STRINGSTRING
COMP COMP CD93 CD93 THBD THBD ENSUAMP00000002712 ENSUAMP00000002712 FBLN7 FBLN7 ENSUAMP00000002651 ENSUAMP00000002651 LTBP2 LTBP2 CRELD1 CRELD1 LRP6 LRP6 ENSUAMP00000001808 ENSUAMP00000001808 ADAM11 ADAM11 DLL3 DLL3 ITGB8 ITGB8 EGF EGF TMEFF2 TMEFF2 ENSUAMP00000001437 ENSUAMP00000001437 SCUBE2 SCUBE2 TIE1 TIE1 ENSUAMP00000001267 ENSUAMP00000001267 ENSUAMP00000000670 ENSUAMP00000000670 ITGB5 ITGB5 NCAN NCAN ENSUAMP00000008250 ENSUAMP00000008250 CNTNAP1 CNTNAP1 FBN1 FBN1 HABP2 HABP2 SCARF2 SCARF2 ENSUAMP00000009205 ENSUAMP00000009205 FAT2 FAT2 HHIP HHIP ENSUAMP00000009747 ENSUAMP00000009747 ENSUAMP00000009764 ENSUAMP00000009764 ATRNL1 ATRNL1 CD248 CD248 ADAM33 ADAM33 NID2 NID2 ATRN ATRN RSPO3 RSPO3 MEGF11 MEGF11 SORL1 SORL1 NID1 NID1 JAG1 JAG1 TNC TNC NOTCH1 NOTCH1 NOTCH2 NOTCH2 DLK2 DLK2 TENM2 TENM2 HMCN2 HMCN2 ADAM30 ADAM30 PLAT PLAT NPNT NPNT HBEGF HBEGF ENSUAMP00000030830 ENSUAMP00000030830 F12 F12 LTBP1 LTBP1 THBS4 THBS4 SLIT2 SLIT2 SLIT3 SLIT3 ENSUAMP00000029821 ENSUAMP00000029821 ENSUAMP00000029596 ENSUAMP00000029596 VWF VWF FBN3 FBN3 DLL1 DLL1 ENSUAMP00000028669 ENSUAMP00000028669 CELSR2 CELSR2 LRP4 LRP4 PAMR1 PAMR1 GAS6 GAS6 LRP1 LRP1 EDIL3 EDIL3 EGFL6 EGFL6 LTBP3 LTBP3 EFEMP2 EFEMP2 THBS3 THBS3 HGFAC HGFAC THBS2 THBS2 VLDLR VLDLR FBLN1 FBLN1 LRP5 LRP5 ENSUAMP00000025218 ENSUAMP00000025218 ENSUAMP00000025050 ENSUAMP00000025050 LRP2 LRP2 EGFLAM EGFLAM ENSUAMP00000024349 ENSUAMP00000024349 ENSUAMP00000023844 ENSUAMP00000023844 ENSUAMP00000023751 ENSUAMP00000023751 PTGS1 PTGS1 MATN1 MATN1 SELP SELP MEGF10 MEGF10 FBLN2 FBLN2 F9 F9 TENM4 TENM4 SCUBE1 SCUBE1 ENSUAMP00000011871 ENSUAMP00000011871 MFGE8 MFGE8 ENSUAMP00000012039 ENSUAMP00000012039 ENSUAMP00000012232 ENSUAMP00000012232 RELN RELN ENSUAMP00000012616 ENSUAMP00000012616 F10 F10 F7 F7 MEGF8 MEGF8 ENSUAMP00000014211 ENSUAMP00000014211 ENSUAMP00000014366 ENSUAMP00000014366 FAT4 FAT4 JAG2 JAG2 LTBP4 LTBP4 CSPG5 CSPG5 MEGF6 MEGF6 TECTA TECTA PROC PROC ENSUAMP00000015516 ENSUAMP00000015516 AREG AREG EREG EREG TENM3 TENM3 FAT1 FAT1 BCAN BCAN TMEFF1 TMEFF1 PEAR1 PEAR1 ADAM28 ADAM28 TEK TEK TDGF1 TDGF1 SCUBE3 SCUBE3 ENSUAMP00000018124 ENSUAMP00000018124 CELSR1 CELSR1 PLAU PLAU PTGS2 PTGS2 LDLR LDLR PGAP6 PGAP6 MMRN1 MMRN1 NOTCH4 NOTCH4 ENSUAMP00000020521 ENSUAMP00000020521 NRXN2 NRXN2 EGFL8 EGFL8 ENSUAMP00000020648 ENSUAMP00000020648 BTC BTC DLL4 DLL4 UMOD UMOD MEP1A MEP1A TNN TNN ENSUAMP00000021969 ENSUAMP00000021969 NAGPA NAGPA THBS1 THBS1 VWCE VWCE CELSR3 CELSR3 CRB2 CRB2 AGRN AGRN ENSUAMP00000022937 ENSUAMP00000022937 ENSUAMP00000023119 ENSUAMP00000023119 SELL SELL VASN VASN NTNG2 NTNG2 STAB1 STAB1 HYAL3 HYAL3 HYAL1 HYAL1 HYAL2 HYAL2 SLIT1 SLIT1 NOTCH3 NOTCH3 ENSUAMP00000003258 ENSUAMP00000003258 CCBE1 CCBE1 ENSUAMP00000035883 ENSUAMP00000035883 HYAL4 HYAL4 ENSUAMP00000008178 ENSUAMP00000008178 ATRAID ATRAID STAB2 STAB2 OIT3 OIT3 WIF1 WIF1 ENSUAMP00000004598 ENSUAMP00000004598 BRINP2 BRINP2 ENSUAMP00000003423 ENSUAMP00000003423 ADAM22 ADAM22 ENSUAMP00000003260 ENSUAMP00000003260
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COMPCartilage oligomeric matrix protein. (756 aa)
CD93CD93 molecule. (653 aa)
THBDThrombomodulin. (579 aa)
ENSUAMP00000002712Uncharacterized protein. (561 aa)
FBLN7Fibulin 7. (434 aa)
ENSUAMP00000002651C-type lectin domain-containing protein. (489 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1805 aa)
CRELD1Cysteine rich with EGF like domains 1. (531 aa)
LRP6LDL receptor related protein 6. (1431 aa)
ENSUAMP00000001808Uncharacterized protein. (821 aa)
ADAM11ADAM metallopeptidase domain 11. (823 aa)
DLL3Delta like canonical Notch ligand 3. (565 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
EGFEpidermal growth factor. (979 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
ENSUAMP00000001437Uncharacterized protein. (607 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1071 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1069 aa)
ENSUAMP00000001267Uncharacterized protein. (734 aa)
ENSUAMP00000000670Uncharacterized protein. (260 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (621 aa)
NCANNeurocan. (1333 aa)
ENSUAMP00000008250Uncharacterized protein. (334 aa)
CNTNAP1Contactin associated protein 1. (1352 aa)
FBN1Fibrillin 1. (2348 aa)
HABP2Hyaluronan binding protein 2. (556 aa)
SCARF2Scavenger receptor class F member 2. (746 aa)
ENSUAMP00000009205Uncharacterized protein. (892 aa)
FAT2FAT atypical cadherin 2. (4351 aa)
HHIPHedgehog interacting protein. (508 aa)
ENSUAMP00000009747Uncharacterized protein. (2955 aa)
ENSUAMP00000009764Uncharacterized protein. (496 aa)
ATRNL1Attractin like 1. (1188 aa)
CD248CD248 molecule. (729 aa)
ADAM33ADAM metallopeptidase domain 33. (799 aa)
NID2Nidogen 2. (1392 aa)
ATRNAttractin. (1419 aa)
RSPO3R-spondin 3. (275 aa)
MEGF11Multiple EGF like domains 11. (1014 aa)
SORL1Sortilin related receptor 1. (2210 aa)
NID1Nidogen 1. (1164 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
TNCTenascin C. (2201 aa)
NOTCH1Notch receptor 1. (2547 aa)
NOTCH2Notch receptor 2. (2374 aa)
DLK2Delta like non-canonical Notch ligand 2. (383 aa)
TENM2Teneurin transmembrane protein 2. (2654 aa)
HMCN2Hemicentin 2. (3939 aa)
ADAM30ADAM metallopeptidase domain 30. (747 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
NPNTNephronectin. (462 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ENSUAMP00000030830Uncharacterized protein. (290 aa)
F12Coagulation factor XII. (609 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1554 aa)
THBS4Thrombospondin 4. (944 aa)
SLIT2Slit guidance ligand 2. (1450 aa)
SLIT3Slit guidance ligand 3. (1441 aa)
ENSUAMP00000029821Uncharacterized protein. (413 aa)
ENSUAMP00000029596Uncharacterized protein. (288 aa)
VWFVon Willebrand factor. (2799 aa)
FBN3Fibrillin 3. (2819 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
ENSUAMP00000028669Uncharacterized protein. (677 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2928 aa)
LRP4LDL receptor related protein 4. (1852 aa)
PAMR1Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family. (728 aa)
GAS6Growth arrest specific 6. (655 aa)
LRP1LDL receptor related protein 1. (4548 aa)
EDIL3EGF like repeats and discoidin domains 3. (450 aa)
EGFL6EGF like domain multiple 6. (538 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1169 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
THBS3Thrombospondin 3. (1000 aa)
HGFACHGF activator. (656 aa)
THBS2Thrombospondin 2. (1172 aa)
VLDLRVery low density lipoprotein receptor. (892 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (670 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSUAMP00000025218EGF-like domain-containing protein. (275 aa)
ENSUAMP00000025050Uncharacterized protein. (456 aa)
LRP2LDL receptor related protein 2. (4684 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (881 aa)
ENSUAMP00000024349Uncharacterized protein. (666 aa)
ENSUAMP00000023844Uncharacterized protein. (734 aa)
ENSUAMP00000023751Uncharacterized protein. (407 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (618 aa)
MATN1Matrilin 1. (497 aa)
SELPSelectin P. (845 aa)
MEGF10Multiple EGF like domains 10. (1045 aa)
FBLN2Fibulin 2. (1228 aa)
F9Coagulation factor IX. (460 aa)
TENM4Teneurin transmembrane protein 4. (2640 aa)
SCUBE1Signal peptide, CUB domain and EGF like domain containing 1. (1036 aa)
ENSUAMP00000011871PLAC domain-containing protein. (308 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (419 aa)
ENSUAMP00000012039Uncharacterized protein. (457 aa)
ENSUAMP00000012232Uncharacterized protein. (938 aa)
RELNReelin. (3263 aa)
ENSUAMP00000012616Uncharacterized protein. (276 aa)
F10Coagulation factor X. (487 aa)
F7Coagulation factor VII. (446 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
ENSUAMP00000014211Uncharacterized protein. (1286 aa)
ENSUAMP00000014366Uncharacterized protein. (1290 aa)
FAT4FAT atypical cadherin 4. (4862 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1197 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1577 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (545 aa)
MEGF6Multiple EGF like domains 6. (1517 aa)
TECTATectorin alpha. (2155 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (477 aa)
ENSUAMP00000015516Uncharacterized protein. (1610 aa)
AREGAmphiregulin. (257 aa)
EREGEpiregulin. (175 aa)
TENM3Teneurin transmembrane protein 3. (2587 aa)
FAT1FAT atypical cadherin 1. (2954 aa)
BCANBrevican. (856 aa)
TMEFF1Transmembrane protein with EGF like and two follistatin like domains 1. (380 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1015 aa)
ADAM28ADAM metallopeptidase domain 28. (755 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (184 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (977 aa)
ENSUAMP00000018124Uncharacterized protein. (249 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2650 aa)
PLAUPlasminogen activator, urokinase; Belongs to the peptidase S1 family. (432 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
LDLRLow density lipoprotein receptor. (856 aa)
PGAP6Transmembrane protein 8A. (743 aa)
MMRN1Multimerin 1. (973 aa)
NOTCH4Notch receptor 4. (1894 aa)
ENSUAMP00000020521Uncharacterized protein. (327 aa)
NRXN2Uncharacterized protein. (969 aa)
EGFL8EGF like domain multiple 8. (306 aa)
ENSUAMP00000020648Uncharacterized protein. (1574 aa)
BTCBetacellulin. (164 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
UMODUromodulin. (649 aa)
MEP1AMetalloendopeptidase. (776 aa)
TNNTenascin N. (1408 aa)
ENSUAMP00000021969VWFA domain-containing protein. (355 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (569 aa)
THBS1Thrombospondin 1. (1170 aa)
VWCEVon Willebrand factor C and EGF domains. (880 aa)
CELSR3Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3309 aa)
CRB2Crumbs cell polarity complex component 2. (1280 aa)
AGRNAgrin. (2172 aa)
ENSUAMP00000022937Uncharacterized protein. (1204 aa)
ENSUAMP00000023119Uncharacterized protein. (607 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (371 aa)
VASNVasorin. (676 aa)
NTNG2Netrin G2. (565 aa)
STAB1Stabilin 1. (2556 aa)
HYAL3Hyaluronidase. (417 aa)
HYAL1Hyaluronidase. (435 aa)
HYAL2Hyaluronidase. (472 aa)
SLIT1Slit guidance ligand 1. (1514 aa)
NOTCH3Notch receptor 3. (2291 aa)
ENSUAMP00000003258Uncharacterized protein. (246 aa)
CCBE1Collagen and calcium binding EGF domains 1. (337 aa)
ENSUAMP00000035883Hyaluronidase. (502 aa)
HYAL4Hyaluronidase. (481 aa)
ENSUAMP00000008178Uncharacterized protein. (1633 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (229 aa)
STAB2Stabilin 2. (1614 aa)
OIT3Oncoprotein induced transcript 3. (554 aa)
WIF1WNT inhibitory factor 1. (354 aa)
ENSUAMP00000004598Uncharacterized protein. (299 aa)
BRINP2BMP/retinoic acid inducible neural specific 2. (770 aa)
ENSUAMP00000003423annotation not available (489 aa)
ADAM22ADAM metallopeptidase domain 22. (730 aa)
ENSUAMP00000003260Uncharacterized protein. (261 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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