STRINGSTRING
ENSUAMP00000000176 ENSUAMP00000000176 SLC2A1 SLC2A1 ENSUAMP00000000421 ENSUAMP00000000421 LTF LTF ENSUAMP00000001042 ENSUAMP00000001042 ENSUAMP00000001068 ENSUAMP00000001068 ENSUAMP00000001439 ENSUAMP00000001439 EGF EGF ENSUAMP00000001883 ENSUAMP00000001883 ENSUAMP00000002017 ENSUAMP00000002017 ENO3 ENO3 ENSUAMP00000002320 ENSUAMP00000002320 ANGPT1 ANGPT1 ENSUAMP00000002989 ENSUAMP00000002989 ENSUAMP00000003524 ENSUAMP00000003524 ENSUAMP00000003886 ENSUAMP00000003886 ENSUAMP00000003971 ENSUAMP00000003971 MKNK1 MKNK1 ENSUAMP00000005122 ENSUAMP00000005122 ENSUAMP00000005190 ENSUAMP00000005190 ENSUAMP00000005719 ENSUAMP00000005719 ENSUAMP00000005964 ENSUAMP00000005964 RPS6KB2 RPS6KB2 ENSUAMP00000006876 ENSUAMP00000006876 CDKN1B CDKN1B ENSUAMP00000007617 ENSUAMP00000007617 PRKCB PRKCB PLCG2 PLCG2 NOS2 NOS2 STAT3 STAT3 PIK3CA PIK3CA ENSUAMP00000009508 ENSUAMP00000009508 PLCG1 PLCG1 ENSUAMP00000010325 ENSUAMP00000010325 SERPINE1 SERPINE1 PIK3R1 PIK3R1 PRKCA PRKCA AKT1 AKT1 ERBB2 ERBB2 AKT3 AKT3 BCL2 BCL2 ARNT ARNT PFKM PFKM MAPK1 MAPK1 ENSUAMP00000014171 ENSUAMP00000014171 IGF1R IGF1R EIF4E EIF4E ENSUAMP00000016790 ENSUAMP00000016790 RPS6 RPS6 ENSUAMP00000017404 ENSUAMP00000017404 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017482 ENSUAMP00000017482 TEK TEK ENSUAMP00000017692 ENSUAMP00000017692 ALDOC ALDOC IL6R IL6R IFNGR2 IFNGR2 ENSUAMP00000019174 ENSUAMP00000019174 ENSUAMP00000019181 ENSUAMP00000019181 MTOR MTOR PIK3CD PIK3CD HMOX1 HMOX1 HK1 HK1 HKDC1 HKDC1 CAMK2B CAMK2B VEGFA VEGFA PRKCG PRKCG IGF1 IGF1 NFKB1 NFKB1 ENSUAMP00000021701 ENSUAMP00000021701 ENSUAMP00000022131 ENSUAMP00000022131 IFNGR1 IFNGR1 RPS6KB1 RPS6KB1 PFKFB3 PFKFB3 PFKP PFKP INSR INSR ANGPT2 ANGPT2 ENSUAMP00000023057 ENSUAMP00000023057 ENSUAMP00000023108 ENSUAMP00000023108 TF TF LDHAL6B LDHAL6B ENSUAMP00000024427 ENSUAMP00000024427 ENSUAMP00000024472 ENSUAMP00000024472 ENSUAMP00000024473 ENSUAMP00000024473 LDHA LDHA NPPA NPPA TBCA TBCA ENSUAMP00000025300 ENSUAMP00000025300 ELOC ELOC ENO4 ENO4 ENSUAMP00000026055 ENSUAMP00000026055 EIF4E2 EIF4E2 RELA RELA INS INS ALDOB ALDOB EGLN3 EGLN3 PGK1 PGK1 CDKN1A CDKN1A HK3 HK3 ANGPT4 ANGPT4 EIF4E1B EIF4E1B ENSUAMP00000029031 ENSUAMP00000029031 CUL2 CUL2 GAPDH GAPDH ENSUAMP00000029255 ENSUAMP00000029255 ENSUAMP00000029256 ENSUAMP00000029256 ENSUAMP00000030280 ENSUAMP00000030280 FLT1 FLT1 MAP2K1 MAP2K1 ENSUAMP00000030313 ENSUAMP00000030313 EDN1 EDN1 EIF4EBP1 EIF4EBP1 PGK2 PGK2 CREBBP CREBBP RBX1 RBX1 IL6 IL6 ENSUAMP00000031432 ENSUAMP00000031432 ENSUAMP00000031500 ENSUAMP00000031500 ENSUAMP00000031501 ENSUAMP00000031501 MAPK3 MAPK3 PDK1 PDK1 HK2 HK2 PDHA1 PDHA1 EP300 EP300 XK XK CYBB CYBB PFKL PFKL ENSUAMP00000032382 ENSUAMP00000032382 NOS3 NOS3 ENSUAMP00000032909 ENSUAMP00000032909 TLR4 TLR4 ARSI ARSI ENSUAMP00000034334 ENSUAMP00000034334 HIF1A HIF1A ENSUAMP00000035192 ENSUAMP00000035192 ENSUAMP00000035193 ENSUAMP00000035193 MKNK2 MKNK2 ENSUAMP00000035331 ENSUAMP00000035331 ENO2 ENO2 PDHB PDHB ENSUAMP00000035932 ENSUAMP00000035932 ENSUAMP00000036162 ENSUAMP00000036162 EPO EPO ENSUAMP00000037224 ENSUAMP00000037224 TFRC TFRC PDHA2 PDHA2 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000000176Protein kinase domain-containing protein. (82 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSUAMP00000000421NTR domain-containing protein. (132 aa)
LTFLactotransferrin; Belongs to the transferrin family. (706 aa)
ENSUAMP00000001042Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
ENSUAMP00000001068Ig-like domain-containing protein. (174 aa)
ENSUAMP00000001439Ldh_1_C domain-containing protein. (58 aa)
EGFEpidermal growth factor. (979 aa)
ENSUAMP00000001883Uncharacterized protein. (2586 aa)
ENSUAMP00000002017Gp_dh_N domain-containing protein. (243 aa)
ENO3Enolase 3. (445 aa)
ENSUAMP00000002320Gp_dh_C domain-containing protein. (118 aa)
ANGPT1Angiopoietin 1. (452 aa)
ENSUAMP00000002989Transferrin-like domain-containing protein. (113 aa)
ENSUAMP00000003524PFK domain-containing protein. (53 aa)
ENSUAMP00000003886Uncharacterized protein. (85 aa)
ENSUAMP00000003971Ldh_1_C domain-containing protein. (101 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (415 aa)
ENSUAMP00000005122Gp_dh_C domain-containing protein. (84 aa)
ENSUAMP00000005190Ldh_1_N domain-containing protein. (221 aa)
ENSUAMP00000005719Ldh_1_N domain-containing protein. (127 aa)
ENSUAMP00000005964Uncharacterized protein. (197 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ENSUAMP00000006876Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (187 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
ENSUAMP00000007617Protein kinase domain-containing protein. (271 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSUAMP00000009508Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (111 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
ENSUAMP00000010325Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (193 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (481 aa)
PFKMUncharacterized protein. (862 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ENSUAMP00000014171PFK domain-containing protein. (309 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (180 aa)
ENSUAMP0000001679040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (203 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSUAMP00000017404Fe2OG dioxygenase domain-containing protein. (125 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017482Uncharacterized protein. (228 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
IL6RInterleukin 6 receptor. (496 aa)
IFNGR2Interferon gamma receptor 2. (343 aa)
ENSUAMP00000019174CaMKII_AD domain-containing protein. (267 aa)
ENSUAMP00000019181Protein kinase domain-containing protein. (206 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
HMOX1Heme oxygenase 1. (288 aa)
HK1Hexokinase 1. (917 aa)
HKDC1Phosphotransferase. (630 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (589 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
IGF1Insulin like growth factor 1. (171 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ENSUAMP00000021701Fe2OG dioxygenase domain-containing protein. (233 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
IFNGR1Interferon gamma receptor 1. (505 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (544 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (803 aa)
INSRTyrosine-protein kinase receptor. (1072 aa)
ANGPT2Angiopoietin 2. (494 aa)
ENSUAMP00000023057Ubiquitin-like domain-containing protein. (126 aa)
ENSUAMP00000023108Uncharacterized protein; Belongs to the transferrin family. (600 aa)
TFTransferrin; Belongs to the transferrin family. (709 aa)
LDHAL6BL-lactate dehydrogenase. (236 aa)
ENSUAMP00000024427Recep_L_domain domain-containing protein. (297 aa)
ENSUAMP00000024472Ldh_1_C domain-containing protein. (55 aa)
ENSUAMP00000024473L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (179 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
NPPANatriuretic peptide A. (182 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (107 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
ENO4Enolase 4. (625 aa)
ENSUAMP00000026055Ldh_1_C domain-containing protein. (101 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (328 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
PGK1Phosphoglycerate kinase. (417 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
HK3Hexokinase 3. (925 aa)
ANGPT4Angiopoietin 4. (446 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (225 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (347 aa)
ENSUAMP00000029255Uncharacterized protein. (203 aa)
ENSUAMP00000029256TNFR-Cys domain-containing protein. (148 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1265 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
ENSUAMP00000030313Uncharacterized protein. (195 aa)
EDN1Endothelin 1. (202 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PGK2Phosphoglycerate kinase. (297 aa)
CREBBPCREB binding protein. (2333 aa)
RBX1Ring-box 1. (108 aa)
IL6Interleukin 6. (212 aa)
ENSUAMP00000031432Uncharacterized protein. (304 aa)
ENSUAMP00000031500Uncharacterized protein. (89 aa)
ENSUAMP00000031501Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
HK2Hexokinase 2. (898 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
EP300E1A binding protein p300. (2399 aa)
XKXK-related protein. (433 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
PFKLPhosphofructokinase, liver type. (577 aa)
ENSUAMP00000032382CaMKII_AD domain-containing protein. (189 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
ARSIArylsulfatase family member I. (573 aa)
ENSUAMP00000034334Uncharacterized protein. (94 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
ENSUAMP00000035192Uncharacterized protein. (82 aa)
ENSUAMP00000035193Uncharacterized protein. (279 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (463 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
ENO2Enolase 2. (434 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ENSUAMP00000035932Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (172 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
ENSUAMP00000037224Fe2OG dioxygenase domain-containing protein. (126 aa)
TFRCTransferrin receptor. (779 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (34%) [HD]