STRINGSTRING
ENSUAMP00000005048 ENSUAMP00000005048 ANAPC5 ANAPC5 ENSUAMP00000018470 ENSUAMP00000018470 CDC16 CDC16 CDC6 CDC6 MAD2L1 MAD2L1 MCM5 MCM5 E2F4 E2F4 ANAPC1 ANAPC1 RBL1 RBL1 GADD45G GADD45G TGFB2 TGFB2 ENSUAMP00000021561 ENSUAMP00000021561 MCM6 MCM6 ENSUAMP00000021642 ENSUAMP00000021642 ENSUAMP00000021647 ENSUAMP00000021647 FZR1 FZR1 YWHAB YWHAB MCM4 MCM4 ENSUAMP00000023307 ENSUAMP00000023307 CDC26 CDC26 MDM2 MDM2 CDKN2D CDKN2D CDK7 CDK7 CDK1 CDK1 YWHAH YWHAH TFDP2 TFDP2 E2F5 E2F5 MCM3 MCM3 FBXW12 FBXW12 MAD2L2 MAD2L2 MYNN MYNN ORC5 ORC5 ENSUAMP00000025041 ENSUAMP00000025041 CDKN2C CDKN2C SNPH SNPH SKP2 SKP2 SMAD3 SMAD3 SMAD2 SMAD2 ENSUAMP00000027429 ENSUAMP00000027429 ENSUAMP00000027431 ENSUAMP00000027431 ENSUAMP00000027679 ENSUAMP00000027679 ANAPC2 ANAPC2 MCM2 MCM2 CDKN1A CDKN1A CUL1 CUL1 ENSUAMP00000029459 ENSUAMP00000029459 ENSUAMP00000029737 ENSUAMP00000029737 CDC25A CDC25A CREBBP CREBBP SMC1A SMC1A ANAPC4 ANAPC4 RBX1 RBX1 ENSUAMP00000031131 ENSUAMP00000031131 MYC MYC EP300 EP300 YWHAZ YWHAZ ZNF652 ZNF652 CCND1 CCND1 SFN SFN E2F1 E2F1 E2F3 E2F3 ENSUAMP00000034870 ENSUAMP00000034870 STAG2 STAG2 CDC25B CDC25B AP5S1 AP5S1 SMC3 SMC3 ANAPC13 ANAPC13 GADD45A GADD45A CCNH CCNH CCND3 CCND3 ORC3 ORC3 HDAC1 HDAC1 WEE2 WEE2 TGFB3 TGFB3 GADD45B GADD45B CDK4 CDK4 ENSUAMP00000015907 ENSUAMP00000015907 PCNA PCNA ORC4 ORC4 RB1 RB1 YWHAG YWHAG CHEK2 CHEK2 FAM126B FAM126B ORC2 ORC2 CCNA2 CCNA2 ANAPC7 ANAPC7 BUB1 BUB1 TGFB1 TGFB1 GSK3B GSK3B ENSUAMP00000011976 ENSUAMP00000011976 CDK20 CDK20 ENSUAMP00000011840 ENSUAMP00000011840 ENSUAMP00000011833 ENSUAMP00000011833 ZBTB46 ZBTB46 ORC6 ORC6 MCM7 MCM7 PRKDC PRKDC CDC27 CDC27 CDC7 CDC7 ENSUAMP00000010431 ENSUAMP00000010431 ENSUAMP00000010248 ENSUAMP00000010248 ZBTB47 ZBTB47 STAG1 STAG1 ABL1 ABL1 ENSUAMP00000009635 ENSUAMP00000009635 PKMYT1 PKMYT1 BUB3 BUB3 ANAPC10 ANAPC10 ENSUAMP00000008994 ENSUAMP00000008994 TTK TTK ENSUAMP00000008823 ENSUAMP00000008823 CCNE1 CCNE1 CDK6 CDK6 WEE1 WEE1 ENSUAMP00000007986 ENSUAMP00000007986 CCNB2 CCNB2 SKP1 SKP1 RAD21L1 RAD21L1 CDKN1B CDKN1B TFDP1 TFDP1 CHEK1 CHEK1 ENSUAMP00000006884 ENSUAMP00000006884 ZBTB10 ZBTB10 TMEM82 TMEM82 SMAD4 SMAD4 ENSUAMP00000004964 ENSUAMP00000004964 CDK3 CDK3 ENSUAMP00000004606 ENSUAMP00000004606 E2F2 E2F2 SNAPIN SNAPIN ESPL1 ESPL1 ENSUAMP00000003531 ENSUAMP00000003531 ENSUAMP00000003375 ENSUAMP00000003375 SMC1B SMC1B ENSUAMP00000002920 ENSUAMP00000002920 CCNA1 CCNA1 ENSUAMP00000002462 ENSUAMP00000002462 ENSUAMP00000002455 ENSUAMP00000002455 CCNB1 CCNB1 DBF4 DBF4 ENSUAMP00000001840 ENSUAMP00000001840 HDAC2 HDAC2 ENSUAMP00000001524 ENSUAMP00000001524 TP53 TP53 CDC20 CDC20 ENSUAMP00000000864 ENSUAMP00000000864 CDKN2B CDKN2B ENSUAMP00000000622 ENSUAMP00000000622 ORC1 ORC1 ENSUAMP00000000381 ENSUAMP00000000381
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000005048Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (241 aa)
ANAPC5Anaphase promoting complex subunit 5. (727 aa)
ENSUAMP00000018470Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
CDC16Cell division cycle 16. (624 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
E2F4E2F transcription factor 4. (406 aa)
ANAPC1APC1_C domain-containing protein. (1191 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
ENSUAMP00000021561RING-type domain-containing protein. (84 aa)
MCM6Minichromosome maintenance complex component 6; Belongs to the MCM family. (451 aa)
ENSUAMP00000021642Rad21_Rec8 domain-containing protein. (69 aa)
ENSUAMP00000021647Rad21_Rec8_N domain-containing protein. (566 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ENSUAMP00000023307Uncharacterized protein. (243 aa)
CDC26Cell division cycle 26. (85 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
CDK7Cyclin dependent kinase 7. (266 aa)
CDK1Cyclin dependent kinase 1. (305 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
TFDP2Transcription factor. (360 aa)
E2F5E2F transcription factor 5. (350 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
FBXW12F-box and WD repeat domain containing 12. (468 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
MYNNMyoneurin. (610 aa)
ORC5Origin recognition complex subunit 5. (424 aa)
ENSUAMP00000025041Protein kinase domain-containing protein. (80 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SNPHSyntaphilin. (537 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSUAMP00000027429Uncharacterized protein. (165 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
ENSUAMP00000027679Uncharacterized protein. (51 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (893 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CUL1Cullin 1; Belongs to the cullin family. (742 aa)
ENSUAMP00000029459DUF3452 domain-containing protein. (385 aa)
ENSUAMP00000029737Uncharacterized protein. (105 aa)
CDC25ACell division cycle 25A. (498 aa)
CREBBPCREB binding protein. (2333 aa)
SMC1AStructural maintenance of chromosomes protein. (1239 aa)
ANAPC4Anaphase promoting complex subunit 4. (659 aa)
RBX1Ring-box 1. (108 aa)
ENSUAMP00000031131Protein kinase domain-containing protein. (264 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
EP300E1A binding protein p300. (2399 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
ZNF652Zinc finger protein 652. (552 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
E2F1E2F transcription factor 1. (400 aa)
E2F3E2F transcription factor 3. (469 aa)
ENSUAMP00000034870Uncharacterized protein. (48 aa)
STAG2Stromal antigen 2. (1189 aa)
CDC25BCell division cycle 25B. (559 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
SMC3Structural maintenance of chromosomes protein. (1215 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
CCNHCyclin H; Belongs to the cyclin family. (313 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
ORC3Origin recognition complex subunit 3. (526 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
WEE2Wee1-like protein kinase. (530 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
ENSUAMP00000015907Uncharacterized protein. (738 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
RB1RB transcriptional corepressor 1. (870 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CHEK2Checkpoint kinase 2. (530 aa)
FAM126BFamily with sequence similarity 126 member B. (293 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (425 aa)
ANAPC7Anaphase promoting complex subunit 7. (586 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1071 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
ENSUAMP00000011976WD_REPEATS_REGION domain-containing protein. (474 aa)
CDK20Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (346 aa)
ENSUAMP00000011840BTB domain-containing protein. (208 aa)
ENSUAMP00000011833C2H2-type domain-containing protein. (81 aa)
ZBTB46Zinc finger and BTB domain containing 46. (580 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3341 aa)
CDC27Cell division cycle 27. (729 aa)
CDC7Cell division cycle 7. (575 aa)
ENSUAMP00000010431Uncharacterized protein. (415 aa)
ENSUAMP00000010248Uncharacterized protein. (71 aa)
ZBTB47Zinc finger and BTB domain containing 47. (750 aa)
STAG1Stromal antigen 1. (1002 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
ENSUAMP00000009635Uncharacterized protein. (461 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (492 aa)
BUB3BUB3 mitotic checkpoint protein. (326 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
ENSUAMP0000000899414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (100 aa)
TTKTTK protein kinase. (853 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
WEE1Wee1-like protein kinase. (645 aa)
ENSUAMP00000007986Uncharacterized protein. (100 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (397 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (150 aa)
RAD21L1RAD21 cohesin complex component like 1. (554 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
TFDP1Transcription factor Dp-1. (477 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
ENSUAMP00000006884Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
ZBTB10Zinc finger and BTB domain containing 10. (873 aa)
TMEM82Transmembrane protein 82. (344 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
ENSUAMP00000004606Uncharacterized protein. (1041 aa)
E2F2E2F transcription factor 2. (431 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2101 aa)
ENSUAMP00000003531BTB domain-containing protein. (67 aa)
ENSUAMP00000003375Uncharacterized protein. (90 aa)
SMC1BStructural maintenance of chromosomes protein. (1194 aa)
ENSUAMP00000002920Uncharacterized protein. (80 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (447 aa)
ENSUAMP00000002462Uncharacterized protein. (120 aa)
ENSUAMP00000002455TPR_REGION domain-containing protein. (149 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (425 aa)
DBF4DBF4 zinc finger. (673 aa)
ENSUAMP00000001840Uncharacterized protein. (586 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (446 aa)
ENSUAMP00000001524Uncharacterized protein. (75 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CDC20Cell division cycle 20. (516 aa)
ENSUAMP00000000864Uncharacterized protein. (201 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
ENSUAMP00000000622Uncharacterized protein. (151 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
ENSUAMP00000000381Uncharacterized protein. (476 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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