STRINGSTRING
GPT GPT SDSL SDSL MAL2 MAL2 ENSUAMP00000002017 ENSUAMP00000002017 ENO3 ENO3 ENSUAMP00000002320 ENSUAMP00000002320 LGSN LGSN PSPH PSPH ENSUAMP00000003272 ENSUAMP00000003272 ENSUAMP00000003370 ENSUAMP00000003370 ENSUAMP00000003524 ENSUAMP00000003524 EPS8L3 EPS8L3 ENSUAMP00000005122 ENSUAMP00000005122 PGAM2 PGAM2 ENSUAMP00000005441 ENSUAMP00000005441 ENSUAMP00000005537 ENSUAMP00000005537 CRYM CRYM MAT2B MAT2B IDH3B IDH3B NAGS NAGS TKT TKT IDH2 IDH2 PC PC CTH CTH ENSUAMP00000010325 ENSUAMP00000010325 THNSL1 THNSL1 ENSUAMP00000011289 ENSUAMP00000011289 GOT2 GOT2 ENSUAMP00000011412 ENSUAMP00000011412 IDH1 IDH1 CMTM8 CMTM8 PSAT1 PSAT1 ARG2 ARG2 ENSUAMP00000012486 ENSUAMP00000012486 ENSUAMP00000012599 ENSUAMP00000012599 PGAM1 PGAM1 MYCBPAP MYCBPAP BCAT2 BCAT2 HSD17B14 HSD17B14 PFKM PFKM SHMT1 SHMT1 ASNS ASNS ENSUAMP00000014143 ENSUAMP00000014143 ENSUAMP00000014171 ENSUAMP00000014171 ENSUAMP00000014177 ENSUAMP00000014177 PRPSAP2 PRPSAP2 NOXRED1 NOXRED1 TMED8 TMED8 ENSUAMP00000014859 ENSUAMP00000014859 WRAP73 WRAP73 DIMT1 DIMT1 MAT1A MAT1A PYCR3 PYCR3 METTL1 METTL1 ALDOC ALDOC SPAG5 SPAG5 ENSUAMP00000018361 ENSUAMP00000018361 ENSUAMP00000019211 ENSUAMP00000019211 TKTL2 TKTL2 ENSUAMP00000019947 ENSUAMP00000019947 MYADM MYADM IDH3G IDH3G GPT2 GPT2 PAH PAH SRFBP1 SRFBP1 PYCR1 PYCR1 PLLP PLLP EPS8L1 EPS8L1 PFKP PFKP TFB1M TFB1M PRPS1 PRPS1 PARP8 PARP8 ENSUAMP00000023215 ENSUAMP00000023215 IDH3A IDH3A MTR MTR ENSUAMP00000024190 ENSUAMP00000024190 ENSUAMP00000024191 ENSUAMP00000024191 ENSUAMP00000024225 ENSUAMP00000024225 ENSUAMP00000024226 ENSUAMP00000024226 CMTM2 CMTM2 ENSUAMP00000024228 ENSUAMP00000024228 ENSUAMP00000024229 ENSUAMP00000024229 THNSL2 THNSL2 PNPLA8 PNPLA8 MAL MAL MALL MALL ENO4 ENO4 TKTL1 TKTL1 PKLR PKLR ACO1 ACO1 ENSUAMP00000026965 ENSUAMP00000026965 SHMT2 SHMT2 ALDOB ALDOB ENSUAMP00000027384 ENSUAMP00000027384 PGK1 PGK1 ALDH18A1 ALDH18A1 RPIA RPIA TALDO1 TALDO1 EPS8L2 EPS8L2 GAPDH GAPDH PRPSAP1 PRPSAP1 ACO2 ACO2 EIF2D EIF2D ARG1 ARG1 ENSUAMP00000030469 ENSUAMP00000030469 GOT1L1 GOT1L1 OTC OTC PGK2 PGK2 ENSUAMP00000031432 ENSUAMP00000031432 ENSUAMP00000031500 ENSUAMP00000031500 ENSUAMP00000031501 ENSUAMP00000031501 GOT1 GOT1 ENSUAMP00000031664 ENSUAMP00000031664 CMTM5 CMTM5 MYADML2 MYADML2 PFKL PFKL PHGDH PHGDH GLUL GLUL CPS1 CPS1 ENSUAMP00000033138 ENSUAMP00000033138 ENSUAMP00000033767 ENSUAMP00000033767 PARP6 PARP6 PKM PKM ENSUAMP00000034037 ENSUAMP00000034037 PRPS2 PRPS2 CS CS TPI1 TPI1 ENO2 ENO2 ENSUAMP00000035932 ENSUAMP00000035932 MAT2A MAT2A ENSUAMP00000036881 ENSUAMP00000036881 CMTM6 CMTM6 SDS SDS ENSUAMP00000037561 ENSUAMP00000037561
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPTGlutamic--pyruvic transaminase. (622 aa)
SDSLSerine dehydratase like. (329 aa)
MAL2MARVEL domain-containing protein. (176 aa)
ENSUAMP00000002017Gp_dh_N domain-containing protein. (243 aa)
ENO3Enolase 3. (445 aa)
ENSUAMP00000002320Gp_dh_C domain-containing protein. (118 aa)
LGSNLengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (509 aa)
PSPHPhosphoserine phosphatase. (225 aa)
ENSUAMP00000003272SHMT domain-containing protein. (59 aa)
ENSUAMP00000003370MARVEL domain-containing protein. (170 aa)
ENSUAMP00000003524PFK domain-containing protein. (53 aa)
EPS8L3EPS8 like 3. (601 aa)
ENSUAMP00000005122Gp_dh_C domain-containing protein. (84 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
ENSUAMP00000005441Uncharacterized protein. (80 aa)
ENSUAMP00000005537Uncharacterized protein. (246 aa)
CRYMCrystallin mu. (314 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (324 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
NAGSN-acetylglutamate synthase. (523 aa)
TKTTransketolase. (623 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (421 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1190 aa)
CTHCystathionine gamma-lyase. (409 aa)
ENSUAMP00000010325Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (193 aa)
THNSL1Threonine synthase like 1. (743 aa)
ENSUAMP00000011289Uncharacterized protein. (495 aa)
GOT2Aspartate aminotransferase. (393 aa)
ENSUAMP00000011412rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (290 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
CMTM8CKLF like MARVEL transmembrane domain containing 8. (100 aa)
PSAT1Phosphoserine aminotransferase. (334 aa)
ARG2Arginase. (354 aa)
ENSUAMP00000012486Uncharacterized protein. (314 aa)
ENSUAMP00000012599Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (573 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
MYCBPAPMYCBP associated protein. (999 aa)
BCAT2Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (463 aa)
HSD17B14Hydroxysteroid 17-beta dehydrogenase 14. (336 aa)
PFKMUncharacterized protein. (862 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
ENSUAMP00000014143Uncharacterized protein. (157 aa)
ENSUAMP00000014171PFK domain-containing protein. (309 aa)
ENSUAMP00000014177Glutamine amidotransferase type-2 domain-containing protein. (644 aa)
PRPSAP2Phosphoribosyl pyrophosphate synthetase associated protein 2. (375 aa)
NOXRED1NADP dependent oxidoreductase domain containing 1. (329 aa)
TMED8Transmembrane p24 trafficking protein family member 8. (332 aa)
ENSUAMP00000014859Iso_dh domain-containing protein. (372 aa)
WRAP73WD repeat containing, antisense to TP73. (460 aa)
DIMT1rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (313 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
PYCR3Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (276 aa)
METTL1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (277 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
SPAG5Sperm associated antigen 5. (720 aa)
ENSUAMP00000018361Uncharacterized protein. (168 aa)
ENSUAMP00000019211MARVEL domain-containing protein. (136 aa)
TKTL2Transketolase like 2. (626 aa)
ENSUAMP00000019947Uncharacterized protein. (147 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (395 aa)
GPT2Glutamic--pyruvic transaminase 2. (559 aa)
PAHPhenylalanine hydroxylase. (409 aa)
SRFBP1Serum response factor binding protein 1. (412 aa)
PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
PLLPMARVEL domain-containing protein. (182 aa)
EPS8L1EPS8 like 1. (717 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (803 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (351 aa)
PRPS1Uncharacterized protein. (197 aa)
PARP8Poly [ADP-ribose] polymerase. (515 aa)
ENSUAMP00000023215Uncharacterized protein. (59 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (380 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa)
ENSUAMP00000024190Uncharacterized protein. (147 aa)
ENSUAMP00000024191Uncharacterized protein. (57 aa)
ENSUAMP00000024225Uncharacterized protein. (95 aa)
ENSUAMP00000024226MARVEL domain-containing protein. (261 aa)
CMTM2CKLF like MARVEL transmembrane domain containing 2. (208 aa)
ENSUAMP00000024228MARVEL domain-containing protein. (96 aa)
ENSUAMP00000024229MARVEL domain-containing protein. (177 aa)
THNSL2Threonine synthase like 2. (435 aa)
PNPLA8Patatin like phospholipase domain containing 8. (780 aa)
MALMal, T cell differentiation protein. (144 aa)
MALLMal, T cell differentiation protein like. (145 aa)
ENO4Enolase 4. (625 aa)
TKTL1Transketolase like 1. (616 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (563 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
ENSUAMP00000026965M20_dimer domain-containing protein. (408 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (328 aa)
ENSUAMP00000027384Beta_elim_lyase domain-containing protein. (401 aa)
PGK1Phosphoglycerate kinase. (417 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
RPIARibose 5-phosphate isomerase A. (286 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
EPS8L2EPS8 like 2. (649 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (347 aa)
PRPSAP1Phosphoribosyl pyrophosphate synthetase associated protein 1. (385 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (799 aa)
EIF2DEukaryotic translation initiation factor 2D. (586 aa)
ARG1Arginase. (322 aa)
ENSUAMP00000030469AAA domain-containing protein; Belongs to the AAA ATPase family. (303 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (406 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
PGK2Phosphoglycerate kinase. (297 aa)
ENSUAMP00000031432Uncharacterized protein. (304 aa)
ENSUAMP00000031500Uncharacterized protein. (89 aa)
ENSUAMP00000031501Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
GOT1Aspartate aminotransferase. (413 aa)
ENSUAMP00000031664annotation not available (372 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5. (156 aa)
MYADML2Myeloid associated differentiation marker like 2. (307 aa)
PFKLPhosphofructokinase, liver type. (577 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
GLULGlutamine synthetase. (484 aa)
CPS1Carbamoyl-phosphate synthase 1. (994 aa)
ENSUAMP00000033138Uncharacterized protein. (153 aa)
ENSUAMP00000033767Uncharacterized protein. (60 aa)
PARP6Poly [ADP-ribose] polymerase. (610 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
ENSUAMP00000034037SH3 domain-containing protein. (437 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (294 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
TPI1Triosephosphate isomerase. (249 aa)
ENO2Enolase 2. (434 aa)
ENSUAMP00000035932Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (172 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
ENSUAMP00000036881MARVEL domain-containing protein. (274 aa)
CMTM6CKLF like MARVEL transmembrane domain containing 6. (171 aa)
SDSSerine dehydratase. (328 aa)
ENSUAMP00000037561Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (374 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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