(64 nodes) Metabolism of xenobiotics by cytochrome P450 network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSTT4	Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
	ENSUAMP00000000355	Uncharacterized protein. (58 aa)
	ENSUAMP00000000505	Uncharacterized protein. (231 aa)
	ENSUAMP00000000729	Uncharacterized protein; Belongs to the cytochrome P450 family. (180 aa)
	C2orf69	Chromosome 2 open reading frame 69. (373 aa)
	ENSUAMP00000001533	Uncharacterized protein. (98 aa)
	ENSUAMP00000001920	Uncharacterized protein. (229 aa)
	GSTO2	Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
	GSTO1	Glutathione S-transferase omega 1; Belongs to the GST superfamily. (278 aa)
	ENSUAMP00000003052	Uncharacterized protein. (372 aa)
	ADH6	Alcohol dehydrogenase 6 (class V). (400 aa)
	ENSUAMP00000003267	Aldo_ket_red domain-containing protein. (354 aa)
	ENSUAMP00000003631	Uncharacterized protein. (189 aa)
	ENSUAMP00000003787	Uncharacterized protein. (209 aa)
	ENSUAMP00000003802	Uncharacterized protein. (368 aa)
	GSTM3	Glutathione S-transferase. (226 aa)
	ENSUAMP00000004109	Uncharacterized protein; Belongs to the GST superfamily. (256 aa)
	ENSUAMP00000004224	Uncharacterized protein. (169 aa)
	ENSUAMP00000004597	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa)
	ENSUAMP00000005042	Uncharacterized protein. (463 aa)
	ENSUAMP00000005458	Uncharacterized protein. (51 aa)
	ENSUAMP00000006241	GST N-terminal domain-containing protein. (60 aa)
	ENSUAMP00000006430	Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
	ENSUAMP00000008117	Uncharacterized protein. (230 aa)
	ENSUAMP00000009040	GST N-terminal domain-containing protein. (150 aa)
	ENSUAMP00000009042	Uncharacterized protein. (158 aa)
	ENSUAMP00000009044	Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
	GSTA4	Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (223 aa)
	ENSUAMP00000010632	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	ENSUAMP00000011012	Aldedh domain-containing protein. (225 aa)
	UGT1A1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
	ENSUAMP00000012071	GST N-terminal domain-containing protein. (193 aa)
	ENSUAMP00000013015	DSBA domain-containing protein. (172 aa)
	DHDH	Dihydrodiol dehydrogenase. (335 aa)
	EPHX1	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (444 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (512 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (494 aa)
	ENSUAMP00000032777	Uncharacterized protein. (323 aa)
	HSD11B1L	Hydroxysteroid 11-beta dehydrogenase 1 like. (291 aa)
	ENSUAMP00000031741	Uncharacterized protein. (295 aa)
	ENSUAMP00000031737	Uncharacterized protein. (187 aa)
	ALDH3B2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (451 aa)
	MGST2	Microsomal glutathione S-transferase 2. (146 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	ENSUAMP00000027042	ADH_N domain-containing protein. (95 aa)
	GSTK1	Glutathione S-transferase kappa. (190 aa)
	ENSUAMP00000024904	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (405 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	ENSUAMP00000021744	Uncharacterized protein. (353 aa)
	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	ENSUAMP00000018414	Uncharacterized protein; Belongs to the cytochrome P450 family. (404 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (491 aa)
	MGST3	Microsomal glutathione S-transferase 3. (152 aa)
	ENSUAMP00000014798	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (380 aa)
	ENSUAMP00000014595	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	ENSUAMP00000014003	Aldedh domain-containing protein. (131 aa)
	ENSUAMP00000013435	Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
	ENSUAMP00000013433	Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
	ENSUAMP00000013425	Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
	ENSUAMP00000013421	Uncharacterized protein. (240 aa)
	ENSUAMP00000013261	Uncharacterized protein. (134 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH4	ADH6	ENSUAMP00000014759	ENSUAMP00000003243	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Alcohol dehydrogenase 6 (class V).	0.836
ADH4	ALDH3B2	ENSUAMP00000014759	ENSUAMP00000031679	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.894
ADH4	CYP2E1	ENSUAMP00000014759	ENSUAMP00000033866	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	0.877
ADH4	CYP2F1	ENSUAMP00000014759	ENSUAMP00000017395	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family.	0.561
ADH4	ENSUAMP00000000729	ENSUAMP00000014759	ENSUAMP00000000729	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.561
ADH4	ENSUAMP00000001920	ENSUAMP00000014759	ENSUAMP00000001920	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.856
ADH4	ENSUAMP00000003052	ENSUAMP00000014759	ENSUAMP00000003052	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.873
ADH4	ENSUAMP00000003787	ENSUAMP00000014759	ENSUAMP00000003787	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.814
ADH4	ENSUAMP00000003802	ENSUAMP00000014759	ENSUAMP00000003802	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.873
ADH4	ENSUAMP00000004109	ENSUAMP00000014759	ENSUAMP00000004109	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.856
ADH4	ENSUAMP00000005042	ENSUAMP00000014759	ENSUAMP00000005042	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.561
ADH4	ENSUAMP00000005458	ENSUAMP00000014759	ENSUAMP00000005458	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.914
ADH4	ENSUAMP00000006241	ENSUAMP00000014759	ENSUAMP00000006241	Alcohol dehydrogenase 4 (class II), pi polypeptide.	GST N-terminal domain-containing protein.	0.814
ADH4	ENSUAMP00000006430	ENSUAMP00000014759	ENSUAMP00000006430	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.814
ADH4	ENSUAMP00000008117	ENSUAMP00000014759	ENSUAMP00000008117	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.856
ADH4	ENSUAMP00000009040	ENSUAMP00000014759	ENSUAMP00000009040	Alcohol dehydrogenase 4 (class II), pi polypeptide.	GST N-terminal domain-containing protein.	0.878
ADH4	ENSUAMP00000009042	ENSUAMP00000014759	ENSUAMP00000009042	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.878
ADH4	ENSUAMP00000009044	ENSUAMP00000014759	ENSUAMP00000009044	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.906
ADH4	ENSUAMP00000010632	ENSUAMP00000014759	ENSUAMP00000010632	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.561
ADH4	ENSUAMP00000011012	ENSUAMP00000014759	ENSUAMP00000011012	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldedh domain-containing protein.	0.902