STRINGSTRING
ATF2 ATF2 ENSUAMP00000009614 ENSUAMP00000009614 MAPK8 MAPK8 JUN JUN ENSUAMP00000008648 ENSUAMP00000008648 KHNYN KHNYN LRRC14 LRRC14 CASP8 CASP8 TONSL TONSL APP APP ENSUAMP00000006607 ENSUAMP00000006607 ENSUAMP00000006398 ENSUAMP00000006398 ENSUAMP00000006374 ENSUAMP00000006374 ENSUAMP00000006300 ENSUAMP00000006300 FNBP4 FNBP4 NFKB2 NFKB2 ENSUAMP00000003950 ENSUAMP00000003950 PPP4R1 PPP4R1 TAB2 TAB2 TRAF2 TRAF2 ENSUAMP00000001501 ENSUAMP00000001501 MAPKAPK2 MAPKAPK2 ECSIT ECSIT NOD1 NOD1 USP14 USP14 UBE2V1 UBE2V1 TAB1 TAB1 VRK3 VRK3 CHUK CHUK ENSUAMP00000036602 ENSUAMP00000036602 ALPK1 ALPK1 ENSUAMP00000036314 ENSUAMP00000036314 N4BP1 N4BP1 ENSUAMP00000034960 ENSUAMP00000034960 FOSL2 FOSL2 NLRP13 NLRP13 ENSUAMP00000033902 ENSUAMP00000033902 ENSUAMP00000033331 ENSUAMP00000033331 MAP2K4 MAP2K4 ENSUAMP00000032535 ENSUAMP00000032535 ENSUAMP00000032533 ENSUAMP00000032533 ENSUAMP00000032511 ENSUAMP00000032511 IRAK2 IRAK2 MAPK14 MAPK14 NKIRAS2 NKIRAS2 LRRC45 LRRC45 MAP3K7 MAP3K7 MAPK3 MAPK3 ENSUAMP00000031438 ENSUAMP00000031438 PELI2 PELI2 NFKBIA NFKBIA RPS6KA3 RPS6KA3 RPS6KA4 RPS6KA4 TRAF6 TRAF6 MAP3K1 MAP3K1 MAPK9 MAPK9 MAP2K7 MAP2K7 ELK1 ELK1 ENSUAMP00000027615 ENSUAMP00000027615 PPP2CB PPP2CB TAB3 TAB3 TMEM189-UBE2V1 TMEM189-UBE2V1 DUSP7 DUSP7 MAP2K6 MAP2K6 RELA RELA CREB5 CREB5 ENSUAMP00000026449 ENSUAMP00000026449 PELI1 PELI1 ENSUAMP00000025678 ENSUAMP00000025678 NLRP9 NLRP9 RELCH RELCH ENSUAMP00000025192 ENSUAMP00000025192 IRAK1 IRAK1 LRRC34 LRRC34 ENSUAMP00000024093 ENSUAMP00000024093 CREB1 CREB1 RIPK2 RIPK2 PPP2CA PPP2CA ENSUAMP00000023088 ENSUAMP00000023088 ENSUAMP00000022960 ENSUAMP00000022960 MAPK10 MAPK10 S100B S100B NLRC5 NLRC5 PPP2R5D PPP2R5D ENSUAMP00000021443 ENSUAMP00000021443 NFKB1 NFKB1 ENSUAMP00000020715 ENSUAMP00000020715 AGER AGER KXD1 KXD1 IKBKB IKBKB MAP2K3 MAP2K3 PPP4R4 PPP4R4 NKIRAS1 NKIRAS1 PELI3 PELI3 TICAM1 TICAM1 NLRX1 NLRX1 RPS6KA5 RPS6KA5 MAPKAPK3 MAPKAPK3 DUSP6 DUSP6 LRRC71 LRRC71 MAPK11 MAPK11 ENSUAMP00000016793 ENSUAMP00000016793 ENSUAMP00000016646 ENSUAMP00000016646 DUSP4 DUSP4 ATF1 ATF1 MAPK15 MAPK15 VWC2 VWC2 ENSUAMP00000015662 ENSUAMP00000015662 RPS6KA1 RPS6KA1 ENSUAMP00000014686 ENSUAMP00000014686 IKBKG IKBKG NFKBIB NFKBIB MAPK1 MAPK1 PPP2R1A PPP2R1A RPS6KA2 RPS6KA2 ENSUAMP00000011014 ENSUAMP00000011014 ENSUAMP00000010232 ENSUAMP00000010232
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSUAMP00000009614WRNPLPNID domain-containing protein. (950 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
ENSUAMP00000008648Uncharacterized protein. (113 aa)
KHNYNKH and NYN domain containing. (668 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
TONSLTonsoku like, DNA repair protein. (1345 aa)
APPAmyloid beta precursor protein. (735 aa)
ENSUAMP00000006607Uncharacterized protein. (215 aa)
ENSUAMP00000006398annotation not available (356 aa)
ENSUAMP00000006374Uncharacterized protein. (178 aa)
ENSUAMP00000006300Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
FNBP4Formin binding protein 4. (1018 aa)
NFKB2Nuclear factor kappa B subunit 2. (581 aa)
ENSUAMP00000003950EF-hand domain-containing protein; Belongs to the S-100 family. (145 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (937 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (683 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
ENSUAMP00000001501Uncharacterized protein. (470 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (387 aa)
ECSITECSIT signalling integrator. (433 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (874 aa)
USP14Ubiquitin specific peptidase 14; Belongs to the peptidase C19 family. (350 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (156 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
VRK3VRK serine/threonine kinase 3. (483 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSUAMP00000036602Uncharacterized protein. (82 aa)
ALPK1Alpha kinase 1. (1239 aa)
ENSUAMP00000036314Protein kinase domain-containing protein. (321 aa)
N4BP1NEDD4 binding protein 1. (724 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
NLRP13NLR family pyrin domain containing 13. (1030 aa)
ENSUAMP00000033902USP domain-containing protein; Belongs to the peptidase C19 family. (284 aa)
ENSUAMP00000033331UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
ENSUAMP00000032535Uncharacterized protein. (145 aa)
ENSUAMP00000032533Uncharacterized protein. (127 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031438Protein kinase domain-containing protein. (456 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (417 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
RPS6KA3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ELK1ETS transcription factor ELK1. (435 aa)
ENSUAMP00000027615Uncharacterized protein. (150 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
TMEM189-UBE2V1TMEM189-UBE2V1 readthrough. (247 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
ENSUAMP00000026449Uncharacterized protein. (121 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ENSUAMP00000025678Uncharacterized protein. (163 aa)
NLRP9NLR family pyrin domain containing 9. (983 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (777 aa)
ENSUAMP00000025192Ubiquitin-like domain-containing protein. (156 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (664 aa)
LRRC34Leucine rich repeat containing 34. (402 aa)
ENSUAMP00000024093G protein gamma domain-containing protein. (201 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ENSUAMP00000023088Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (208 aa)
ENSUAMP00000022960Uncharacterized protein. (70 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
NLRC5NLR family CARD domain containing 5. (1745 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (601 aa)
ENSUAMP00000021443Ubiquitin-like domain-containing protein. (77 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ENSUAMP00000020715Ubiquitin-like domain-containing protein. (132 aa)
AGERAdvanced glycosylation end-product specific receptor. (410 aa)
KXD1KxDL motif containing 1. (128 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (751 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
NLRX1NLR family member X1. (975 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LRRC71Leucine rich repeat containing 71. (567 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
ENSUAMP00000016646Uncharacterized protein. (167 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
ATF1Activating transcription factor 1. (270 aa)
MAPK15Mitogen-activated protein kinase. (680 aa)
VWC2Von Willebrand factor C domain containing 2. (303 aa)
ENSUAMP00000015662UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
RPS6KA1Ribosomal protein S6 kinase. (836 aa)
ENSUAMP00000014686Uncharacterized protein. (238 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
RPS6KA2Ribosomal protein S6 kinase. (753 aa)
ENSUAMP00000011014Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (474 aa)
ENSUAMP00000010232Ubiquitin-like domain-containing protein. (88 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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