(17 nodes) Non-homologous end-joining network (Ursus americanus)

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second shell of interactors

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Your Input:
	LRMDA	Leucine rich melanocyte differentiation associated. (143 aa)
	LIG4	DNA ligase. (911 aa)
	XRCC4	X-ray repair cross complementing 4. (320 aa)
	XRCC5	X-ray repair cross complementing 5. (501 aa)
	ENSUAMP00000005254	DNA_pol_lambd_f domain-containing protein. (277 aa)
	ENSUAMP00000005256	BRCT domain-containing protein. (190 aa)
	ENSUAMP00000006452	Zinc-hook domain-containing protein. (855 aa)
	NHEJ1	Non-homologous end joining factor 1. (238 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3341 aa)
	XRCC6	X-ray repair cross complementing 6. (527 aa)
	ENSUAMP00000019602	AAA_23 domain-containing protein. (520 aa)
	ENKD1	Enkurin domain containing 1. (346 aa)
	GTF3C3	General transcription factor IIIC subunit 3. (875 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (537 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNTT	FEN1	ENSUAMP00000026832	ENSUAMP00000023644	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.597
DNTT	LIG4	ENSUAMP00000026832	ENSUAMP00000004110	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA ligase.	0.606
DNTT	POLL	ENSUAMP00000026832	ENSUAMP00000031415	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.405
DNTT	PRKDC	ENSUAMP00000026832	ENSUAMP00000010765	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.494
DNTT	XRCC5	ENSUAMP00000026832	ENSUAMP00000004564	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	X-ray repair cross complementing 5.	0.514
DNTT	XRCC6	ENSUAMP00000026832	ENSUAMP00000017637	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	X-ray repair cross complementing 6.	0.563
ENKD1	FEN1	ENSUAMP00000020229	ENSUAMP00000023644	Enkurin domain containing 1.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.597
ENKD1	LIG4	ENSUAMP00000020229	ENSUAMP00000004110	Enkurin domain containing 1.	DNA ligase.	0.564
ENKD1	XRCC5	ENSUAMP00000020229	ENSUAMP00000004564	Enkurin domain containing 1.	X-ray repair cross complementing 5.	0.462
ENKD1	XRCC6	ENSUAMP00000020229	ENSUAMP00000017637	Enkurin domain containing 1.	X-ray repair cross complementing 6.	0.517
ENSUAMP00000005254	FEN1	ENSUAMP00000005254	ENSUAMP00000023644	DNA_pol_lambd_f domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.597
ENSUAMP00000005254	LIG4	ENSUAMP00000005254	ENSUAMP00000004110	DNA_pol_lambd_f domain-containing protein.	DNA ligase.	0.727
ENSUAMP00000005254	POLL	ENSUAMP00000005254	ENSUAMP00000031415	DNA_pol_lambd_f domain-containing protein.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.489
ENSUAMP00000005254	PRKDC	ENSUAMP00000005254	ENSUAMP00000010765	DNA_pol_lambd_f domain-containing protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.569
ENSUAMP00000005254	XRCC5	ENSUAMP00000005254	ENSUAMP00000004564	DNA_pol_lambd_f domain-containing protein.	X-ray repair cross complementing 5.	0.569
ENSUAMP00000005254	XRCC6	ENSUAMP00000005254	ENSUAMP00000017637	DNA_pol_lambd_f domain-containing protein.	X-ray repair cross complementing 6.	0.613
ENSUAMP00000005256	FEN1	ENSUAMP00000005256	ENSUAMP00000023644	BRCT domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.597
ENSUAMP00000005256	LIG4	ENSUAMP00000005256	ENSUAMP00000004110	BRCT domain-containing protein.	DNA ligase.	0.727
ENSUAMP00000005256	POLL	ENSUAMP00000005256	ENSUAMP00000031415	BRCT domain-containing protein.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.456
ENSUAMP00000005256	PRKDC	ENSUAMP00000005256	ENSUAMP00000010765	BRCT domain-containing protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.569