STRINGSTRING
ENSUAMP00000017692 ENSUAMP00000017692 MSH6 MSH6 MSH2 MSH2 ENSUAMP00000018011 ENSUAMP00000018011 ENSUAMP00000018082 ENSUAMP00000018082 BIRC2 BIRC2 BIRC3 BIRC3 BAD BAD PPP1R14B PPP1R14B PIK3CD PIK3CD CASP3 CASP3 REV3L REV3L ENSUAMP00000022131 ENSUAMP00000022131 CASP9 CASP9 ENSUAMP00000022738 ENSUAMP00000022738 SLC31A1 SLC31A1 MDM2 MDM2 APAF1 APAF1 ERCC1 ERCC1 BIRC5 BIRC5 ENSUAMP00000027431 ENSUAMP00000027431 FADD FADD ATP7A ATP7A CDKN1A CDKN1A CYCS CYCS C7orf31 C7orf31 MGST2 MGST2 BCL2L1 BCL2L1 MAPK3 MAPK3 ABCC2 ABCC2 ENSUAMP00000033611 ENSUAMP00000033611 ENSUAMP00000035027 ENSUAMP00000035027 ENSUAMP00000035331 ENSUAMP00000035331 PMAIP1 PMAIP1 MLH1 MLH1 AKT2 AKT2 ENSUAMP00000008823 ENSUAMP00000008823 ENSUAMP00000009040 ENSUAMP00000009040 ENSUAMP00000009042 ENSUAMP00000009042 ENSUAMP00000009044 ENSUAMP00000009044 GSTA4 GSTA4 PIK3CA PIK3CA MAPK1 MAPK1 PIK3R1 PIK3R1 AKT1 AKT1 ERBB2 ERBB2 AKT3 AKT3 BCL2 BCL2 ENSUAMP00000012071 ENSUAMP00000012071 BAX BAX BID BID ENSUAMP00000013421 ENSUAMP00000013421 ENSUAMP00000013425 ENSUAMP00000013425 GSTT4 GSTT4 ENSUAMP00000013433 ENSUAMP00000013433 ENSUAMP00000013435 ENSUAMP00000013435 BAK1 BAK1 TOP2A TOP2A TP53 TP53 ENSUAMP00000001920 ENSUAMP00000001920 GSTO2 GSTO2 GSTO1 GSTO1 XIAP XIAP ENSUAMP00000003787 ENSUAMP00000003787 GSTM3 GSTM3 ENSUAMP00000004109 ENSUAMP00000004109 ENSUAMP00000004964 ENSUAMP00000004964 ENSUAMP00000005458 ENSUAMP00000005458 XPA XPA ENSUAMP00000006241 ENSUAMP00000006241 ENSUAMP00000006430 ENSUAMP00000006430 ENSUAMP00000007328 ENSUAMP00000007328 MAP3K5 MAP3K5 CASP8 CASP8 ENSUAMP00000008117 ENSUAMP00000008117 TOP2B TOP2B ENSUAMP00000016311 ENSUAMP00000016311 PDPK1 PDPK1 ENSUAMP00000016504 ENSUAMP00000016504 MGST3 MGST3 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017619 ENSUAMP00000017619
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000017692Uncharacterized protein. (704 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1260 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
ENSUAMP00000018011Uncharacterized protein. (275 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (2648 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
ENSUAMP00000022738Uncharacterized protein. (126 aa)
SLC31A1Solute carrier family 31 member 1. (178 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
APAF1Apoptotic peptidase activating factor 1. (948 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
C7orf31Chromosome 7 open reading frame 31. (575 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
BCL2L1BCL2 like 1. (233 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ABCC2ATP binding cassette subfamily C member 2. (1541 aa)
ENSUAMP00000033611UmuC domain-containing protein. (188 aa)
ENSUAMP00000035027Uncharacterized protein. (146 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
MLH1MutL homolog 1. (758 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
ENSUAMP00000009040GST N-terminal domain-containing protein. (150 aa)
ENSUAMP00000009042Uncharacterized protein. (158 aa)
ENSUAMP00000009044Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (223 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
ENSUAMP00000012071GST N-terminal domain-containing protein. (193 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (196 aa)
ENSUAMP00000013421Uncharacterized protein. (240 aa)
ENSUAMP00000013425Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
ENSUAMP00000013433Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
ENSUAMP00000013435Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1505 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000001920Uncharacterized protein. (229 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (278 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
ENSUAMP00000003787Uncharacterized protein. (209 aa)
GSTM3Glutathione S-transferase. (226 aa)
ENSUAMP00000004109Uncharacterized protein; Belongs to the GST superfamily. (256 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
ENSUAMP00000005458Uncharacterized protein. (51 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
ENSUAMP00000006241GST N-terminal domain-containing protein. (60 aa)
ENSUAMP00000006430Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
ENSUAMP00000007328DNA_MISMATCH_REPAIR_2 domain-containing protein. (366 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1212 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
ENSUAMP00000008117Uncharacterized protein. (230 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1539 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ENSUAMP00000016504BRCT domain-containing protein. (101 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017619UmuC domain-containing protein. (558 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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