STRINGSTRING
PPP1CB PPP1CB SLC8A2 SLC8A2 AKT2 AKT2 PPIF PPIF GNAI2 GNAI2 ENSUAMP00000037274 ENSUAMP00000037274 ATP2B3 ATP2B3 PDE2A PDE2A CNGA1 CNGA1 ADRB2 ADRB2 ADRA2A ADRA2A ADRA1D ADRA1D ADCY6 ADCY6 ENSUAMP00000035681 ENSUAMP00000035681 CALM2 CALM2 CREB3 CREB3 CREB3L1 CREB3L1 ENSUAMP00000034960 ENSUAMP00000034960 ENSUAMP00000034850 ENSUAMP00000034850 ENSUAMP00000034830 ENSUAMP00000034830 ENSUAMP00000034022 ENSUAMP00000034022 MYH8 MYH8 ENSUAMP00000033448 ENSUAMP00000033448 PRKG2 PRKG2 ENSUAMP00000033199 ENSUAMP00000033199 MYH1 MYH1 ENSUAMP00000032843 ENSUAMP00000032843 NOS3 NOS3 ENSUAMP00000032619 ENSUAMP00000032619 PPP3CC PPP3CC ADCY7 ADCY7 ATP2B2 ATP2B2 ADCY4 ADCY4 CREB3L4 CREB3L4 MAPK3 MAPK3 KCNJ8 KCNJ8 ENSUAMP00000031223 ENSUAMP00000031223 ATP1B1 ATP1B1 ENSUAMP00000030787 ENSUAMP00000030787 ENSUAMP00000030764 ENSUAMP00000030764 RAF1 RAF1 MYLK2 MYLK2 MAP2K1 MAP2K1 ENSUAMP00000030280 ENSUAMP00000030280 ENSUAMP00000029679 ENSUAMP00000029679 MEF2C MEF2C IRS1 IRS1 CACNA1F CACNA1F ENSUAMP00000029031 ENSUAMP00000029031 ENSUAMP00000029005 ENSUAMP00000029005 PLCB4 PLCB4 MYLK MYLK GUCY1B1 GUCY1B1 ADCY1 ADCY1 EDNRB EDNRB ADCY5 ADCY5 MRVI1 MRVI1 INS INS CREB5 CREB5 ATP2A1 ATP2A1 SLC25A31 SLC25A31 ENSUAMP00000026182 ENSUAMP00000026182 VASP VASP MEF2B MEF2B GNA12 GNA12 GNA11 GNA11 ENSUAMP00000000802 ENSUAMP00000000802 GUCY1A1 GUCY1A1 ENSUAMP00000000947 ENSUAMP00000000947 ADRA1A ADRA1A ATP1B2 ATP1B2 ENSUAMP00000001579 ENSUAMP00000001579 ENSUAMP00000002341 ENSUAMP00000002341 IRS4 IRS4 ENSUAMP00000003355 ENSUAMP00000003355 ENSUAMP00000003358 ENSUAMP00000003358 ENSUAMP00000003698 ENSUAMP00000003698 ENSUAMP00000003880 ENSUAMP00000003880 ENSUAMP00000003964 ENSUAMP00000003964 SLC8A1 SLC8A1 ENSUAMP00000004579 ENSUAMP00000004579 PLCB2 PLCB2 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 ATF4 ATF4 ATP1B4 ATP1B4 ATP1A1 ATP1A1 CACNA1S CACNA1S ITPR3 ITPR3 ADCY9 ADCY9 ENSUAMP00000005976 ENSUAMP00000005976 PIK3CG PIK3CG ENSUAMP00000006289 ENSUAMP00000006289 ENSUAMP00000006694 ENSUAMP00000006694 KCNMA1 KCNMA1 ENSUAMP00000007288 ENSUAMP00000007288 ATP2B4 ATP2B4 NPPC NPPC ADORA1 ADORA1 ENSUAMP00000007690 ENSUAMP00000007690 VDAC1 VDAC1 GNAI3 GNAI3 PPP3CA PPP3CA NFATC4 NFATC4 ADCY2 ADCY2 CALML5 CALML5 RHOB RHOB ADCY3 ADCY3 GATA4 GATA4 ATP2B1 ATP2B1 SLC8A3 SLC8A3 ENSUAMP00000009775 ENSUAMP00000009775 ATF2 ATF2 PPP3CB PPP3CB GTF2I GTF2I GTF2IRD1 GTF2IRD1 AKT1 AKT1 PLCB1 PLCB1 ENSUAMP00000010858 ENSUAMP00000010858 ENSUAMP00000010867 ENSUAMP00000010867 MYLK3 MYLK3 NFATC1 NFATC1 AKT3 AKT3 ENSUAMP00000011731 ENSUAMP00000011731 NPR2 NPR2 OPRD1 OPRD1 ENSUAMP00000012405 ENSUAMP00000012405 ENSUAMP00000012729 ENSUAMP00000012729 ATP2A2 ATP2A2 ENSUAMP00000013458 ENSUAMP00000013458 ENSUAMP00000013482 ENSUAMP00000013482 MAPK1 MAPK1 ENSUAMP00000013707 ENSUAMP00000013707 PPP1CC PPP1CC CALML6 CALML6 ADRA2B ADRA2B IRS2 IRS2 ENSUAMP00000014629 ENSUAMP00000014629 ENSUAMP00000014648 ENSUAMP00000014648 ENSUAMP00000014650 ENSUAMP00000014650 ENSUAMP00000014661 ENSUAMP00000014661 ENSUAMP00000014933 ENSUAMP00000014933 AGTR1 AGTR1 SLC25A4 SLC25A4 ATP1A2 ATP1A2 RGS2 RGS2 MEF2D MEF2D MYL9 MYL9 ATP2A3 ATP2A3 ENSUAMP00000017736 ENSUAMP00000017736 CACNA1D CACNA1D PLN PLN ROCK1 ROCK1 SLC25A5 SLC25A5 BAD BAD PLCB3 PLCB3 PPP1R14B PPP1R14B CALML4 CALML4 ENSUAMP00000019938 ENSUAMP00000019938 SRF SRF PTK7 PTK7 PIK3R6 PIK3R6 PIK3R5 PIK3R5 KCNMB1 KCNMB1 ADRA1B ADRA1B NFATC3 NFATC3 VDAC3 VDAC3 ATF6B ATF6B GNAQ GNAQ ENSUAMP00000021442 ENSUAMP00000021442 ENSUAMP00000021447 ENSUAMP00000021447 PDE3A PDE3A ENSUAMP00000021520 ENSUAMP00000021520 CALM3 CALM3 ENSUAMP00000021954 ENSUAMP00000021954 ENSUAMP00000022172 ENSUAMP00000022172 INSR INSR ENSUAMP00000023102 ENSUAMP00000023102 ENSUAMP00000023390 ENSUAMP00000023390 MEF2A MEF2A CREB1 CREB1 ATP1B3 ATP1B3 ENSUAMP00000024427 ENSUAMP00000024427 ROCK2 ROCK2 CREB3L3 CREB3L3 NPPA NPPA NPPB NPPB ENSUAMP00000025311 ENSUAMP00000025311 BDKRB2 BDKRB2 ATP1A4 ATP1A4 ENSUAMP00000025726 ENSUAMP00000025726
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (902 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
GNAI2G protein subunit alpha i2. (436 aa)
ENSUAMP00000037274Uncharacterized protein. (439 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1254 aa)
PDE2APhosphodiesterase. (975 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (676 aa)
ADRB2Adrenoceptor beta 2. (418 aa)
ADRA2AAdrenoceptor alpha 2A. (421 aa)
ADRA1DAdrenoceptor alpha 1D. (510 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (163 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
ENSUAMP00000034850Uncharacterized protein. (294 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
ENSUAMP00000034022Uncharacterized protein. (97 aa)
MYH8Myosin heavy chain 8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
ENSUAMP00000033448Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1911 aa)
PRKG2cGMP-dependent protein kinase. (711 aa)
ENSUAMP00000033199RHD domain-containing protein. (458 aa)
MYH1Myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
ENSUAMP00000032619Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PPP3CCSerine/threonine-protein phosphatase. (449 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
ENSUAMP00000031223Uncharacterized protein. (430 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
ENSUAMP00000030764Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1123 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
MYLK2Myosin light chain kinase 2. (615 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
ENSUAMP00000029679Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSUAMP00000029005GAF domain-containing protein. (263 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
MYLKMyosin light chain kinase. (1485 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (540 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (445 aa)
ADCY5Adenylate cyclase 5. (940 aa)
MRVI1Murine retrovirus integration site 1 homolog. (913 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1060 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
ENSUAMP00000026182Abhydrolase_3 domain-containing protein. (237 aa)
VASPVasodilator stimulated phosphoprotein. (359 aa)
MEF2BMyocyte enhancer factor 2B. (373 aa)
GNA12G protein subunit alpha 12. (350 aa)
GNA11G protein subunit alpha 11. (353 aa)
ENSUAMP00000000802Uncharacterized protein. (67 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (681 aa)
ENSUAMP00000000947Phosphodiesterase. (550 aa)
ADRA1AAdrenoceptor alpha 1A. (319 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSUAMP00000001579Cation_ATPase_N domain-containing protein. (75 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
IRS4Insulin receptor substrate 4. (1256 aa)
ENSUAMP00000003355Uncharacterized protein. (76 aa)
ENSUAMP00000003358SER_THR_PHOSPHATASE domain-containing protein. (106 aa)
ENSUAMP00000003698Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (164 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
ENSUAMP00000003964FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (59 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (619 aa)
ENSUAMP00000004579Abhydrolase_3 domain-containing protein. (224 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
ATF4Activating transcription factor 4. (351 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
ENSUAMP00000006289Uncharacterized protein. (158 aa)
ENSUAMP00000006694SER_THR_PHOSPHATASE domain-containing protein. (148 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
ENSUAMP00000007288Ca_chan_IQ domain-containing protein. (832 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1260 aa)
NPPCNatriuretic peptide C. (126 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
ENSUAMP00000007690Uncharacterized protein. (259 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
GNAI3G protein subunit alpha i3. (295 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
NFATC4Nuclear factor of activated T cells 4. (911 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CALML5Calmodulin like 5. (156 aa)
RHOBRas homolog family member B. (172 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
GATA4GATA binding protein 4. (443 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
GTF2IGeneral transcription factor IIi. (999 aa)
GTF2IRD1GTF2I repeat domain containing 1. (1017 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
ENSUAMP00000010858Myosin_tail_1 domain-containing protein. (890 aa)
ENSUAMP00000010867Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (207 aa)
MYLK3Myosin light chain kinase 3. (791 aa)
NFATC1Nuclear factor of activated T cells 1. (931 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
NPR2Guanylate cyclase. (1048 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
ENSUAMP00000012729RHD domain-containing protein. (481 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ENSUAMP00000013458KcnmB2_inactiv domain-containing protein. (235 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ENSUAMP00000013707Uncharacterized protein. (382 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
CALML6Calmodulin like 6. (180 aa)
ADRA2BAdrenoceptor alpha 2B. (445 aa)
IRS2Insulin receptor substrate 2. (1089 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
ENSUAMP00000014648Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (318 aa)
ENSUAMP00000014650G_PROTEIN_RECEP_F1_2 domain-containing protein. (199 aa)
ENSUAMP00000014661Uncharacterized protein. (241 aa)
ENSUAMP00000014933Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (286 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (361 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1127 aa)
RGS2Regulator of G protein signaling 2. (204 aa)
MEF2DMyocyte enhancer factor 2D. (515 aa)
MYL9Myosin light chain 9. (172 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
ENSUAMP00000017736Cation_ATPase_N domain-containing protein. (54 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
CALML4Calmodulin like 4. (153 aa)
ENSUAMP00000019938Uncharacterized protein. (193 aa)
SRFSerum response factor. (507 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (869 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
ADRA1BAdrenoceptor alpha 1B. (311 aa)
NFATC3Nuclear factor of activated T cells 3. (1079 aa)
VDAC3Voltage dependent anion channel 3. (279 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GNAQG protein subunit alpha q. (352 aa)
ENSUAMP00000021442Uncharacterized protein. (307 aa)
ENSUAMP00000021447Cyclic nucleotide-binding domain-containing protein. (846 aa)
PDE3APhosphodiesterase. (777 aa)
ENSUAMP00000021520Uncharacterized protein. (210 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
INSRTyrosine-protein kinase receptor. (1072 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
ENSUAMP00000023390Uncharacterized protein. (286 aa)
MEF2AMyocyte enhancer factor 2A. (466 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
ENSUAMP00000024427Recep_L_domain domain-containing protein. (297 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
NPPANatriuretic peptide A. (182 aa)
NPPBNatriuretic peptide B. (132 aa)
ENSUAMP00000025311Uncharacterized protein. (295 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1011 aa)
ENSUAMP00000025726annotation not available (113 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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