(57 nodes) Drug metabolism - cytochrome P450 network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRRC2C	Proline rich coiled-coil 2C. (2758 aa)
	ENSUAMP00000013433	Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
	ENSUAMP00000013435	Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
	MAOA	Amine oxidase. (417 aa)
	ENSUAMP00000013944	Uncharacterized protein. (1357 aa)
	ENSUAMP00000014003	Aldedh domain-containing protein. (131 aa)
	ENSUAMP00000014595	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (380 aa)
	ENSUAMP00000014798	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
	PRRC2A	Proline rich coiled-coil 2A. (2166 aa)
	MGST3	Microsomal glutathione S-transferase 3. (152 aa)
	ENSUAMP00000018378	Amino_oxidase domain-containing protein. (141 aa)
	AOX1	Aldehyde oxidase 1. (1332 aa)
	ENSUAMP00000021744	Uncharacterized protein. (353 aa)
	ENSUAMP00000023021	Flavin-containing monooxygenase. (254 aa)
	ENSUAMP00000003802	Uncharacterized protein. (368 aa)
	GSTM3	Glutathione S-transferase. (226 aa)
	ENSUAMP00000004109	Uncharacterized protein; Belongs to the GST superfamily. (256 aa)
	ENSUAMP00000005458	Uncharacterized protein. (51 aa)
	ENSUAMP00000006241	GST N-terminal domain-containing protein. (60 aa)
	ENSUAMP00000006430	Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
	ENSUAMP00000008117	Uncharacterized protein. (230 aa)
	ENSUAMP00000009040	GST N-terminal domain-containing protein. (150 aa)
	ENSUAMP00000009042	Uncharacterized protein. (158 aa)
	ENSUAMP00000009044	Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
	GSTA4	Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (223 aa)
	PRRC2B	Proline rich coiled-coil 2B. (2205 aa)
	ENSUAMP00000011012	Aldedh domain-containing protein. (225 aa)
	UGT1A1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
	ENSUAMP00000012071	GST N-terminal domain-containing protein. (193 aa)
	ENSUAMP00000013015	DSBA domain-containing protein. (172 aa)
	ENSUAMP00000013421	Uncharacterized protein. (240 aa)
	ENSUAMP00000013425	Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
	ENSUAMP00000023027	Flavin-containing monooxygenase. (185 aa)
	ENSUAMP00000024904	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (405 aa)
	GSTK1	Glutathione S-transferase kappa. (190 aa)
	ENSUAMP00000027042	ADH_N domain-containing protein. (95 aa)
	FMO5	Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	MGST2	Microsomal glutathione S-transferase 2. (146 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (556 aa)
	ALDH3B2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (451 aa)
	ENSUAMP00000032777	Uncharacterized protein. (323 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (494 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (512 aa)
	MAOB	Amine oxidase. (529 aa)
	ENSUAMP00000003787	Uncharacterized protein. (209 aa)
	ADH6	Alcohol dehydrogenase 6 (class V). (400 aa)
	ENSUAMP00000003052	Uncharacterized protein. (372 aa)
	GSTO1	Glutathione S-transferase omega 1; Belongs to the GST superfamily. (278 aa)
	GSTO2	Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
	ENSUAMP00000001920	Uncharacterized protein. (229 aa)
	ENSUAMP00000001533	Uncharacterized protein. (98 aa)
	ENSUAMP00000001018	Flavin-containing monooxygenase. (265 aa)
	GSTT4	Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH4	ADH6	ENSUAMP00000014759	ENSUAMP00000003243	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Alcohol dehydrogenase 6 (class V).	0.836
ADH4	ALDH3B2	ENSUAMP00000014759	ENSUAMP00000031679	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.894
ADH4	AOX1	ENSUAMP00000014759	ENSUAMP00000019809	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde oxidase 1.	0.920
ADH4	CYP2E1	ENSUAMP00000014759	ENSUAMP00000033866	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	0.877
ADH4	ENSUAMP00000001920	ENSUAMP00000014759	ENSUAMP00000001920	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.856
ADH4	ENSUAMP00000003052	ENSUAMP00000014759	ENSUAMP00000003052	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.873
ADH4	ENSUAMP00000003787	ENSUAMP00000014759	ENSUAMP00000003787	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.814
ADH4	ENSUAMP00000003802	ENSUAMP00000014759	ENSUAMP00000003802	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.873
ADH4	ENSUAMP00000004109	ENSUAMP00000014759	ENSUAMP00000004109	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.856
ADH4	ENSUAMP00000005458	ENSUAMP00000014759	ENSUAMP00000005458	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.914
ADH4	ENSUAMP00000006241	ENSUAMP00000014759	ENSUAMP00000006241	Alcohol dehydrogenase 4 (class II), pi polypeptide.	GST N-terminal domain-containing protein.	0.814
ADH4	ENSUAMP00000006430	ENSUAMP00000014759	ENSUAMP00000006430	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.814
ADH4	ENSUAMP00000008117	ENSUAMP00000014759	ENSUAMP00000008117	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.856
ADH4	ENSUAMP00000009040	ENSUAMP00000014759	ENSUAMP00000009040	Alcohol dehydrogenase 4 (class II), pi polypeptide.	GST N-terminal domain-containing protein.	0.878
ADH4	ENSUAMP00000009042	ENSUAMP00000014759	ENSUAMP00000009042	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.878
ADH4	ENSUAMP00000009044	ENSUAMP00000014759	ENSUAMP00000009044	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.906
ADH4	ENSUAMP00000011012	ENSUAMP00000014759	ENSUAMP00000011012	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldedh domain-containing protein.	0.902
ADH4	ENSUAMP00000012071	ENSUAMP00000014759	ENSUAMP00000012071	Alcohol dehydrogenase 4 (class II), pi polypeptide.	GST N-terminal domain-containing protein.	0.814
ADH4	ENSUAMP00000013015	ENSUAMP00000014759	ENSUAMP00000013015	Alcohol dehydrogenase 4 (class II), pi polypeptide.	DSBA domain-containing protein.	0.874
ADH4	ENSUAMP00000013421	ENSUAMP00000014759	ENSUAMP00000013421	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.850