STRINGSTRING
APOC3 APOC3 APOA1 APOA1 SIK3 SIK3 PCK1 PCK1 ENSUAMP00000025327 ENSUAMP00000025327 ENSUAMP00000025004 ENSUAMP00000025004 FABP1 FABP1 ANKRD24 ANKRD24 PLIN4 PLIN4 PLIN5 PLIN5 SCD SCD ACSL1 ACSL1 FABP3 FABP3 OLR1 OLR1 LPL LPL ACSBG1 ACSBG1 CYP8B1 CYP8B1 UCP2 UCP2 UCP3 UCP3 MMP1 MMP1 ENSUAMP00000021598 ENSUAMP00000021598 ACSL3 ACSL3 MMP8 MMP8 SCP2 SCP2 ADIPOQ ADIPOQ ENSUAMP00000019436 ENSUAMP00000019436 ENSUAMP00000019433 ENSUAMP00000019433 ENSUAMP00000019124 ENSUAMP00000019124 ENSUAMP00000019082 ENSUAMP00000019082 ENSUAMP00000018915 ENSUAMP00000018915 ENSUAMP00000018783 ENSUAMP00000018783 PLIN3 PLIN3 PPARD PPARD ENSUAMP00000017426 ENSUAMP00000017426 ME1 ME1 PDPK1 PDPK1 ENSUAMP00000015938 ENSUAMP00000015938 ACADM ACADM ACOX3 ACOX3 UCP1 UCP1 PLTP PLTP ENSUAMP00000012555 ENSUAMP00000012555 FABP4 FABP4 FABP9 FABP9 PMP2 PMP2 ENSUAMP00000012166 ENSUAMP00000012166 NR1I2 NR1I2 CPT2 CPT2 ENSUAMP00000011703 ENSUAMP00000011703 ENSUAMP00000011619 ENSUAMP00000011619 ENSUAMP00000011425 ENSUAMP00000011425 PPARA PPARA ACADL ACADL HMGCS1 HMGCS1 ENSUAMP00000010243 ENSUAMP00000010243 ENSUAMP00000009785 ENSUAMP00000009785 ENSUAMP00000008973 ENSUAMP00000008973 CPT1C CPT1C PKIB PKIB FABP7 FABP7 ANGPTL4 ANGPTL4 ENSUAMP00000006936 ENSUAMP00000006936 FABP12 FABP12 ACAA1 ACAA1 ENSUAMP00000004668 ENSUAMP00000004668 ENSUAMP00000004665 ENSUAMP00000004665 ACOX1 ACOX1 NR1H3 NR1H3 ACBD7 ACBD7 PPARG PPARG FADS3 FADS3 ENSUAMP00000002211 ENSUAMP00000002211 CPT1B CPT1B PLIN2 PLIN2 ENSUAMP00000001923 ENSUAMP00000001923 SLC27A1 SLC27A1 ACSBG2 ACSBG2 ENSUAMP00000001197 ENSUAMP00000001197 ENSUAMP00000001167 ENSUAMP00000001167 FABP2 FABP2 ENSUAMP00000000674 ENSUAMP00000000674 ENSUAMP00000037358 ENSUAMP00000037358 SLC27A6 SLC27A6 ACSL4 ACSL4 ACOX2 ACOX2 RXRB RXRB ENSUAMP00000034370 ENSUAMP00000034370 CYP4B1 CYP4B1 ILK ILK ENSUAMP00000033673 ENSUAMP00000033673 ENSUAMP00000033467 ENSUAMP00000033467 ENSUAMP00000033437 ENSUAMP00000033437 NR1I3 NR1I3 HMGCS2 HMGCS2 SORBS3 SORBS3 CPT1A CPT1A SLC27A2 SLC27A2 PCK2 PCK2 ENSUAMP00000030237 ENSUAMP00000030237 PLIN1 PLIN1 SORBS1 SORBS1 ENSUAMP00000027845 ENSUAMP00000027845 ENSUAMP00000027844 ENSUAMP00000027844 CYP27A1 CYP27A1 ENSUAMP00000027762 ENSUAMP00000027762 ENSUAMP00000027453 ENSUAMP00000027453 ENSUAMP00000027448 ENSUAMP00000027448 RXRA RXRA ENSUAMP00000026668 ENSUAMP00000026668 SLC27A4 SLC27A4 ENSUAMP00000025916 ENSUAMP00000025916 APOA5 APOA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APOC3Apolipoprotein C3. (100 aa)
APOA1Apolipoprotein A1. (266 aa)
SIK3SIK family kinase 3. (1217 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ENSUAMP00000025327Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
ENSUAMP00000025004Uncharacterized protein; Belongs to the CD36 family. (96 aa)
FABP1Fatty acid binding protein 1. (127 aa)
ANKRD24Ankyrin repeat domain 24. (1107 aa)
PLIN4Perilipin 4. (1412 aa)
PLIN5Perilipin; Belongs to the perilipin family. (457 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (436 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
OLR1Oxidized low density lipoprotein receptor 1. (192 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (476 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (703 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
MMP1Matrix metallopeptidase 1. (466 aa)
ENSUAMP00000021598ZnMc domain-containing protein. (507 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (659 aa)
MMP8Matrix metallopeptidase 8. (477 aa)
SCP2Sterol carrier protein 2. (457 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ENSUAMP00000019436SoHo domain-containing protein. (238 aa)
ENSUAMP00000019433Uncharacterized protein. (492 aa)
ENSUAMP00000019124Uncharacterized protein. (241 aa)
ENSUAMP00000019082Uncharacterized protein; Belongs to the cytochrome P450 family. (411 aa)
ENSUAMP00000018915AMP-binding domain-containing protein. (730 aa)
ENSUAMP00000018783Protein kinase domain-containing protein. (158 aa)
PLIN3Perilipin; Belongs to the perilipin family. (438 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ENSUAMP00000017426Cytochrome b5 heme-binding domain-containing protein. (478 aa)
ME1Malic enzyme. (580 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ENSUAMP00000015938Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (134 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (421 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
PLTPPhospholipid transfer protein. (496 aa)
ENSUAMP00000012555Uncharacterized protein. (284 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (126 aa)
FABP9Fatty acid binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
PMP2Peripheral myelin protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
ENSUAMP00000012166FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (379 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (659 aa)
ENSUAMP00000011703ACB domain-containing protein. (87 aa)
ENSUAMP00000011619Malic_M domain-containing protein. (256 aa)
ENSUAMP00000011425Malic domain-containing protein. (254 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
ACADLAcyl-CoA dehydrogenase long chain. (542 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
ENSUAMP00000010243Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (318 aa)
ENSUAMP00000009785Uncharacterized protein; Belongs to the CD36 family. (215 aa)
ENSUAMP00000008973FABP domain-containing protein. (128 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
PKIBcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (78 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
ANGPTL4Angiopoietin like 4. (239 aa)
ENSUAMP00000006936ACB domain-containing protein. (87 aa)
FABP12Fatty acid binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (150 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (414 aa)
ENSUAMP00000004668Uncharacterized protein. (95 aa)
ENSUAMP00000004665AMP-binding domain-containing protein. (629 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (655 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
ACBD7Acyl-CoA binding domain containing 7. (94 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
FADS3Fatty acid desaturase 3. (443 aa)
ENSUAMP00000002211FA_desaturase domain-containing protein. (243 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PLIN2Perilipin; Belongs to the perilipin family. (438 aa)
ENSUAMP00000001923FABP domain-containing protein. (128 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (660 aa)
ENSUAMP00000001197Uncharacterized protein. (228 aa)
ENSUAMP00000001167AMP-binding domain-containing protein. (493 aa)
FABP2Fatty acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
ENSUAMP00000000674Uncharacterized protein. (258 aa)
ENSUAMP00000037358Uncharacterized protein. (119 aa)
SLC27A6Solute carrier family 27 member 6. (476 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (515 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
RXRBRetinoid X receptor beta. (532 aa)
ENSUAMP00000034370ACB domain-containing protein. (124 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (493 aa)
ILKIntegrin linked kinase. (503 aa)
ENSUAMP00000033673Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (342 aa)
ENSUAMP00000033467annotation not available (164 aa)
ENSUAMP00000033437Uncharacterized protein. (181 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3. (356 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
SORBS3Sorbin and SH3 domain containing 3. (675 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
SLC27A2Solute carrier family 27 member 2. (385 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
ENSUAMP00000030237Uncharacterized protein. (68 aa)
PLIN1Perilipin; Belongs to the perilipin family. (507 aa)
SORBS1Sorbin and SH3 domain containing 1. (861 aa)
ENSUAMP00000027845Uncharacterized protein. (347 aa)
ENSUAMP00000027844Nuc_recep-AF1 domain-containing protein. (202 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (441 aa)
ENSUAMP00000027762Uncharacterized protein. (188 aa)
ENSUAMP00000027453FGGY_N domain-containing protein. (112 aa)
ENSUAMP00000027448FGGY_C domain-containing protein. (315 aa)
RXRARetinoid X receptor alpha. (469 aa)
ENSUAMP00000026668Uncharacterized protein. (112 aa)
SLC27A4Solute carrier family 27 member 4. (645 aa)
ENSUAMP00000025916FGGY_N domain-containing protein. (128 aa)
APOA5Apolipoprotein A5. (367 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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