(80 nodes) DNA replication network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RNASEH2B	Ribonuclease H2 subunit B. (296 aa)
	ENSUAMP00000029458	Poly [ADP-ribose] polymerase. (359 aa)
	PARP9	Poly(ADP-ribose) polymerase family member 9. (827 aa)
	ENSUAMP00000028972	Uncharacterized protein. (262 aa)
	ENSUAMP00000028130	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
	ENSUAMP00000028112	CBFD_NFYB_HMF domain-containing protein. (55 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (903 aa)
	TOR4A	Torsin family 4 member A. (422 aa)
	RNASEH2C	Ribonuclease H2 subunit C. (171 aa)
	CPNE7	Copine 7. (637 aa)
	RFC3	Replication factor C subunit 3. (185 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (340 aa)
	CPNE2	Copine 2. (548 aa)
	TOR1A	Torsin. (332 aa)
	TOR1B	Torsin. (336 aa)
	YJU2	YJU2 splicing factor homolog. (298 aa)
	ENSUAMP00000024458	Uncharacterized protein. (155 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (808 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	ENSUAMP00000023282	RNase H domain-containing protein. (193 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (863 aa)
	ENSUAMP00000022046	RFC1 domain-containing protein. (138 aa)
	MCM6	Minichromosome maintenance complex component 6; Belongs to the MCM family. (451 aa)
	ENSUAMP00000021352	Uncharacterized protein. (141 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	ENSUAMP00000020174	Uncharacterized protein. (91 aa)
	C16orf70	Chromosome 16 open reading frame 70. (422 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (734 aa)
	MACROD1	Mono-ADP ribosylhydrolase 1. (328 aa)
	POLD1	DNA polymerase. (1109 aa)
	SSBP1	Single stranded DNA binding protein 1. (143 aa)
	GTF3C6	General transcription factor IIIC subunit 6. (239 aa)
	ENSUAMP00000016108	Uncharacterized protein. (92 aa)
	FAM162B	Family with sequence similarity 162 member B. (163 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	PRKRIP1	PRKR interacting protein 1. (187 aa)
	ENSUAMP00000013972	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (163 aa)
	CPNE9	Copine family member 9. (547 aa)
	ENSUAMP00000013559	Uncharacterized protein. (126 aa)
	CPNE1	Copine 1. (596 aa)
	EXOC8	Exocyst complex component 8. (721 aa)
	ENSUAMP00000011763	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (295 aa)
	ENSUAMP00000011742	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (667 aa)
	ENSUAMP00000011715	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (404 aa)
	ENSUAMP00000011011	Uncharacterized protein. (465 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
	LIG1	DNA ligase. (915 aa)
	ENSUAMP00000007940	Uncharacterized protein. (557 aa)
	ENSUAMP00000007930	Uncharacterized protein. (115 aa)
	ENSUAMP00000007405	Uncharacterized protein. (485 aa)
	ENSUAMP00000006705	Uncharacterized protein. (266 aa)
	ENSUAMP00000001303	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (578 aa)
	ENSUAMP00000000649	Copine domain-containing protein. (108 aa)
	WRNIP1	WRN helicase interacting protein 1. (663 aa)
	CPNE5	Copine 5. (593 aa)
	CABP5	Calcium binding protein 5. (173 aa)
	CPNE3	Copine 3. (522 aa)
	TOR3A	Torsin family 3 member A. (394 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	ENSUAMP00000004516	Uncharacterized protein. (287 aa)
	ENSUAMP00000004504	Poly [ADP-ribose] polymerase. (382 aa)
	SASS6	SAS-6 centriolar assembly protein. (617 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (507 aa)
	ENSUAMP00000003214	Uncharacterized protein. (116 aa)
	ENSUAMP00000002089	XPGI domain-containing protein. (335 aa)
	ENSUAMP00000001912	Uncharacterized protein. (168 aa)
	ENSUAMP00000037532	Uncharacterized protein. (209 aa)
	STN1	STN1 subunit of CST complex. (285 aa)
	RFC5	Replication factor C subunit 5. (255 aa)
	RFC2	Replication factor C subunit 2. (368 aa)
	ENSUAMP00000031944	Uncharacterized protein. (79 aa)
	ENSUAMP00000031776	Uncharacterized protein. (122 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (115 aa)
	CPNE6	Copine 6. (560 aa)
	TOR2A	Torsin. (321 aa)
	ENSUAMP00000031071	Replication factor C subunit 1. (1147 aa)
	MCMDC2	Minichromosome maintenance domain containing 2. (681 aa)
	GDAP2	Ganglioside induced differentiation associated protein 2. (495 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPNE1	RNASEH2A	ENSUAMP00000012863	ENSUAMP00000025147	Copine 1.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
CPNE1	RNASEH2B	ENSUAMP00000012863	ENSUAMP00000029704	Copine 1.	Ribonuclease H2 subunit B.	0.507
CPNE1	TOR4A	ENSUAMP00000012863	ENSUAMP00000027780	Copine 1.	Torsin family 4 member A.	0.524
CPNE2	PRKRIP1	ENSUAMP00000025000	ENSUAMP00000014065	Copine 2.	PRKR interacting protein 1.	0.743
CPNE2	RNASEH2A	ENSUAMP00000025000	ENSUAMP00000025147	Copine 2.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
CPNE2	RNASEH2B	ENSUAMP00000025000	ENSUAMP00000029704	Copine 2.	Ribonuclease H2 subunit B.	0.507
CPNE3	RNASEH2A	ENSUAMP00000005724	ENSUAMP00000025147	Copine 3.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
CPNE3	RNASEH2B	ENSUAMP00000005724	ENSUAMP00000029704	Copine 3.	Ribonuclease H2 subunit B.	0.507
CPNE5	RNASEH2A	ENSUAMP00000000195	ENSUAMP00000025147	Copine 5.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
CPNE5	RNASEH2B	ENSUAMP00000000195	ENSUAMP00000029704	Copine 5.	Ribonuclease H2 subunit B.	0.507
CPNE6	RNASEH2A	ENSUAMP00000031306	ENSUAMP00000025147	Copine 6.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
CPNE6	RNASEH2B	ENSUAMP00000031306	ENSUAMP00000029704	Copine 6.	Ribonuclease H2 subunit B.	0.507
CPNE7	RNASEH2A	ENSUAMP00000026253	ENSUAMP00000025147	Copine 7.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
CPNE7	RNASEH2B	ENSUAMP00000026253	ENSUAMP00000029704	Copine 7.	Ribonuclease H2 subunit B.	0.507
CPNE9	RNASEH2A	ENSUAMP00000013596	ENSUAMP00000025147	Copine family member 9.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
CPNE9	RNASEH2B	ENSUAMP00000013596	ENSUAMP00000029704	Copine family member 9.	Ribonuclease H2 subunit B.	0.507
ENSUAMP00000000649	RNASEH2A	ENSUAMP00000000649	ENSUAMP00000025147	Copine domain-containing protein.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.455
ENSUAMP00000000649	RNASEH2B	ENSUAMP00000000649	ENSUAMP00000029704	Copine domain-containing protein.	Ribonuclease H2 subunit B.	0.507
ENSUAMP00000001303	ENSUAMP00000001912	ENSUAMP00000001303	ENSUAMP00000001912	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	Uncharacterized protein.	0.694
ENSUAMP00000001303	ENSUAMP00000002089	ENSUAMP00000001303	ENSUAMP00000002089	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	XPGI domain-containing protein.	0.645