136 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	SPDYA	Speedy/RINGO cell cycle regulator family member A. (311 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	FBXO43	F-box protein 43. (687 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	ENSUAMP00000027679	Uncharacterized protein. (51 aa)
	ANAPC2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (893 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	EFCAB3	EF-hand calcium binding domain 3. (436 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (742 aa)
	RPS6KA3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	ENSUAMP00000030716	Uncharacterized protein. (98 aa)
	ENSUAMP00000030741	Uncharacterized protein. (248 aa)
	SMC1A	Structural maintenance of chromosomes protein. (1239 aa)
	ANAPC4	Anaphase promoting complex subunit 4. (659 aa)
	RBX1	Ring-box 1. (108 aa)
	ENSUAMP00000031131	Protein kinase domain-containing protein. (264 aa)
	REC8	REC8 meiotic recombination protein. (482 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	FBXW11	F-box and WD repeat domain containing 11. (543 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	ENSUAMP00000032382	CaMKII_AD domain-containing protein. (189 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	ENSUAMP00000032533	Uncharacterized protein. (127 aa)
	ENSUAMP00000032535	Uncharacterized protein. (145 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (449 aa)
	ARSI	Arylsulfatase family member I. (573 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
	ENSUAMP00000034116	Uncharacterized protein. (571 aa)
	MOS	MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (349 aa)
	ENSUAMP00000034830	Uncharacterized protein. (1872 aa)
	SMC3	Structural maintenance of chromosomes protein. (1215 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (163 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	ANAPC13	Anaphase promoting complex subunit 13. (74 aa)
	TMEM82	Transmembrane protein 82. (344 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
	ENSUAMP00000005048	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (241 aa)
	CDK3	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2101 aa)
	ENSUAMP00000003375	Uncharacterized protein. (90 aa)
	ENSUAMP00000003358	SER_THR_PHOSPHATASE domain-containing protein. (106 aa)
	ENSUAMP00000003355	Uncharacterized protein. (76 aa)
	SMC1B	Structural maintenance of chromosomes protein. (1194 aa)
	ENSUAMP00000002920	Uncharacterized protein. (80 aa)
	ENSUAMP00000002888	Uncharacterized protein. (295 aa)
	SLK	STE20 like kinase. (1242 aa)
	ENSUAMP00000002462	Uncharacterized protein. (120 aa)
	ENSUAMP00000002455	TPR_REGION domain-containing protein. (149 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (425 aa)
	ENSUAMP00000002341	Uncharacterized protein. (957 aa)
	ENSUAMP00000001840	Uncharacterized protein. (586 aa)
	ENSUAMP00000001591	Uncharacterized protein. (65 aa)
	ENSUAMP00000001524	Uncharacterized protein. (75 aa)
	CDC20	Cell division cycle 20. (516 aa)
	ENSUAMP00000000864	Uncharacterized protein. (201 aa)
	PGR	Progesterone receptor. (634 aa)
	ENSUAMP00000000176	Protein kinase domain-containing protein. (82 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1288 aa)
	ANAPC5	Anaphase promoting complex subunit 5. (727 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (836 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
	CALML6	Calmodulin like 6. (180 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (586 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (710 aa)
	ENSUAMP00000013482	Uncharacterized protein. (91 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	AR	Androgen receptor. (905 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1071 aa)
	ENSUAMP00000012092	Uncharacterized protein. (589 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (307 aa)
	ENSUAMP00000011731	Ion_trans domain-containing protein. (408 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (753 aa)
	CDC27	Cell division cycle 27. (729 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (479 aa)
	ENSUAMP00000010248	Uncharacterized protein. (71 aa)
	FBXO5	F-box protein 5. (448 aa)
	MTRF1L	Mitochondrial translational release factor 1 like. (380 aa)
	PKMYT1	Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (492 aa)
	STAG3	Stromal antigen 3. (1224 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	ENSUAMP00000008994	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (100 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (370 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	CALML5	Calmodulin like 5. (156 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (317 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (397 aa)
	SKP1	S-phase kinase associated protein 1; Belongs to the SKP1 family. (150 aa)
	ENSUAMP00000007617	Protein kinase domain-containing protein. (271 aa)
	ENSUAMP00000006694	SER_THR_PHOSPHATASE domain-containing protein. (148 aa)
	PLCL2	Phosphoinositide phospholipase C. (1003 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	ENSUAMP00000018470	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	CDC16	Cell division cycle 16. (624 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (205 aa)
	ENSUAMP00000019174	CaMKII_AD domain-containing protein. (267 aa)
	ENSUAMP00000019181	Protein kinase domain-containing protein. (206 aa)
	CALML4	Calmodulin like 4. (153 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (589 aa)
	ANAPC1	APC1_C domain-containing protein. (1191 aa)
	PPP2R5A	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa)
	IGF1	Insulin like growth factor 1. (171 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (149 aa)
	ENSUAMP00000021561	RING-type domain-containing protein. (84 aa)
	ENSUAMP00000021954	Uncharacterized protein. (209 aa)
	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (601 aa)
	ENSUAMP00000022173	Uncharacterized protein. (86 aa)
	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (504 aa)
	PLCZ1	Phosphoinositide phospholipase C. (596 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa)
	ENSUAMP00000023102	Uncharacterized protein. (1102 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	ENSUAMP00000023307	Uncharacterized protein. (243 aa)
	CDC26	Cell division cycle 26. (85 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (503 aa)
	CDK1	Cyclin dependent kinase 1. (305 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	RPS6KA6	Non-specific serine/threonine protein kinase. (686 aa)
	ENSUAMP00000025311	Uncharacterized protein. (295 aa)
	ENSUAMP00000025726	annotation not available (113 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (656 aa)
	MAPK11	Mitogen-activated protein kinase. (357 aa)
	MAPK12	Mitogen-activated protein kinase 12. (373 aa)
	EFCAB13	EF-hand calcium binding domain 13. (939 aa)
	PPP2R5B	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSUAMP00000028025	ENSUAMP00000008551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY4	ENSUAMP00000028025	ENSUAMP00000032005	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	ADCY9	ENSUAMP00000028025	ENSUAMP00000005924	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.646
ADCY1	ANAPC5	ENSUAMP00000028025	ENSUAMP00000018417	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 5.	0.452
ADCY1	ANAPC7	ENSUAMP00000028025	ENSUAMP00000013583	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 7.	0.524
ADCY1	CALM2	ENSUAMP00000028025	ENSUAMP00000035625	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.848
ADCY1	CALM3	ENSUAMP00000028025	ENSUAMP00000021541	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.848
ADCY1	CALML4	ENSUAMP00000028025	ENSUAMP00000019475	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.930
ADCY1	CALML5	ENSUAMP00000028025	ENSUAMP00000008609	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.956
ADCY1	CALML6	ENSUAMP00000028025	ENSUAMP00000013788	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.957
ADCY1	CAMK2B	ENSUAMP00000028025	ENSUAMP00000019832	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.851
ADCY1	ENSUAMP00000000176	ENSUAMP00000028025	ENSUAMP00000000176	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000003375	ENSUAMP00000028025	ENSUAMP00000003375	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.452
ADCY1	ENSUAMP00000007617	ENSUAMP00000028025	ENSUAMP00000007617	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.875
ADCY1	ENSUAMP00000019174	ENSUAMP00000028025	ENSUAMP00000019174	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	CaMKII_AD domain-containing protein.	0.843
ADCY1	ENSUAMP00000019181	ENSUAMP00000028025	ENSUAMP00000019181	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.843