47 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ESRRB	Estrogen related receptor beta. (454 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (482 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	VDR	Vitamin D receptor. (427 aa)
	NR0B2	Nuclear receptor subfamily 0 group B member 2. (301 aa)
	NR2F1	Nuclear receptor subfamily 2 group F member 1. (263 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	NR1I3	Nuclear receptor subfamily 1 group I member 3. (356 aa)
	NR2F2	Nuclear receptor subfamily 2 group F member 2. (414 aa)
	NR6A1	Nuclear receptor subfamily 6 group A member 1. (454 aa)
	NR2C1	Nuclear receptor subfamily 2 group C member 1. (631 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (781 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	ENSUAMP00000028186	Uncharacterized protein. (505 aa)
	ENSUAMP00000027845	Uncharacterized protein. (347 aa)
	THRB	Thyroid hormone receptor beta. (467 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	HNF4G	Hepatocyte nuclear factor 4 gamma. (408 aa)
	RORA	RAR related orphan receptor A. (522 aa)
	ESRRG	Estrogen related receptor gamma. (435 aa)
	RORC	RAR related orphan receptor C. (517 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (546 aa)
	THRA	Thyroid hormone receptor alpha. (511 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (600 aa)
	ESRRA	Estrogen related receptor alpha. (422 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (455 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	ENSUAMP00000017524	Uncharacterized protein. (542 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (619 aa)
	ENSUAMP00000016402	Uncharacterized protein. (427 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	RORB	RAR related orphan receptor B. (502 aa)
	NR2F6	Nuclear receptor subfamily 2 group F member 6. (388 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	AR	Androgen receptor. (905 aa)
	NR1I2	Nuclear receptor subfamily 1 group I member 2. (379 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (503 aa)
	ENSUAMP00000010069	Uncharacterized protein. (357 aa)
	NR2E3	Nuclear receptor subfamily 2 group E member 3. (411 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
	NR2C2	Nuclear receptor subfamily 2 group C member 2. (629 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ENSUAMP00000016402	ENSUAMP00000013075	ENSUAMP00000016402	Androgen receptor.	Uncharacterized protein.	0.544
AR	ESR1	ENSUAMP00000013075	ENSUAMP00000006270	Androgen receptor.	Estrogen receptor 1.	0.587
AR	NR3C1	ENSUAMP00000013075	ENSUAMP00000029768	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.582
ENSUAMP00000016402	AR	ENSUAMP00000016402	ENSUAMP00000013075	Uncharacterized protein.	Androgen receptor.	0.544
ENSUAMP00000016402	NR3C1	ENSUAMP00000016402	ENSUAMP00000029768	Uncharacterized protein.	Nuclear receptor subfamily 3 group C member 1.	0.846
ENSUAMP00000017524	ENSUAMP00000027845	ENSUAMP00000017524	ENSUAMP00000027845	Uncharacterized protein.	Uncharacterized protein.	0.486
ENSUAMP00000017524	NR4A2	ENSUAMP00000017524	ENSUAMP00000015464	Uncharacterized protein.	Nuclear receptor subfamily 4 group A member 2.	0.429
ENSUAMP00000017524	NR4A3	ENSUAMP00000017524	ENSUAMP00000016872	Uncharacterized protein.	Nuclear receptor subfamily 4 group A member 3.	0.607
ENSUAMP00000017524	RXRA	ENSUAMP00000017524	ENSUAMP00000026794	Uncharacterized protein.	Retinoid X receptor alpha.	0.907
ENSUAMP00000017524	RXRB	ENSUAMP00000017524	ENSUAMP00000035462	Uncharacterized protein.	Retinoid X receptor beta.	0.461
ENSUAMP00000027845	ENSUAMP00000017524	ENSUAMP00000027845	ENSUAMP00000017524	Uncharacterized protein.	Uncharacterized protein.	0.486
ENSUAMP00000027845	ENSUAMP00000028186	ENSUAMP00000027845	ENSUAMP00000028186	Uncharacterized protein.	Uncharacterized protein.	0.736
ENSUAMP00000027845	NR1D2	ENSUAMP00000027845	ENSUAMP00000019629	Uncharacterized protein.	Nuclear receptor subfamily 1 group D member 2.	0.441
ENSUAMP00000027845	NR1H2	ENSUAMP00000027845	ENSUAMP00000018908	Uncharacterized protein.	Nuclear receptor subfamily 1 group H member 2.	0.834
ENSUAMP00000027845	NR1H3	ENSUAMP00000027845	ENSUAMP00000003082	Uncharacterized protein.	Nuclear receptor subfamily 1 group H member 3.	0.840
ENSUAMP00000027845	NR1H4	ENSUAMP00000027845	ENSUAMP00000036456	Uncharacterized protein.	Nuclear receptor subfamily 1 group H member 4.	0.812
ENSUAMP00000027845	NR1I2	ENSUAMP00000027845	ENSUAMP00000012091	Uncharacterized protein.	Nuclear receptor subfamily 1 group I member 2.	0.689
ENSUAMP00000027845	NR1I3	ENSUAMP00000027845	ENSUAMP00000033432	Uncharacterized protein.	Nuclear receptor subfamily 1 group I member 3.	0.761
ENSUAMP00000027845	NR4A2	ENSUAMP00000027845	ENSUAMP00000015464	Uncharacterized protein.	Nuclear receptor subfamily 4 group A member 2.	0.408
ENSUAMP00000027845	NR4A3	ENSUAMP00000027845	ENSUAMP00000016872	Uncharacterized protein.	Nuclear receptor subfamily 4 group A member 3.	0.408