STRINGSTRING
HIBCH HIBCH MCEE MCEE ENSUAMP00000001439 ENSUAMP00000001439 ACSS3 ACSS3 SUCLA2 SUCLA2 ENSUAMP00000003971 ENSUAMP00000003971 ACOX1 ACOX1 SUCLG1 SUCLG1 SETD4 SETD4 ENSUAMP00000004654 ENSUAMP00000004654 ENSUAMP00000005719 ENSUAMP00000005719 ENSUAMP00000005190 ENSUAMP00000005190 CARTPT CARTPT ALDH6A1 ALDH6A1 MLYCD MLYCD ENSUAMP00000007578 ENSUAMP00000007578 ENSUAMP00000008512 ENSUAMP00000008512 ACAT1 ACAT1 BCKDHB BCKDHB RNF138 RNF138 ENSUAMP00000010665 ENSUAMP00000010665 HADHA HADHA ENSUAMP00000011307 ENSUAMP00000011307 ENSUAMP00000012476 ENSUAMP00000012476 ENSUAMP00000012555 ENSUAMP00000012555 DLD DLD ACACB ACACB ACOX3 ACOX3 ENSUAMP00000015522 ENSUAMP00000015522 ENSUAMP00000017482 ENSUAMP00000017482 ACADS ACADS ENSUAMP00000019038 ENSUAMP00000019038 ENSUAMP00000020181 ENSUAMP00000020181 ECHS1 ECHS1 SETD3 SETD3 DBT DBT ENSUAMP00000022865 ENSUAMP00000022865 LDHAL6B LDHAL6B ENSUAMP00000024472 ENSUAMP00000024472 ENSUAMP00000024473 ENSUAMP00000024473 LDHA LDHA PCCA PCCA ENSUAMP00000026055 ENSUAMP00000026055 ABAT ABAT MMUT MMUT FAM114A2 FAM114A2 ENSUAMP00000030237 ENSUAMP00000030237 ENSUAMP00000030633 ENSUAMP00000030633 ENSUAMP00000033134 ENSUAMP00000033134 ENSUAMP00000036260 ENSUAMP00000036260
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa)
MCEEMethylmalonyl-CoA epimerase. (170 aa)
ENSUAMP00000001439Ldh_1_C domain-containing protein. (58 aa)
ACSS3Acyl-CoA synthetase short chain family member 3. (688 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
ENSUAMP00000003971Ldh_1_C domain-containing protein. (101 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (655 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
SETD4SET domain containing 4. (355 aa)
ENSUAMP000000046543-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (125 aa)
ENSUAMP00000005719Ldh_1_N domain-containing protein. (127 aa)
ENSUAMP00000005190Ldh_1_N domain-containing protein. (221 aa)
CARTPTCART prepropeptide. (128 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (534 aa)
MLYCDMalonyl-CoA decarboxylase. (500 aa)
ENSUAMP00000007578ACAS_N domain-containing protein. (194 aa)
ENSUAMP00000008512Biotin carboxylation domain-containing protein. (206 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (318 aa)
RNF138Ring finger protein 138. (245 aa)
ENSUAMP00000010665Helicase ATP-binding domain-containing protein. (451 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (812 aa)
ENSUAMP00000011307Uncharacterized protein. (1315 aa)
ENSUAMP000000124762-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (466 aa)
ENSUAMP00000012555Uncharacterized protein. (284 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
ACACBAcetyl-CoA carboxylase beta. (2045 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
ENSUAMP00000015522Uncharacterized protein. (666 aa)
ENSUAMP00000017482Uncharacterized protein. (228 aa)
ACADSAcyl-CoA dehydrogenase short chain. (412 aa)
ENSUAMP00000019038CoA carboxyltransferase N-terminal domain-containing protein. (294 aa)
ENSUAMP00000020181Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (171 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
SETD3Protein-histidine N-methyltransferase. (591 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
ENSUAMP00000022865ACAS_N domain-containing protein. (125 aa)
LDHAL6BL-lactate dehydrogenase. (236 aa)
ENSUAMP00000024472Ldh_1_C domain-containing protein. (55 aa)
ENSUAMP00000024473L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (179 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PCCAPropionyl-CoA carboxylase subunit alpha. (573 aa)
ENSUAMP00000026055Ldh_1_C domain-containing protein. (101 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (522 aa)
MMUTMethylmalonyl-CoA mutase. (750 aa)
FAM114A2Family with sequence similarity 114 member A2. (472 aa)
ENSUAMP00000030237Uncharacterized protein. (68 aa)
ENSUAMP00000030633Uncharacterized protein. (1144 aa)
ENSUAMP00000033134Uncharacterized protein. (89 aa)
ENSUAMP00000036260Uncharacterized protein. (1033 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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