36 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFYB	Nuclear transcription factor Y subunit beta. (216 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (343 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
	EP300	E1A binding protein p300. (2399 aa)
	ENSUAMP00000031091	Uncharacterized protein. (151 aa)
	MSTN	Myostatin. (376 aa)
	CREBBP	CREB binding protein. (2333 aa)
	ENSUAMP00000030435	Fork-head domain-containing protein. (196 aa)
	FOXO4	Forkhead box O4. (506 aa)
	BCL6B	BCL6B transcription repressor. (461 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (761 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa)
	SIRT1	Sirtuin 1. (618 aa)
	AGRP	Agouti related neuropeptide. (131 aa)
	GDF11	Growth differentiation factor 11. (409 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (374 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	BTG1	BTG anti-proliferation factor 1. (155 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
	FOXO3B	Forkhead box O3B. (244 aa)
	FOXO3	Forkhead box O3. (453 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ENSUAMP00000036524	Uncharacterized protein. (347 aa)
	ENSUAMP00000035001	Uncharacterized protein. (321 aa)
	AKT1	Non-specific serine/threonine protein kinase. (572 aa)
	ENSUAMP00000008994	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (100 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (335 aa)
	KAT2B	Lysine acetyltransferase 2B. (629 aa)
	FOXO1	Forkhead box O1. (660 aa)
	ENSUAMP00000000300	Bromo domain-containing protein. (84 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	FOXO1	ENSUAMP00000020167	ENSUAMP00000004446	Agouti related neuropeptide.	Forkhead box O1.	0.604
AKT1	AKT2	ENSUAMP00000010674	ENSUAMP00000037592	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT1	AKT3	ENSUAMP00000010674	ENSUAMP00000011671	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT1	ENSUAMP00000030435	ENSUAMP00000010674	ENSUAMP00000030435	Non-specific serine/threonine protein kinase.	Fork-head domain-containing protein.	0.923
AKT1	FOXO1	ENSUAMP00000010674	ENSUAMP00000004446	Non-specific serine/threonine protein kinase.	Forkhead box O1.	0.954
AKT1	FOXO3	ENSUAMP00000010674	ENSUAMP00000012151	Non-specific serine/threonine protein kinase.	Forkhead box O3.	0.943
AKT1	FOXO3B	ENSUAMP00000010674	ENSUAMP00000012153	Non-specific serine/threonine protein kinase.	Forkhead box O3B.	0.911
AKT1	FOXO4	ENSUAMP00000010674	ENSUAMP00000029815	Non-specific serine/threonine protein kinase.	Forkhead box O4.	0.923
AKT1	SMAD4	ENSUAMP00000010674	ENSUAMP00000018392	Non-specific serine/threonine protein kinase.	Mothers against decapentaplegic homolog.	0.437
AKT2	AKT1	ENSUAMP00000037592	ENSUAMP00000010674	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.875
AKT2	AKT3	ENSUAMP00000037592	ENSUAMP00000011671	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT2	ENSUAMP00000030435	ENSUAMP00000037592	ENSUAMP00000030435	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.923
AKT2	FOXO1	ENSUAMP00000037592	ENSUAMP00000004446	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.945
AKT2	FOXO3	ENSUAMP00000037592	ENSUAMP00000012151	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.943
AKT2	FOXO3B	ENSUAMP00000037592	ENSUAMP00000012153	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3B.	0.911
AKT2	FOXO4	ENSUAMP00000037592	ENSUAMP00000029815	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O4.	0.923
AKT2	SMAD4	ENSUAMP00000037592	ENSUAMP00000018392	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.437
AKT3	AKT1	ENSUAMP00000011671	ENSUAMP00000010674	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.875
AKT3	AKT2	ENSUAMP00000011671	ENSUAMP00000037592	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.875
AKT3	ENSUAMP00000030435	ENSUAMP00000011671	ENSUAMP00000030435	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.940