(63 nodes) Valine, leucine and isoleucine degradation network (Ursus americanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALDH16A1	Aldehyde dehydrogenase family 16 member A1. (819 aa)
	ENSUAMP00000000256	Amine oxidase. (526 aa)
	ENSUAMP00000000294	Uncharacterized protein. (264 aa)
	ENSUAMP00000000440	Uncharacterized protein. (288 aa)
	HIBCH	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa)
	MCEE	Methylmalonyl-CoA epimerase. (170 aa)
	IVD	Isovaleryl-CoA dehydrogenase. (426 aa)
	ENSUAMP00000001835	Aldedh domain-containing protein. (222 aa)
	IL4I1	Interleukin 4 induced 1. (572 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (345 aa)
	SETD4	SET domain containing 4. (355 aa)
	AACS	Acetoacetyl-CoA synthetase. (486 aa)
	ALDH1B1	Aldehyde dehydrogenase 1 family member B1. (491 aa)
	CARTPT	CART prepropeptide. (128 aa)
	ACAA1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (414 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (534 aa)
	ENSUAMP00000008464	Uncharacterized protein. (283 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
	BCKDHB	Branched chain keto acid dehydrogenase E1 subunit beta. (318 aa)
	ACADSB	Acyl-CoA dehydrogenase short/branched chain. (439 aa)
	TTLL12	Tubulin tyrosine ligase like 12. (650 aa)
	ACAA2	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	MCCC1	Methylcrotonoyl-CoA carboxylase 1. (543 aa)
	HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
	HADHA	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (812 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (330 aa)
	ENSUAMP00000010986	APH domain-containing protein. (436 aa)
	ALDH7A1	Aldehyde dehydrogenase 7 family member A1. (459 aa)
	ENSUAMP00000012476	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (466 aa)
	ENSUAMP00000012555	Uncharacterized protein. (284 aa)
	BCAT2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (463 aa)
	HSD17B14	Hydroxysteroid 17-beta dehydrogenase 14. (336 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)
	ENSUAMP00000013944	Uncharacterized protein. (1357 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (421 aa)
	ENSUAMP00000017155	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (518 aa)
	ACADS	Acyl-CoA dehydrogenase short chain. (412 aa)
	ENSUAMP00000019038	CoA carboxyltransferase N-terminal domain-containing protein. (294 aa)
	AOX1	Aldehyde oxidase 1. (1332 aa)
	ENSUAMP00000020181	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (171 aa)
	ECHS1	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	ECHDC2	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (287 aa)
	SETD3	Protein-histidine N-methyltransferase. (591 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
	PCCA	Propionyl-CoA carboxylase subunit alpha. (573 aa)
	TNPO2	Transportin 2. (897 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (522 aa)
	MMUT	Methylmalonyl-CoA mutase. (750 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (501 aa)
	HIBADH	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (336 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (513 aa)
	ENSUAMP00000030237	Uncharacterized protein. (68 aa)
	ENSUAMP00000030815	Importin N-terminal domain-containing protein. (136 aa)
	HSD17B10	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	ACAD8	Acyl-CoA dehydrogenase family member 8. (415 aa)
	ACSF3	Acyl-CoA synthetase family member 3. (537 aa)
	AUH	AU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (331 aa)
	ENSUAMP00000032679	CoA carboxyltransferase N-terminal domain-containing protein. (212 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	ENSUAMP00000033191	APH domain-containing protein. (583 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (374 aa)
	ENSUAMP00000037010	Uncharacterized protein. (325 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAA1	ENSUAMP00000004741	ENSUAMP00000006012	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.512
AACS	ACAA2	ENSUAMP00000004741	ENSUAMP00000010549	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.586
AACS	ACAT1	ENSUAMP00000004741	ENSUAMP00000008810	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.927
AACS	ACSF3	ENSUAMP00000004741	ENSUAMP00000031753	Acetoacetyl-CoA synthetase.	Acyl-CoA synthetase family member 3.	0.474
AACS	ALDH16A1	ENSUAMP00000004741	ENSUAMP00000010144	Acetoacetyl-CoA synthetase.	Aldehyde dehydrogenase family 16 member A1.	0.423
AACS	ALDH1B1	ENSUAMP00000004741	ENSUAMP00000005639	Acetoacetyl-CoA synthetase.	Aldehyde dehydrogenase 1 family member B1.	0.423
AACS	ALDH3A2	ENSUAMP00000004741	ENSUAMP00000027350	Acetoacetyl-CoA synthetase.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.438
AACS	ALDH7A1	ENSUAMP00000004741	ENSUAMP00000011631	Acetoacetyl-CoA synthetase.	Aldehyde dehydrogenase 7 family member A1.	0.429
AACS	AUH	ENSUAMP00000004741	ENSUAMP00000032001	Acetoacetyl-CoA synthetase.	AU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.404
AACS	CARTPT	ENSUAMP00000004741	ENSUAMP00000005831	Acetoacetyl-CoA synthetase.	CART prepropeptide.	0.531
AACS	ECHDC2	ENSUAMP00000004741	ENSUAMP00000021353	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family.	0.404
AACS	ECHS1	ENSUAMP00000004741	ENSUAMP00000020528	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.443
AACS	ENSUAMP00000000294	ENSUAMP00000004741	ENSUAMP00000000294	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.838
AACS	ENSUAMP00000000440	ENSUAMP00000004741	ENSUAMP00000000440	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.838
AACS	ENSUAMP00000001835	ENSUAMP00000004741	ENSUAMP00000001835	Acetoacetyl-CoA synthetase.	Aldedh domain-containing protein.	0.423
AACS	ENSUAMP00000008464	ENSUAMP00000004741	ENSUAMP00000008464	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.951
AACS	ENSUAMP00000012476	ENSUAMP00000004741	ENSUAMP00000012476	Acetoacetyl-CoA synthetase.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.424
AACS	ENSUAMP00000012555	ENSUAMP00000004741	ENSUAMP00000012555	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.851
AACS	ENSUAMP00000017155	ENSUAMP00000004741	ENSUAMP00000017155	Acetoacetyl-CoA synthetase.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.423
AACS	ENSUAMP00000020181	ENSUAMP00000004741	ENSUAMP00000020181	Acetoacetyl-CoA synthetase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.917