa)
GTF2A1General transcription factor IIA subunit 1. (371 aa)
ENSUAMP00000022270Histone H2B; Belongs to the histone H2B family. (127 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
NCOA3Nuclear receptor coactivator. (1431 aa)
GTF2F2General transcription factor IIF subunit 2. (241 aa)
H3-3AHistone domain-containing protein. (142 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
TRPS1Transcriptional repressor GATA binding 1. (1281 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
KANK4KN motif and ankyrin repeat domains 4. (999 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
PTGES3Prostaglandin E synthase 3. (180 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
ENSUAMP00000028455Uncharacterized protein. (71 aa)
GATA3GATA binding protein 3. (444 aa)
KANK3KN motif and ankyrin repeat domains 3. (816 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSUAMP00000029193annotation not available (126 aa)
ENSUAMP00000029195annotation not available (103 aa)
ENSUAMP00000029196Histone H3; Belongs to the histone H3 family. (136 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1923 aa)
ENSUAMP00000029966annotation not available (113 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
CREBBPCREB binding protein. (2333 aa)
ENSUAMP00000031302Histone domain-containing protein; Belongs to the histone H2B family. (170 aa)
POLR2DRNA polymerase II subunit D. (132 aa)
EP300E1A binding protein p300. (2399 aa)
ENSUAMP00000032400Uncharacterized protein. (67 aa)
C11orf88Chromosome 11 open reading frame 88. (155 aa)
TFF3Trefoil factor 3. (80 aa)
USF1Upstream transcription factor 1. (373 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSUAMP00000033915Histone domain-containing protein. (125 aa)
ENSUAMP00000033918annotation not available (103 aa)
ENSUAMP00000033919Histone domain-containing protein; Belongs to the histone H2B family. (128 aa)
ENSUAMP00000033939Histone H2B; Belongs to the histone H2B family. (132 aa)
ENSUAMP00000033945Histone H3; Belongs to the histone H3 family. (93 aa)
ENSUAMP00000033949annotation not available (126 aa)
ENSUAMP00000033950annotation not available (103 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
POLR2GRNA polymerase II subunit G. (241 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (538 aa)
CXXC5CXXC finger protein 5. (318 aa)
ENSUAMP00000035159Uncharacterized protein. (321 aa)
NCOA2Nuclear receptor coactivator 2. (945 aa)
ENSUAMP00000035454CXXC-type domain-containing protein. (656 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1772 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (726 aa)
ENSUAMP00000036676JmjN domain-containing protein. (161 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (159 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
TBPTATA-box binding protein. (324 aa)
ENSUAMP00000003633Uncharacterized protein. (444 aa)
ENSUAMP00000003566Uncharacterized protein; Belongs to the RNA polymerase beta chain family. (942 aa)
ENSUAMP00000003527Uncharacterized protein. (72 aa)
ENSUAMP00000003497Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSUAMP00000002618Histone H2A; Belongs to the histone H2A family. (113 aa)
TBPL2TATA-box binding protein like 2. (344 aa)
MYBMYB proto-oncogene, transcription factor. (727 aa)
PGRProgesterone receptor. (634 aa)
ENSUAMP00000000641Uncharacterized protein. (139 aa)
ENSUAMP00000000300Bromo domain-containing protein. (84 aa)
ENSUAMP00000000293Histone H2B; Belongs to the histone H2B family. (67 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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