STRINGSTRING
ENSUAMP00000009272 ENSUAMP00000009272 ENSUAMP00000000785 ENSUAMP00000000785 TP53 TP53 DLL3 DLL3 CEP152 CEP152 ENSUAMP00000003258 ENSUAMP00000003258 ENSUAMP00000003693 ENSUAMP00000003693 E2F2 E2F2 ADCY9 ADCY9 ESR1 ESR1 RPS6KB2 RPS6KB2 CARM1 CARM1 CDKN1B CDKN1B ADCY2 ADCY2 ADCY3 ADCY3 JUN JUN PIK3CA PIK3CA MAPK8 MAPK8 ENSUAMP00000010013 ENSUAMP00000010013 PIK3R1 PIK3R1 AKT1 AKT1 ERBB2 ERBB2 AKT3 AKT3 BCL2 BCL2 GRB2 GRB2 BAX BAX MAPK1 MAPK1 ERAS ERAS SP1 SP1 JAG2 JAG2 ENSUAMP00000014949 ENSUAMP00000014949 RB1 RB1 IGF1R IGF1R SOS2 SOS2 ENSUAMP00000015993 ENSUAMP00000015993 CDK4 CDK4 ENSUAMP00000016793 ENSUAMP00000016793 MAPK12 MAPK12 MAPK11 MAPK11 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 SHC1 SHC1 BAD BAD PPP1R14B PPP1R14B MTOR MTOR PIK3CD PIK3CD NOTCH4 NOTCH4 GPSM3 GPSM3 KRAS KRAS MMP20 MMP20 DLL4 DLL4 IGF1 IGF1 ENSUAMP00000021380 ENSUAMP00000021380 ENSUAMP00000021381 ENSUAMP00000021381 ENSUAMP00000022131 ENSUAMP00000022131 RPS6KB1 RPS6KB1 MAPK10 MAPK10 MDM2 MDM2 BRAF BRAF ABCB11 ABCB11 NCOA3 NCOA3 NCOR1 NCOR1 ENSUAMP00000025261 ENSUAMP00000025261 CDKN2C CDKN2C ENSUAMP00000026030 ENSUAMP00000026030 ENSUAMP00000026993 ENSUAMP00000026993 ENSUAMP00000027431 ENSUAMP00000027431 ADCY5 ADCY5 ENSUAMP00000027945 ENSUAMP00000027945 ADCY1 ADCY1 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 GNAS GNAS CDKN1A CDKN1A MMP9 MMP9 MAPK9 MAPK9 DLL1 DLL1 ENSUAMP00000029031 ENSUAMP00000029031 SRC SRC ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 RAF1 RAF1 ENSUAMP00000030787 ENSUAMP00000030787 ENSUAMP00000030830 ENSUAMP00000030830 HBEGF HBEGF PTK2 PTK2 MAPK3 MAPK3 ENSUAMP00000031719 ENSUAMP00000031719 ADCY4 ADCY4 MAPK14 MAPK14 MAPK13 MAPK13 ADCY7 ADCY7 CCND1 CCND1 ENSUAMP00000032618 ENSUAMP00000032618 SOS1 SOS1 ENSUAMP00000032909 ENSUAMP00000032909 PRKACB PRKACB NOTCH2 NOTCH2 MMP2 MMP2 MED1 MED1 NOTCH1 NOTCH1 JAG1 JAG1 E2F1 E2F1 E2F3 E2F3 GPER1 GPER1 ENSUAMP00000035331 ENSUAMP00000035331 ADCY6 ADCY6 ENSUAMP00000036162 ENSUAMP00000036162 ENSUAMP00000036324 ENSUAMP00000036324 NOTCH3 NOTCH3 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000009272Uncharacterized protein. (146 aa)
ENSUAMP00000000785SH2 domain-containing protein. (91 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
DLL3Delta like canonical Notch ligand 3. (565 aa)
CEP152Centrosomal protein 152. (1716 aa)
ENSUAMP00000003258Uncharacterized protein. (246 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
E2F2E2F transcription factor 2. (431 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ESR1Estrogen receptor 1. (490 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (636 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERASES cell expressed Ras. (219 aa)
SP1Sp1 transcription factor. (780 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1197 aa)
ENSUAMP00000014949FERM domain-containing protein. (121 aa)
RB1RB transcriptional corepressor 1. (870 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
SHC1SHC adaptor protein 1. (474 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
NOTCH4Notch receptor 4. (1894 aa)
GPSM3G protein signaling modulator 3. (157 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
IGF1Insulin like growth factor 1. (171 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
ABCB11ATP binding cassette subfamily B member 11. (1319 aa)
NCOA3Nuclear receptor coactivator. (1431 aa)
NCOR1Nuclear receptor corepressor 1. (2267 aa)
ENSUAMP00000025261GPS2_interact domain-containing protein. (204 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ENSUAMP00000027945Uncharacterized protein. (545 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
GNASGNAS complex locus. (994 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
SRCTyrosine-protein kinase. (557 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
ENSUAMP00000030830Uncharacterized protein. (290 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PTK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (976 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
NOTCH2Notch receptor 2. (2374 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
NOTCH1Notch receptor 1. (2547 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
E2F1E2F transcription factor 1. (400 aa)
E2F3E2F transcription factor 3. (469 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
NOTCH3Notch receptor 3. (2291 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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