STRINGSTRING
PLCB2 PLCB2 S1PR1 S1PR1 ENSUAMP00000005976 ENSUAMP00000005976 PLD2 PLD2 ENSUAMP00000006289 ENSUAMP00000006289 ABCC1 ABCC1 SGPP1 SGPP1 MAP3K5 MAP3K5 ADORA1 ADORA1 PRKCB PRKCB GNAI3 GNAI3 ENSUAMP00000008403 ENSUAMP00000008403 RHOB RHOB RAC2 RAC2 SMPD1 SMPD1 MAPK3 MAPK3 ENSUAMP00000031719 ENSUAMP00000031719 DEGS1 DEGS1 RAC3 RAC3 SGPP2 SGPP2 MAPK14 MAPK14 MAPK13 MAPK13 ENSUAMP00000032533 ENSUAMP00000032533 ENSUAMP00000032535 ENSUAMP00000032535 NOS3 NOS3 ENSUAMP00000032923 ENSUAMP00000032923 PTK6 PTK6 PPP2R2D PPP2R2D AKT3 AKT3 ENSUAMP00000011147 ENSUAMP00000011147 ENSUAMP00000011028 ENSUAMP00000011028 NSMAF NSMAF ENSUAMP00000028179 ENSUAMP00000028179 PLCB4 PLCB4 MAPK9 MAPK9 CERS4 CERS4 ENSUAMP00000029031 ENSUAMP00000029031 SPTLC2 SPTLC2 TNFRSF1A TNFRSF1A SPHK1 SPHK1 SPTLC1 SPTLC1 ENSUAMP00000030280 ENSUAMP00000030280 MAP2K1 MAP2K1 PPP2R3C PPP2R3C RAC1 RAC1 ENSUAMP00000030716 ENSUAMP00000030716 RAF1 RAF1 ENSUAMP00000030787 ENSUAMP00000030787 AKT2 AKT2 GNAI2 GNAI2 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000036253 ENSUAMP00000036253 SGMS2 SGMS2 ENSUAMP00000035681 ENSUAMP00000035681 ENSUAMP00000035331 ENSUAMP00000035331 CERS2 CERS2 FCER1A FCER1A ACER1 ACER1 ENSUAMP00000033965 ENSUAMP00000033965 ADAMTS19 ADAMTS19 FCER1G FCER1G SRMS SRMS DEGS2 DEGS2 OPRD1 OPRD1 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000012405 ENSUAMP00000012405 PPP2R1A PPP2R1A BAX BAX SPHK2 SPHK2 BID BID MAPK1 MAPK1 ERAS ERAS ASAH1 ASAH1 ENSUAMP00000014629 ENSUAMP00000014629 ENSUAMP00000014648 ENSUAMP00000014648 ENSUAMP00000014650 ENSUAMP00000014650 ENSUAMP00000014661 ENSUAMP00000014661 ENSUAMP00000014981 ENSUAMP00000014981 PPP2R5B PPP2R5B TNF TNF ENSUAMP00000015993 ENSUAMP00000015993 BCL2 BCL2 PDPK1 PDPK1 MAPK12 MAPK12 MAPK11 MAPK11 ENSUAMP00000017375 ENSUAMP00000017375 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 ROCK1 ROCK1 PPP2R3A PPP2R3A PLCB3 PLCB3 PIK3CD PIK3CD TRADD TRADD ENSUAMP00000019938 ENSUAMP00000019938 PRKCG PRKCG PPP2R5A PPP2R5A KRAS KRAS GNAQ GNAQ CERS3 CERS3 NFKB1 NFKB1 PPP2R2B PPP2R2B ENSUAMP00000022131 ENSUAMP00000022131 PPP2R5D PPP2R5D ENSUAMP00000022172 ENSUAMP00000022172 ENSUAMP00000022227 ENSUAMP00000022227 PPP2R5E PPP2R5E MAPK10 MAPK10 SMPD2 SMPD2 ENSUAMP00000023048 ENSUAMP00000023048 PPP2CA PPP2CA S1PR5 S1PR5 ENSUAMP00000023976 ENSUAMP00000023976 PPP2R5C PPP2R5C ROCK2 ROCK2 ENSUAMP00000025300 ENSUAMP00000025300 BDKRB2 BDKRB2 ENSUAMP00000025837 ENSUAMP00000025837 ENSUAMP00000026182 ENSUAMP00000026182 S1PR2 S1PR2 PPP2R2A PPP2R2A RELA RELA ENSUAMP00000026993 ENSUAMP00000026993 PLCB1 PLCB1 AKT1 AKT1 PRKCA PRKCA PIK3R1 PIK3R1 ENSUAMP00000009775 ENSUAMP00000009775 ENSUAMP00000009491 ENSUAMP00000009491 MAPK8 MAPK8 PIK3CA PIK3CA ENSUAMP00000027063 ENSUAMP00000027063 IFITM10 IFITM10 FYN FYN PPP2CB PPP2CB CERS5 CERS5 ACER2 ACER2 GNA12 GNA12 S1PR3 S1PR3 TP53 TP53 PPP2R2C PPP2R2C SGPL1 SGPL1 GAB2 GAB2 TRAF2 TRAF2 ENSUAMP00000003693 ENSUAMP00000003693 SPTLC3 SPTLC3 ENSUAMP00000003880 ENSUAMP00000003880 ENSUAMP00000004579 ENSUAMP00000004579
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
PLD2Phospholipase. (1025 aa)
ENSUAMP00000006289Uncharacterized protein. (158 aa)
ABCC1ATP binding cassette subfamily C member 1. (1415 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (263 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1212 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
GNAI3G protein subunit alpha i3. (295 aa)
ENSUAMP00000008403TLC domain-containing protein. (239 aa)
RHOBRas homolog family member B. (172 aa)
RAC2Rac family small GTPase 2. (192 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
RAC3Rac family small GTPase 3. (202 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (348 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ENSUAMP00000032533Uncharacterized protein. (127 aa)
ENSUAMP00000032535Uncharacterized protein. (145 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
PTK6Tyrosine-protein kinase. (482 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011147Ion_trans domain-containing protein. (118 aa)
ENSUAMP00000011028Uncharacterized protein. (50 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (791 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
CERS4Ceramide synthase 4. (461 aa)
ENSUAMP00000029031Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
SPHK1Sphingosine kinase 1. (387 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (517 aa)
ENSUAMP00000030280Protein kinase domain-containing protein. (206 aa)
MAP2K1Protein kinase domain-containing protein. (216 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (450 aa)
RAC1Rac family small GTPase 1. (229 aa)
ENSUAMP00000030716Uncharacterized protein. (98 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNAI2G protein subunit alpha i2. (436 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000036253Protein kinase domain-containing protein. (66 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CERS2Ceramide synthase 2. (380 aa)
FCER1AFc fragment of IgE receptor Ia. (274 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
ENSUAMP00000033965Homeobox domain-containing protein. (210 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19. (792 aa)
FCER1GFc fragment of IgE receptor Ig. (80 aa)
SRMSTyrosine-protein kinase. (492 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
SPHK2Sphingosine kinase 2. (662 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (196 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ERASES cell expressed Ras. (219 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (330 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
ENSUAMP00000014648Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (318 aa)
ENSUAMP00000014650G_PROTEIN_RECEP_F1_2 domain-containing protein. (199 aa)
ENSUAMP00000014661Uncharacterized protein. (241 aa)
ENSUAMP00000014981EF-hand domain-containing protein. (176 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017375Uncharacterized protein. (208 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1153 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
ENSUAMP00000019938Uncharacterized protein. (193 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
GNAQG protein subunit alpha q. (352 aa)
CERS3Ceramide synthase 3. (402 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (601 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
ENSUAMP00000022227Uncharacterized protein. (64 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (504 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
ENSUAMP00000023048PB1 domain-containing protein. (123 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
S1PR5Sphingosine-1-phosphate receptor 5. (398 aa)
ENSUAMP00000023976Uncharacterized protein. (158 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (503 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ENSUAMP00000025837Ceramidse_alk_C domain-containing protein. (150 aa)
ENSUAMP00000026182Abhydrolase_3 domain-containing protein. (237 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (458 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
ENSUAMP00000009491C2 tensin-type domain-containing protein. (179 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSUAMP00000027063Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (410 aa)
IFITM10Interferon induced transmembrane protein 10. (225 aa)
FYNTyrosine-protein kinase. (537 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CERS5Ceramide synthase 5. (389 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
GNA12G protein subunit alpha 12. (350 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (425 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
GAB2GRB2 associated binding protein 2. (665 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (536 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
ENSUAMP00000004579Abhydrolase_3 domain-containing protein. (224 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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