STRINGSTRING
RRAD RRAD PRKCB PRKCB ENSUAMP00000007617 ENSUAMP00000007617 CDKN1B CDKN1B PAK1 PAK1 RPS6KB2 RPS6KB2 ABL2 ABL2 PAK6 PAK6 ENSUAMP00000003693 ENSUAMP00000003693 PAK4 PAK4 CEP152 CEP152 EGF EGF TMEFF2 TMEFF2 ENSUAMP00000001020 ENSUAMP00000001020 ENSUAMP00000000785 ENSUAMP00000000785 ENSUAMP00000000176 ENSUAMP00000000176 ENSUAMP00000032382 ENSUAMP00000032382 ENSUAMP00000031719 ENSUAMP00000031719 MYC MYC MAPK3 MAPK3 STAT5B STAT5B PTK2 PTK2 HBEGF HBEGF ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 AKT2 AKT2 ENSUAMP00000037288 ENSUAMP00000037288 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000036162 ENSUAMP00000036162 ENSUAMP00000035331 ENSUAMP00000035331 NCK1 NCK1 MAP2K4 MAP2K4 ARSI ARSI ENSUAMP00000032909 ENSUAMP00000032909 SOS1 SOS1 REM1 REM1 GAB1 GAB1 EIF4EBP1 EIF4EBP1 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 SRC SRC ENSUAMP00000029031 ENSUAMP00000029031 MAPK9 MAPK9 CDKN1A CDKN1A ENSUAMP00000028179 ENSUAMP00000028179 ENSUAMP00000028178 ENSUAMP00000028178 MAP2K7 MAP2K7 ELK1 ELK1 ENSUAMP00000026993 ENSUAMP00000026993 PAK5 PAK5 ENSUAMP00000025300 ENSUAMP00000025300 BRAF BRAF PAK2 PAK2 MAPK10 MAPK10 RPS6KB1 RPS6KB1 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000021381 ENSUAMP00000021381 ENSUAMP00000021380 ENSUAMP00000021380 BTC BTC GEM GEM KRAS KRAS PRKCG PRKCG ENSUAMP00000020328 ENSUAMP00000020328 CAMK2B CAMK2B PIK3CD PIK3CD MTOR MTOR PPP1R14B PPP1R14B BAD BAD ENSUAMP00000019181 ENSUAMP00000019181 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000018330 ENSUAMP00000018330 SHC1 SHC1 CBL CBL ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000017435 ENSUAMP00000017435 NCK2 NCK2 MSANTD3 MSANTD3 TMEFF1 TMEFF1 CRK CRK ENSUAMP00000016279 ENSUAMP00000016279 EREG EREG AREG AREG ENSUAMP00000016265 ENSUAMP00000016265 ENSUAMP00000015993 ENSUAMP00000015993 SOS2 SOS2 ENSUAMP00000014949 ENSUAMP00000014949 ALKBH4 ALKBH4 STAT5A STAT5A ENSUAMP00000013867 ENSUAMP00000013867 ERAS ERAS MAPK1 MAPK1 ERBB3 ERBB3 GRB2 GRB2 GSK3B GSK3B AKT3 AKT3 ERBB2 ERBB2 CBLB CBLB PAK3 PAK3 AKT1 AKT1 PRKCA PRKCA PIK3R1 PIK3R1 REM2 REM2 PLCG1 PLCG1 ENSUAMP00000010013 ENSUAMP00000010013 ABL1 ABL1 ELK3 ELK3 MAPK8 MAPK8 ENSUAMP00000009254 ENSUAMP00000009254 PIK3CA PIK3CA JUN JUN CRKL CRKL PLCG2 PLCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (373 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ABL2Tyrosine-protein kinase. (1127 aa)
PAK6P21 (RAC1) activated kinase 6. (684 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
PAK4Non-specific serine/threonine protein kinase. (488 aa)
CEP152Centrosomal protein 152. (1716 aa)
EGFEpidermal growth factor. (979 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
ENSUAMP00000001020Uncharacterized protein. (147 aa)
ENSUAMP00000000785SH2 domain-containing protein. (91 aa)
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
STAT5BSignal transducer and activator of transcription. (784 aa)
PTK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (976 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037288Uncharacterized protein. (95 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
NCK1Cytoplasmic protein. (377 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
ARSIArylsulfatase family member I. (573 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (313 aa)
GAB1GRB2 associated binding protein 1. (721 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
SRCTyrosine-protein kinase. (557 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ELK1ETS transcription factor ELK1. (435 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000021381Protein kinase domain-containing protein. (363 aa)
ENSUAMP00000021380Uncharacterized protein. (424 aa)
BTCBetacellulin. (164 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
ENSUAMP00000020328Uncharacterized protein. (224 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000018330Uncharacterized protein. (346 aa)
SHC1SHC adaptor protein 1. (474 aa)
CBLCbl proto-oncogene. (796 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
NCK2NCK adaptor protein 2. (307 aa)
MSANTD3Myb/SANT DNA binding domain containing 3. (274 aa)
TMEFF1Transmembrane protein with EGF like and two follistatin like domains 1. (380 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
ENSUAMP00000016279Uncharacterized protein. (85 aa)
EREGEpiregulin. (175 aa)
AREGAmphiregulin. (257 aa)
ENSUAMP00000016265PID domain-containing protein. (219 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
ENSUAMP00000014949FERM domain-containing protein. (121 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (302 aa)
STAT5ASignal transducer and activator of transcription. (797 aa)
ENSUAMP00000013867Ig-like domain-containing protein. (130 aa)
ERASES cell expressed Ras. (219 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1281 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
CBLBCbl proto-oncogene B. (717 aa)
PAK3P21 (RAC1) activated kinase 3. (547 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
REM2RRAD and GEM like GTPase 2. (340 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
ELK3ETS transcription factor ELK3. (402 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000009254SH3 domain-containing protein. (89 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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