(18 nodes) Thiamine metabolism network (Ursus americanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	ALPL	Alkaline phosphatase. (524 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (245 aa)
	ENSUAMP00000016857	Uncharacterized protein. (76 aa)
	ENSUAMP00000026526	Alkaline phosphatase. (590 aa)
	CHM	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (623 aa)
	AK7	Adenylate kinase 7. (718 aa)
	AK2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
	ENSUAMP00000020703	TPK_catalytic domain-containing protein. (251 aa)
	ENSUAMP00000022081	LMWPc domain-containing protein. (118 aa)
	CPPED1	Calcineurin like phosphoesterase domain containing 1. (268 aa)
	THTPA	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa)
	ENSUAMP00000012934	Aminotran_5 domain-containing protein. (457 aa)
	AK8	Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa)
	PXYLP1	2-phosphoxylose phosphatase 1; Belongs to the histidine acid phosphatase family. (481 aa)
	NTPCR	Nucleoside-triphosphatase, cancer-related. (198 aa)
	ENSUAMP00000001002	Uncharacterized protein. (86 aa)
	ACP7	Purple acid phosphatase. (415 aa)
	ENSUAMP00000029404	LMWPc domain-containing protein. (158 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP7	ALPL	ENSUAMP00000028022	ENSUAMP00000029843	Purple acid phosphatase.	Alkaline phosphatase.	0.551
ACP7	ENSUAMP00000022081	ENSUAMP00000028022	ENSUAMP00000022081	Purple acid phosphatase.	LMWPc domain-containing protein.	0.548
ACP7	ENSUAMP00000026526	ENSUAMP00000028022	ENSUAMP00000026526	Purple acid phosphatase.	Alkaline phosphatase.	0.551
ACP7	ENSUAMP00000029404	ENSUAMP00000028022	ENSUAMP00000029404	Purple acid phosphatase.	LMWPc domain-containing protein.	0.548
AK1	AK2	ENSUAMP00000030019	ENSUAMP00000019257	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.958
AK1	AK7	ENSUAMP00000030019	ENSUAMP00000033789	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 7.	0.970
AK1	AK8	ENSUAMP00000030019	ENSUAMP00000032472	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.911
AK1	ENSUAMP00000016857	ENSUAMP00000030019	ENSUAMP00000016857	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Uncharacterized protein.	0.944
AK1	ENSUAMP00000020703	ENSUAMP00000030019	ENSUAMP00000020703	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	TPK_catalytic domain-containing protein.	0.953
AK1	NTPCR	ENSUAMP00000030019	ENSUAMP00000003821	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Nucleoside-triphosphatase, cancer-related.	0.945
AK1	THTPA	ENSUAMP00000030019	ENSUAMP00000008963	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP).	0.965
AK2	AK1	ENSUAMP00000019257	ENSUAMP00000030019	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.958
AK2	AK7	ENSUAMP00000019257	ENSUAMP00000033789	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Adenylate kinase 7.	0.953
AK2	AK8	ENSUAMP00000019257	ENSUAMP00000032472	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.923
AK2	ENSUAMP00000001002	ENSUAMP00000019257	ENSUAMP00000001002	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Uncharacterized protein.	0.907
AK2	ENSUAMP00000016857	ENSUAMP00000019257	ENSUAMP00000016857	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Uncharacterized protein.	0.955
AK2	ENSUAMP00000020703	ENSUAMP00000019257	ENSUAMP00000020703	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	TPK_catalytic domain-containing protein.	0.947
AK2	NTPCR	ENSUAMP00000019257	ENSUAMP00000003821	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Nucleoside-triphosphatase, cancer-related.	0.984
AK2	THTPA	ENSUAMP00000019257	ENSUAMP00000008963	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP).	0.938
AK7	AK1	ENSUAMP00000033789	ENSUAMP00000030019	Adenylate kinase 7.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.970