(80 nodes) Pyruvate metabolism network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ME2	Malic enzyme. (547 aa)
	ENSUAMP00000019554	Uncharacterized protein. (434 aa)
	ENSUAMP00000019553	Uncharacterized protein. (82 aa)
	URB2	URB2 ribosome biogenesis homolog. (1521 aa)
	ENSUAMP00000018782	BBS1 domain-containing protein. (623 aa)
	CLPTM1L	CLPTM1 like. (538 aa)
	ENSUAMP00000017482	Uncharacterized protein. (228 aa)
	ENSUAMP00000017206	VOC domain-containing protein. (103 aa)
	ENSUAMP00000017155	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (518 aa)
	ENSUAMP00000017019	Acylphosphatase. (158 aa)
	MDH1	Malate dehydrogenase. (321 aa)
	HAGH	Hydroxyacylglutathione hydrolase. (364 aa)
	ACOT11	Acyl-CoA thioesterase 11. (539 aa)
	ENSUAMP00000016577	Uncharacterized protein. (135 aa)
	ME1	Malic enzyme. (580 aa)
	HAGHL	Hydroxyacylglutathione hydrolase like. (283 aa)
	GRHPR	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	ENSUAMP00000015522	Uncharacterized protein. (666 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2045 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (212 aa)
	PDHA2	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
	NOP53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (469 aa)
	ENSUAMP00000036717	Acylphosphatase-like domain-containing protein; Belongs to the acylphosphatase family. (126 aa)
	ENSUAMP00000036260	Uncharacterized protein. (1033 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	KIFC1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (647 aa)
	ENSUAMP00000033916	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	PARP6	Poly [ADP-ribose] polymerase. (610 aa)
	TSR1	TSR1 ribosome maturation factor. (815 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	TMEM104	Transmembrane protein 104. (496 aa)
	CLPTM1	CLPTM1 regulator of GABA type A receptor forward trafficking. (668 aa)
	KIFC3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (945 aa)
	ACOT12	Acyl-CoA thioesterase 12. (460 aa)
	FAM114A2	Family with sequence similarity 114 member A2. (472 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (501 aa)
	ENSUAMP00000027178	Acylphosphatase. (98 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (563 aa)
	ENSUAMP00000026055	Ldh_1_C domain-containing protein. (101 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	FH	Fumarate hydratase. (493 aa)
	ENSUAMP00000000220	Uncharacterized protein. (142 aa)
	PNKD	PNKD metallo-beta-lactamase domain containing. (360 aa)
	ENSUAMP00000001439	Ldh_1_C domain-containing protein. (58 aa)
	ENSUAMP00000001835	Aldedh domain-containing protein. (222 aa)
	ENSUAMP00000003971	Ldh_1_C domain-containing protein. (101 aa)
	ENSUAMP00000005190	Ldh_1_N domain-containing protein. (221 aa)
	SLC25A3	Solute carrier family 25 member 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (361 aa)
	ALDH1B1	Aldehyde dehydrogenase 1 family member B1. (491 aa)
	ENSUAMP00000005719	Ldh_1_N domain-containing protein. (127 aa)
	CARTPT	CART prepropeptide. (128 aa)
	LACTB2	Lactamase beta 2. (272 aa)
	ENSUAMP00000007578	ACAS_N domain-containing protein. (194 aa)
	KIFC2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (781 aa)
	ENSUAMP00000008512	Biotin carboxylation domain-containing protein. (206 aa)
	MBLAC2	Metallo-beta-lactamase domain containing 2. (279 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
	RNF138	Ring finger protein 138. (245 aa)
	TTLL12	Tubulin tyrosine ligase like 12. (650 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1190 aa)
	ALDH16A1	Aldehyde dehydrogenase family 16 member A1. (819 aa)
	ENSUAMP00000011307	Uncharacterized protein. (1315 aa)
	ENSUAMP00000011425	Malic domain-containing protein. (254 aa)
	ENSUAMP00000011619	Malic_M domain-containing protein. (256 aa)
	ALDH7A1	Aldehyde dehydrogenase 7 family member A1. (459 aa)
	LDHA	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	ENSUAMP00000024473	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (179 aa)
	ENSUAMP00000024472	Ldh_1_C domain-containing protein. (55 aa)
	LDHAL6B	L-lactate dehydrogenase. (236 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	ENSUAMP00000023215	Uncharacterized protein. (59 aa)
	PARP8	Poly [ADP-ribose] polymerase. (515 aa)
	ENSUAMP00000022865	ACAS_N domain-containing protein. (125 aa)
	LDHD	Lactate dehydrogenase D. (485 aa)
	ENSUAMP00000020654	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (337 aa)
	ENSUAMP00000020181	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (171 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ACAT1	ENSUAMP00000013160	ENSUAMP00000008810	Acetyl-CoA carboxylase beta.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.891
ACACB	ACOT12	ENSUAMP00000013160	ENSUAMP00000028173	Acetyl-CoA carboxylase beta.	Acyl-CoA thioesterase 12.	0.863
ACACB	CARTPT	ENSUAMP00000013160	ENSUAMP00000005831	Acetyl-CoA carboxylase beta.	CART prepropeptide.	0.418
ACACB	DLAT	ENSUAMP00000013160	ENSUAMP00000023716	Acetyl-CoA carboxylase beta.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.874
ACACB	ENSUAMP00000007578	ENSUAMP00000013160	ENSUAMP00000007578	Acetyl-CoA carboxylase beta.	ACAS_N domain-containing protein.	0.899
ACACB	ENSUAMP00000008512	ENSUAMP00000013160	ENSUAMP00000008512	Acetyl-CoA carboxylase beta.	Biotin carboxylation domain-containing protein.	0.923
ACACB	ENSUAMP00000011307	ENSUAMP00000013160	ENSUAMP00000011307	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.797
ACACB	ENSUAMP00000015522	ENSUAMP00000013160	ENSUAMP00000015522	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.861
ACACB	ENSUAMP00000020181	ENSUAMP00000013160	ENSUAMP00000020181	Acetyl-CoA carboxylase beta.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.885
ACACB	ENSUAMP00000022865	ENSUAMP00000013160	ENSUAMP00000022865	Acetyl-CoA carboxylase beta.	ACAS_N domain-containing protein.	0.861
ACACB	ENSUAMP00000036260	ENSUAMP00000013160	ENSUAMP00000036260	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.795
ACACB	PC	ENSUAMP00000013160	ENSUAMP00000010131	Acetyl-CoA carboxylase beta.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.547
ACACB	PCK1	ENSUAMP00000013160	ENSUAMP00000025391	Acetyl-CoA carboxylase beta.	Phosphoenolpyruvate carboxykinase 1.	0.425
ACACB	PCK2	ENSUAMP00000013160	ENSUAMP00000031312	Acetyl-CoA carboxylase beta.	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	0.442
ACAT1	ACACB	ENSUAMP00000008810	ENSUAMP00000013160	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase beta.	0.891
ACAT1	ACOT11	ENSUAMP00000008810	ENSUAMP00000016607	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA thioesterase 11.	0.412
ACAT1	ACOT12	ENSUAMP00000008810	ENSUAMP00000028173	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA thioesterase 12.	0.958
ACAT1	DLAT	ENSUAMP00000008810	ENSUAMP00000023716	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.955
ACAT1	ENSUAMP00000007578	ENSUAMP00000008810	ENSUAMP00000007578	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	ACAS_N domain-containing protein.	0.969
ACAT1	ENSUAMP00000008512	ENSUAMP00000008810	ENSUAMP00000008512	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Biotin carboxylation domain-containing protein.	0.891