(65 nodes) Proteasome network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMB5	Proteasome subunit beta. (263 aa)
	ENSUAMP00000037175	MPN domain-containing protein. (156 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	ENSUAMP00000036637	PCI domain-containing protein. (405 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (344 aa)
	GTSF1L	Gametocyte specific factor 1 like. (154 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMA7	Proteasome endopeptidase complex. (248 aa)
	KIAA2012	KIAA2012. (1131 aa)
	PSME2	Proteasome activator subunit 2. (239 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
	ENSUAMP00000029591	Uncharacterized protein. (70 aa)
	GTSF1	Gametocyte specific factor 1. (186 aa)
	ENSUAMP00000028030	Uncharacterized protein. (109 aa)
	MORF4L1	Mortality factor 4 like 1. (235 aa)
	PSMB10	Proteasome subunit beta 10. (327 aa)
	ENSUAMP00000026056	MitMem_reg domain-containing protein. (95 aa)
	POMP	Proteasome maturation protein. (141 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	ENSUAMP00000024291	Uncharacterized protein. (76 aa)
	C12orf66	Chromosome 12 open reading frame 66. (320 aa)
	MORF4L2	Mortality factor 4 like 2. (288 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	ENSUAMP00000022022	Uncharacterized protein. (107 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (536 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (351 aa)
	PSMB9	Proteasome subunit beta. (220 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (376 aa)
	PSME3	Proteasome activator subunit 3. (254 aa)
	OSBPL1A	Oxysterol-binding protein; Belongs to the OSBP family. (856 aa)
	ENSUAMP00000013750	ARID domain-containing protein. (330 aa)
	ENSUAMP00000012220	ATPase_AAA_core domain-containing protein. (174 aa)
	NAA25	N(alpha)-acetyltransferase 25, NatB auxiliary subunit. (706 aa)
	PSMD9	PDZ domain-containing protein. (309 aa)
	ENSUAMP00000010612	WD_REPEATS_REGION domain-containing protein. (457 aa)
	ENSUAMP00000010607	Uncharacterized protein. (333 aa)
	ENSUAMP00000010270	Uncharacterized protein. (102 aa)
	PSME4	Proteasome activator subunit 4. (1436 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (322 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	ENSUAMP00000008157	Oxysterol-binding protein; Belongs to the OSBP family. (761 aa)
	ENSUAMP00000008156	Uncharacterized protein. (93 aa)
	PSMF1	Proteasome inhibitor subunit 1. (271 aa)
	PSMB11	Proteasome subunit beta. (292 aa)
	PSMB3	Proteasome subunit beta. (202 aa)
	PSMB6	Proteasome subunit beta. (219 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
	ENSUAMP00000005735	PROTEASOME_ALPHA_1 domain-containing protein. (80 aa)
	ENSUAMP00000004531	AAA domain-containing protein; Belongs to the AAA ATPase family. (421 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	ENSUAMP00000003372	Uncharacterized protein. (157 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (418 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (683 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (400 aa)
	PSMB2	Proteasome subunit beta. (167 aa)
	MSL3	MSL complex subunit 3. (448 aa)
	ENSUAMP00000000292	PCI domain-containing protein. (389 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000000292	ENSUAMP00000003372	ENSUAMP00000000292	ENSUAMP00000003372	PCI domain-containing protein.	Uncharacterized protein.	0.971
ENSUAMP00000000292	ENSUAMP00000004531	ENSUAMP00000000292	ENSUAMP00000004531	PCI domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.978
ENSUAMP00000000292	ENSUAMP00000005735	ENSUAMP00000000292	ENSUAMP00000005735	PCI domain-containing protein.	PROTEASOME_ALPHA_1 domain-containing protein.	0.954
ENSUAMP00000000292	ENSUAMP00000008157	ENSUAMP00000000292	ENSUAMP00000008157	PCI domain-containing protein.	Oxysterol-binding protein; Belongs to the OSBP family.	0.972
ENSUAMP00000000292	ENSUAMP00000012220	ENSUAMP00000000292	ENSUAMP00000012220	PCI domain-containing protein.	ATPase_AAA_core domain-containing protein.	0.978
ENSUAMP00000000292	ENSUAMP00000022022	ENSUAMP00000000292	ENSUAMP00000022022	PCI domain-containing protein.	Uncharacterized protein.	0.933
ENSUAMP00000000292	ENSUAMP00000026056	ENSUAMP00000000292	ENSUAMP00000026056	PCI domain-containing protein.	MitMem_reg domain-containing protein.	0.985
ENSUAMP00000000292	ENSUAMP00000029591	ENSUAMP00000000292	ENSUAMP00000029591	PCI domain-containing protein.	Uncharacterized protein.	0.910
ENSUAMP00000000292	ENSUAMP00000037175	ENSUAMP00000000292	ENSUAMP00000037175	PCI domain-containing protein.	MPN domain-containing protein.	0.985
ENSUAMP00000000292	KIAA2012	ENSUAMP00000000292	ENSUAMP00000032916	PCI domain-containing protein.	KIAA2012.	0.916
ENSUAMP00000000292	PSMA1	ENSUAMP00000000292	ENSUAMP00000025485	PCI domain-containing protein.	Proteasome subunit alpha type.	0.990
ENSUAMP00000000292	PSMA2	ENSUAMP00000000292	ENSUAMP00000033970	PCI domain-containing protein.	Proteasome subunit alpha type.	0.971
ENSUAMP00000000292	PSMA3	ENSUAMP00000000292	ENSUAMP00000009230	PCI domain-containing protein.	Proteasome subunit alpha type.	0.966
ENSUAMP00000000292	PSMA4	ENSUAMP00000000292	ENSUAMP00000022810	PCI domain-containing protein.	Proteasome subunit alpha type.	0.979
ENSUAMP00000000292	PSMA6	ENSUAMP00000000292	ENSUAMP00000030570	PCI domain-containing protein.	Proteasome subunit alpha type.	0.982
ENSUAMP00000000292	PSMA7	ENSUAMP00000000292	ENSUAMP00000033181	PCI domain-containing protein.	Proteasome endopeptidase complex.	0.976
ENSUAMP00000000292	PSMB1	ENSUAMP00000000292	ENSUAMP00000003646	PCI domain-containing protein.	Proteasome subunit beta.	0.991
ENSUAMP00000000292	PSMB10	ENSUAMP00000000292	ENSUAMP00000026793	PCI domain-containing protein.	Proteasome subunit beta 10.	0.940
ENSUAMP00000000292	PSMB11	ENSUAMP00000000292	ENSUAMP00000007268	PCI domain-containing protein.	Proteasome subunit beta.	0.890
ENSUAMP00000000292	PSMB2	ENSUAMP00000000292	ENSUAMP00000001276	PCI domain-containing protein.	Proteasome subunit beta.	0.986