STRINGSTRING
ENSUAMP00000003451 ENSUAMP00000003451 PSMB1 PSMB1 ENSUAMP00000004531 ENSUAMP00000004531 ATF4 ATF4 ENSUAMP00000005735 ENSUAMP00000005735 FBXL17 FBXL17 PSME4 PSME4 PRDX1 PRDX1 ENSUAMP00000010232 ENSUAMP00000010232 PSMB6 PSMB6 PSMB3 PSMB3 PSMB11 PSMB11 TRIM21 TRIM21 PSMD7 PSMD7 PSMD13 PSMD13 PSME3 PSME3 UBXN7 UBXN7 ENSUAMP00000015657 ENSUAMP00000015657 CUL3 CUL3 ENSUAMP00000015215 ENSUAMP00000015215 MUL1 MUL1 ENSUAMP00000012220 ENSUAMP00000012220 GSK3B GSK3B AKT3 AKT3 ENSUAMP00000000292 ENSUAMP00000000292 SESN1 SESN1 PSMB2 PSMB2 PSMC4 PSMC4 PSMB5 PSMB5 PSMF1 PSMF1 PSMD9 PSMD9 AKT2 AKT2 ENSUAMP00000037175 ENSUAMP00000037175 PSMD12 PSMD12 ENSUAMP00000036637 ENSUAMP00000036637 PSMD4 PSMD4 SQSTM1 SQSTM1 ENSUAMP00000035546 ENSUAMP00000035546 SRXN1 SRXN1 PSMA2 PSMA2 NFE2L3 NFE2L3 PSMB8 PSMB8 PSMB9 PSMB9 PSMD8 PSMD8 DPP3 DPP3 PSMD3 PSMD3 PSMD10 PSMD10 KXD1 KXD1 ENSUAMP00000020715 ENSUAMP00000020715 PSMD5 PSMD5 NPLOC4 NPLOC4 ENSUAMP00000021443 ENSUAMP00000021443 NFE2L1 NFE2L1 ENSUAMP00000022022 ENSUAMP00000022022 PSMA4 PSMA4 MAFK MAFK KEAP1 KEAP1 PSMB4 PSMB4 PSMC2 PSMC2 ENSUAMP00000025192 ENSUAMP00000025192 PSMA1 PSMA1 SKP2 SKP2 ENSUAMP00000026056 ENSUAMP00000026056 PSMB10 PSMB10 ENSUAMP00000026844 ENSUAMP00000026844 MAP1LC3A MAP1LC3A ENSUAMP00000027679 ENSUAMP00000027679 ENSUAMP00000028182 ENSUAMP00000028182 CUL1 CUL1 SPATA5 SPATA5 PSMB7 PSMB7 ENSUAMP00000033514 ENSUAMP00000033514 PSMA7 PSMA7 KIAA2012 KIAA2012 SESN2 SESN2 SPATA5L1 SPATA5L1 EP300 EP300 SKP1 SKP1 ENSUAMP00000007910 ENSUAMP00000007910 MTFP1 MTFP1 NFE2L2 NFE2L2 PSMC5 PSMC5 UFD1 UFD1 PSMA3 PSMA3 PSMC3 PSMC3 PSMC6 PSMC6 PSMA6 PSMA6 CREBBP CREBBP RBX1 RBX1 PSME1 PSME1 PSME2 PSME2 BTRC BTRC VCP VCP AKT1 AKT1 BACH1 BACH1 PSMD1 PSMD1 PSMD2 PSMD2 PSMD11 PSMD11 TRIM58 TRIM58 ENSUAMP00000003372 ENSUAMP00000003372
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000003451GSAP-16 domain-containing protein. (175 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSUAMP00000004531AAA domain-containing protein; Belongs to the AAA ATPase family. (421 aa)
ATF4Activating transcription factor 4. (351 aa)
ENSUAMP00000005735PROTEASOME_ALPHA_1 domain-containing protein. (80 aa)
FBXL17F-box and leucine rich repeat protein 17. (662 aa)
PSME4Proteasome activator subunit 4. (1436 aa)
PRDX1Peroxiredoxin 1. (185 aa)
ENSUAMP00000010232Ubiquitin-like domain-containing protein. (88 aa)
PSMB6Proteasome subunit beta. (219 aa)
PSMB3Proteasome subunit beta. (202 aa)
PSMB11Proteasome subunit beta. (292 aa)
TRIM21Tripartite motif containing 21. (469 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PSME3Proteasome activator subunit 3. (254 aa)
UBXN7UBX domain protein 7. (520 aa)
ENSUAMP00000015657BZIP domain-containing protein. (813 aa)
CUL3Cullin 3; Belongs to the cullin family. (766 aa)
ENSUAMP00000015215Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
ENSUAMP00000012220ATPase_AAA_core domain-containing protein. (174 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000000292PCI domain-containing protein. (389 aa)
SESN1Sestrin 1. (492 aa)
PSMB2Proteasome subunit beta. (167 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (400 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMD9PDZ domain-containing protein. (309 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037175MPN domain-containing protein. (156 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ENSUAMP00000036637PCI domain-containing protein. (405 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (344 aa)
SQSTM1Sequestosome 1. (491 aa)
ENSUAMP00000035546Uncharacterized protein. (70 aa)
SRXN1Sulfiredoxin. (137 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
NFE2L3Nuclear factor, erythroid 2 like 3. (690 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB9Proteasome subunit beta. (220 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
DPP3Dipeptidyl peptidase 3; Belongs to the peptidase M49 family. (757 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (151 aa)
KXD1KxDL motif containing 1. (128 aa)
ENSUAMP00000020715Ubiquitin-like domain-containing protein. (132 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (592 aa)
ENSUAMP00000021443Ubiquitin-like domain-containing protein. (77 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (798 aa)
ENSUAMP00000022022Uncharacterized protein. (107 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
MAFKMAF bZIP transcription factor K. (156 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
ENSUAMP00000025192Ubiquitin-like domain-containing protein. (156 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
ENSUAMP00000026056MitMem_reg domain-containing protein. (95 aa)
PSMB10Proteasome subunit beta 10. (327 aa)
ENSUAMP00000026844BACK domain-containing protein. (259 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (105 aa)
ENSUAMP00000027679Uncharacterized protein. (51 aa)
ENSUAMP00000028182Uncharacterized protein. (128 aa)
CUL1Cullin 1; Belongs to the cullin family. (742 aa)
SPATA5Spermatogenesis associated 5. (756 aa)
PSMB7Proteasome subunit beta. (277 aa)
ENSUAMP00000033514Uncharacterized protein. (54 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
KIAA2012KIAA2012. (1131 aa)
SESN2Sestrin 2. (463 aa)
SPATA5L1Spermatogenesis associated 5 like 1. (755 aa)
EP300E1A binding protein p300. (2399 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (150 aa)
ENSUAMP00000007910BTB domain-containing protein. (106 aa)
MTFP1Mitochondrial fission process 1. (166 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
CREBBPCREB binding protein. (2333 aa)
RBX1Ring-box 1. (108 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSME2Proteasome activator subunit 2. (239 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
BACH1BTB domain and CNC homolog 1. (748 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (683 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (418 aa)
TRIM58Tripartite motif containing 58. (488 aa)
ENSUAMP00000003372Uncharacterized protein. (157 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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