STRINGSTRING
ENSUAMP00000006452 ENSUAMP00000006452 DMC1 DMC1 POLD2 POLD2 ENSUAMP00000004964 ENSUAMP00000004964 ENSUAMP00000004842 ENSUAMP00000004842 SASS6 SASS6 RAD52 RAD52 RECQL5 RECQL5 ENSUAMP00000003401 ENSUAMP00000003401 ENSUAMP00000003100 ENSUAMP00000003100 BRCC3 BRCC3 ENSUAMP00000002249 ENSUAMP00000002249 ABRAXAS2 ABRAXAS2 ENSUAMP00000001182 ENSUAMP00000001182 ENSUAMP00000000915 ENSUAMP00000000915 ENSUAMP00000000658 ENSUAMP00000000658 SUGP1 SUGP1 TM6SF2 TM6SF2 ENSUAMP00000008823 ENSUAMP00000008823 N4BP2 N4BP2 BARD1 BARD1 ENSUAMP00000009459 ENSUAMP00000009459 PITHD1 PITHD1 ENSUAMP00000011011 ENSUAMP00000011011 SAP130 SAP130 ENSUAMP00000011356 ENSUAMP00000011356 RTEL1 RTEL1 RAD51C RAD51C ENSUAMP00000013130 ENSUAMP00000013130 TOP3A TOP3A TOP3B TOP3B ENSUAMP00000013972 ENSUAMP00000013972 PRKRIP1 PRKRIP1 EME1 EME1 BABAM1 BABAM1 RAD54L RAD54L LURAP1 LURAP1 XRCC3 XRCC3 SLC4A1AP SLC4A1AP HELQ HELQ ABRAXAS1 ABRAXAS1 ENSUAMP00000016504 ENSUAMP00000016504 ENSUAMP00000016897 ENSUAMP00000016897 GTF3C6 GTF3C6 ENSUAMP00000017193 ENSUAMP00000017193 ENSUAMP00000017487 ENSUAMP00000017487 ENSUAMP00000017784 ENSUAMP00000017784 ENSUAMP00000017787 ENSUAMP00000017787 ENSUAMP00000017790 ENSUAMP00000017790 BRCA2 BRCA2 SSBP1 SSBP1 POLD1 POLD1 ENSUAMP00000019602 ENSUAMP00000019602 RPA1 RPA1 PIF1 PIF1 PALB2 PALB2 MRE11 MRE11 ENSUAMP00000022953 ENSUAMP00000022953 NBN NBN C12orf66 C12orf66 ENSUAMP00000024291 ENSUAMP00000024291 YJU2 YJU2 MPHOSPH9 MPHOSPH9 ENSUAMP00000025234 ENSUAMP00000025234 RAD51B RAD51B ENSUAMP00000025707 ENSUAMP00000025707 MUS81 MUS81 TOPBP1 TOPBP1 UNC93A UNC93A ENSUAMP00000028972 ENSUAMP00000028972 ENSUAMP00000029109 ENSUAMP00000029109 ENSUAMP00000029591 ENSUAMP00000029591 ENSUAMP00000029850 ENSUAMP00000029850 BRIP1 BRIP1 PTGDR2 PTGDR2 FICD FICD UNC93B1 UNC93B1 ENSUAMP00000031944 ENSUAMP00000031944 SUGP2 SUGP2 SYCP3 SYCP3 CNP CNP ENSUAMP00000032773 ENSUAMP00000032773 ENSUAMP00000032845 ENSUAMP00000032845 ENSUAMP00000034036 ENSUAMP00000034036 HELB HELB ENSUAMP00000034252 ENSUAMP00000034252 ENSUAMP00000034719 ENSUAMP00000034719 XRCC2 XRCC2 ENSUAMP00000035632 ENSUAMP00000035632 STN1 STN1 ENSUAMP00000036779 ENSUAMP00000036779 ATRX ATRX RBBP8 RBBP8 ENSUAMP00000006705 ENSUAMP00000006705
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000006452Zinc-hook domain-containing protein. (855 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (328 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
ENSUAMP00000004842Uncharacterized protein. (94 aa)
SASS6SAS-6 centriolar assembly protein. (617 aa)
RAD52RAD52 homolog, DNA repair protein. (415 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
ENSUAMP00000003401Reverse transcriptase domain-containing protein. (145 aa)
ENSUAMP00000003100Uncharacterized protein. (106 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (288 aa)
ENSUAMP00000002249Reverse transcriptase domain-containing protein. (92 aa)
ABRAXAS2Abraxas 2, BRISC complex subunit. (393 aa)
ENSUAMP00000001182DUF1725 domain-containing protein. (80 aa)
ENSUAMP00000000915Reverse transcriptase domain-containing protein. (65 aa)
ENSUAMP00000000658Uncharacterized protein. (70 aa)
SUGP1SURP and G-patch domain containing 1. (622 aa)
TM6SF2Transmembrane 6 superfamily member 2. (449 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
N4BP2NEDD4 binding protein 2. (1833 aa)
BARD1BRCA1 associated RING domain 1. (780 aa)
ENSUAMP00000009459Uncharacterized protein. (148 aa)
PITHD1PITH domain containing 1. (118 aa)
ENSUAMP00000011011Uncharacterized protein. (465 aa)
SAP130Sin3A associated protein 130. (973 aa)
ENSUAMP00000011356Uncharacterized protein. (195 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1307 aa)
RAD51CRAD51 paralog C. (362 aa)
ENSUAMP00000013130ANK_REP_REGION domain-containing protein. (393 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (992 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
ENSUAMP00000013972Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (163 aa)
PRKRIP1PRKR interacting protein 1. (187 aa)
EME1Essential meiotic structure-specific endonuclease 1. (576 aa)
BABAM1BRISC and BRCA1 A complex member 1. (336 aa)
RAD54LRAD54 like. (745 aa)
LURAP1Leucine rich adaptor protein 1. (240 aa)
XRCC3X-ray repair cross complementing 3. (448 aa)
SLC4A1APSolute carrier family 4 member 1 adaptor protein. (682 aa)
HELQHelicase, POLQ like. (1096 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (364 aa)
ENSUAMP00000016504BRCT domain-containing protein. (101 aa)
ENSUAMP00000016897Uncharacterized protein. (67 aa)
GTF3C6General transcription factor IIIC subunit 6. (239 aa)
ENSUAMP00000017193Uncharacterized protein. (91 aa)
ENSUAMP00000017487Uncharacterized protein. (108 aa)
ENSUAMP00000017784Uncharacterized protein. (638 aa)
ENSUAMP00000017787Uncharacterized protein. (167 aa)
ENSUAMP00000017790Uncharacterized protein. (126 aa)
BRCA2BRCA2 DNA repair associated. (3458 aa)
SSBP1Single stranded DNA binding protein 1. (143 aa)
POLD1DNA polymerase. (1109 aa)
ENSUAMP00000019602AAA_23 domain-containing protein. (520 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (646 aa)
PALB2Partner and localizer of BRCA2. (1177 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ENSUAMP00000022953Uncharacterized protein. (576 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
C12orf66Chromosome 12 open reading frame 66. (320 aa)
ENSUAMP00000024291Uncharacterized protein. (76 aa)
YJU2YJU2 splicing factor homolog. (298 aa)
MPHOSPH9M-phase phosphoprotein 9. (1033 aa)
ENSUAMP00000025234Uncharacterized protein. (88 aa)
RAD51BRAD51 paralog B. (271 aa)
ENSUAMP00000025707Uncharacterized protein. (652 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1514 aa)
UNC93AUnc-93 homolog A. (456 aa)
ENSUAMP00000028972Uncharacterized protein. (262 aa)
ENSUAMP00000029109RECA_2 domain-containing protein. (300 aa)
ENSUAMP00000029591Uncharacterized protein. (70 aa)
ENSUAMP00000029850Uncharacterized protein. (271 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (993 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (386 aa)
FICDFIC domain containing. (458 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (610 aa)
ENSUAMP00000031944Uncharacterized protein. (79 aa)
SUGP2SURP and G-patch domain containing 2. (1100 aa)
SYCP3Synaptonemal complex protein 3. (217 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (420 aa)
ENSUAMP00000032773RAP80_UIM domain-containing protein. (151 aa)
ENSUAMP00000032845Cor1 domain-containing protein. (214 aa)
ENSUAMP00000034036UvrD_C_2 domain-containing protein. (217 aa)
HELBDNA helicase B. (838 aa)
ENSUAMP00000034252Uncharacterized protein. (95 aa)
ENSUAMP00000034719DUF1725 domain-containing protein. (94 aa)
XRCC2X-ray repair cross complementing 2. (281 aa)
ENSUAMP00000035632Uncharacterized protein. (146 aa)
STN1STN1 subunit of CST complex. (285 aa)
ENSUAMP00000036779Uncharacterized protein. (167 aa)
ATRXATRX chromatin remodeler. (2087 aa)
RBBP8RB binding protein 8, endonuclease. (873 aa)
ENSUAMP00000006705Uncharacterized protein. (266 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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