STRINGSTRING
NME1 NME1 ENSUAMP00000013421 ENSUAMP00000013421 ENSUAMP00000013425 ENSUAMP00000013425 GSTT4 GSTT4 ENSUAMP00000013433 ENSUAMP00000013433 ENSUAMP00000013435 ENSUAMP00000013435 CDA CDA ENSUAMP00000014595 ENSUAMP00000014595 ENSUAMP00000015279 ENSUAMP00000015279 PUSL1 PUSL1 SPSB4 SPSB4 NME3 NME3 MRPS34 MRPS34 SPSB3 SPSB3 UCK2 UCK2 MGST3 MGST3 TPMT TPMT ENSUAMP00000018500 ENSUAMP00000018500 XDH XDH UPP1 UPP1 GMPS GMPS CES3 CES3 NME4 NME4 ENSUAMP00000020992 ENSUAMP00000020992 ENSUAMP00000021744 ENSUAMP00000021744 GDAP1L1 GDAP1L1 PUS1 PUS1 IMPDH2 IMPDH2 ENSUAMP00000022722 ENSUAMP00000022722 ENSUAMP00000023031 ENSUAMP00000023031 ENSUAMP00000024998 ENSUAMP00000024998 SLC12A1 SLC12A1 TK1 TK1 RRM2 RRM2 FBXL2 FBXL2 ENSUAMP00000028620 ENSUAMP00000028620 GDAP1 GDAP1 ENSUAMP00000028888 ENSUAMP00000028888 MGST2 MGST2 NME6 NME6 ENSUAMP00000031423 ENSUAMP00000031423 ENSUAMP00000031424 ENSUAMP00000031424 FBXO45 FBXO45 ENSUAMP00000032777 ENSUAMP00000032777 CYP2E1 CYP2E1 FBXL20 FBXL20 SPSB2 SPSB2 CES2 CES2 ENSUAMP00000006430 ENSUAMP00000006430 ENSUAMP00000006241 ENSUAMP00000006241 ENSUAMP00000005458 ENSUAMP00000005458 NME2 NME2 UPB1 UPB1 ENSUAMP00000004109 ENSUAMP00000004109 GSTM3 GSTM3 ENSUAMP00000003899 ENSUAMP00000003899 ENSUAMP00000003787 ENSUAMP00000003787 ENSUAMP00000003614 ENSUAMP00000003614 GSTO1 GSTO1 GSTO2 GSTO2 ENSUAMP00000001920 ENSUAMP00000001920 DUT DUT UCKL1 UCKL1 UMPS UMPS CES5A CES5A ENSUAMP00000035567 ENSUAMP00000035567 ENSUAMP00000035827 ENSUAMP00000035827 CMPK1 CMPK1 ENSUAMP00000007917 ENSUAMP00000007917 TK2 TK2 ENSUAMP00000008117 ENSUAMP00000008117 IMPDH1 IMPDH1 ENSUAMP00000009040 ENSUAMP00000009040 ENSUAMP00000009042 ENSUAMP00000009042 ENSUAMP00000009044 ENSUAMP00000009044 GSTA4 GSTA4 FAM78A FAM78A UCK1 UCK1 GUSB GUSB PUS3 PUS3 UGT1A1 UGT1A1 ENSUAMP00000012071 ENSUAMP00000012071 HPRT1 HPRT1 ITPA ITPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NME1Nucleoside diphosphate kinase. (152 aa)
ENSUAMP00000013421Uncharacterized protein. (240 aa)
ENSUAMP00000013425Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
ENSUAMP00000013433Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
ENSUAMP00000013435Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
ENSUAMP00000014595UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
ENSUAMP00000015279NDK domain-containing protein; Belongs to the NDK family. (181 aa)
PUSL1tRNA pseudouridine synthase. (301 aa)
SPSB4SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
NME3Nucleoside diphosphate kinase. (169 aa)
MRPS34Mitochondrial ribosomal protein S34. (219 aa)
SPSB3SplA/ryanodine receptor domain and SOCS box containing 3. (379 aa)
UCK2Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
TPMTThiopurine S-methyltransferase. (220 aa)
ENSUAMP00000018500Fer4_20 domain-containing protein. (166 aa)
XDHXanthine dehydrogenase. (1313 aa)
UPP1Uridine phosphorylase 1. (316 aa)
GMPSGuanine monophosphate synthase. (693 aa)
CES3Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (571 aa)
NME4Nucleoside diphosphate kinase. (187 aa)
ENSUAMP00000020992ATP-cone domain-containing protein. (123 aa)
ENSUAMP00000021744Uncharacterized protein. (353 aa)
GDAP1L1Ganglioside induced differentiation associated protein 1 like 1. (367 aa)
PUS1Pseudouridine synthase 1. (394 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
ENSUAMP00000022722Uncharacterized protein. (223 aa)
ENSUAMP00000023031Uncharacterized protein. (118 aa)
ENSUAMP00000024998NDK domain-containing protein. (144 aa)
SLC12A1Solute carrier family 12 member 1. (973 aa)
TK1Thymidine kinase. (239 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (297 aa)
FBXL2F-box and leucine rich repeat protein 2. (422 aa)
ENSUAMP00000028620Uncharacterized protein. (106 aa)
GDAP1Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (358 aa)
ENSUAMP00000028888NDK domain-containing protein; Belongs to the NDK family. (89 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
ENSUAMP00000031423Uncharacterized protein. (273 aa)
ENSUAMP00000031424B30.2/SPRY domain-containing protein. (268 aa)
FBXO45F-box protein 45. (303 aa)
ENSUAMP00000032777Uncharacterized protein. (323 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (494 aa)
FBXL20F-box and leucine rich repeat protein 20. (436 aa)
SPSB2SplA/ryanodine receptor domain and SOCS box containing 2. (263 aa)
CES2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
ENSUAMP00000006430Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
ENSUAMP00000006241GST N-terminal domain-containing protein. (60 aa)
ENSUAMP00000005458Uncharacterized protein. (51 aa)
NME2Nucleoside diphosphate kinase. (159 aa)
UPB1Beta-ureidopropionase 1. (384 aa)
ENSUAMP00000004109Uncharacterized protein; Belongs to the GST superfamily. (256 aa)
GSTM3Glutathione S-transferase. (226 aa)
ENSUAMP00000003899Uncharacterized protein; Belongs to the arylamine N-acetyltransferase family. (290 aa)
ENSUAMP00000003787Uncharacterized protein. (209 aa)
ENSUAMP00000003614Uncharacterized protein. (154 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (278 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
ENSUAMP00000001920Uncharacterized protein. (229 aa)
DUTDeoxyuridine triphosphatase. (175 aa)
UCKL1Uridine-cytidine kinase; Belongs to the uridine kinase family. (547 aa)
UMPSOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (302 aa)
CES5ACarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (552 aa)
ENSUAMP00000035567Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
ENSUAMP00000035827Uncharacterized protein. (175 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)
ENSUAMP00000007917Uncharacterized protein. (62 aa)
TK2Thymidine kinase 2. (216 aa)
ENSUAMP00000008117Uncharacterized protein. (230 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (609 aa)
ENSUAMP00000009040GST N-terminal domain-containing protein. (150 aa)
ENSUAMP00000009042Uncharacterized protein. (158 aa)
ENSUAMP00000009044Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (223 aa)
FAM78AFamily with sequence similarity 78 member A. (283 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (276 aa)
GUSBBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (648 aa)
PUS3Pseudouridine synthase 3. (480 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
ENSUAMP00000012071GST N-terminal domain-containing protein. (193 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (215 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (209 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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