STRINGSTRING
CDK1 CDK1 SHISA5 SHISA5 APAF1 APAF1 HPS5 HPS5 RPRM RPRM FAM76A FAM76A ENSUAMP00000027429 ENSUAMP00000027429 ENSUAMP00000027431 ENSUAMP00000027431 RRM2 RRM2 ENSUAMP00000027975 ENSUAMP00000027975 ENSUAMP00000028080 ENSUAMP00000028080 CDKN1A CDKN1A PIDD1 PIDD1 GORAB GORAB CYCS CYCS C7orf31 C7orf31 BCL2L1 BCL2L1 ENSUAMP00000031131 ENSUAMP00000031131 TSC2 TSC2 SESN2 SESN2 GTSE1 GTSE1 CCND1 CCND1 ENSUAMP00000032923 ENSUAMP00000032923 CD82 CD82 TP53I3 TP53I3 SFN SFN CCNG2 CCNG2 ENSUAMP00000035027 ENSUAMP00000035027 SIAH2 SIAH2 GADD45A GADD45A RPRML RPRML PMAIP1 PMAIP1 CCNG1 CCNG1 CCND3 CCND3 ENSUAMP00000000381 ENSUAMP00000000381 TP53 TP53 SESN1 SESN1 ENSUAMP00000001524 ENSUAMP00000001524 CCNB1 CCNB1 ENSUAMP00000002778 ENSUAMP00000002778 DDB2 DDB2 AIFM2 AIFM2 ENSUAMP00000004535 ENSUAMP00000004535 CDK3 CDK3 ENSUAMP00000004964 ENSUAMP00000004964 ADGRB2 ADGRB2 ENSUAMP00000006884 ENSUAMP00000006884 STEAP3 STEAP3 EI24 EI24 CHEK1 CHEK1 CCNB2 CCNB2 CASP8 CASP8 CDK6 CDK6 MDM4 MDM4 CCNE1 CCNE1 ENSUAMP00000008823 ENSUAMP00000008823 ZMAT3 ZMAT3 ENSUAMP00000009491 ENSUAMP00000009491 ENSUAMP00000010407 ENSUAMP00000010407 ENSUAMP00000010408 ENSUAMP00000010408 SERPINE1 SERPINE1 SIVA1 SIVA1 ENSUAMP00000011147 ENSUAMP00000011147 BCL2 BCL2 ENSUAMP00000012356 ENSUAMP00000012356 BAX BAX BID BID CRYZ CRYZ CHEK2 CHEK2 TP73 TP73 SERPINB5 SERPINB5 ENSUAMP00000016311 ENSUAMP00000016311 CDK4 CDK4 GADD45B GADD45B SMIM41 SMIM41 ENSUAMP00000018082 ENSUAMP00000018082 FAM76B FAM76B ENSUAMP00000018470 ENSUAMP00000018470 CASP3 CASP3 SESN3 SESN3 GADD45G GADD45G IGF1 IGF1 THBS1 THBS1 RCHY1 RCHY1 CASP9 CASP9 ENSUAMP00000023031 ENSUAMP00000023031 ENSUAMP00000023482 ENSUAMP00000023482 ENSUAMP00000023487 ENSUAMP00000023487 MDM2 MDM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK1Cyclin dependent kinase 1. (305 aa)
SHISA5Shisa family member 5. (238 aa)
APAF1Apoptotic peptidase activating factor 1. (948 aa)
HPS5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1095 aa)
RPRMReprimo, TP53 dependent G2 arrest mediator homolog. (109 aa)
FAM76AFamily with sequence similarity 76 member A. (288 aa)
ENSUAMP00000027429Uncharacterized protein. (165 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (297 aa)
ENSUAMP00000027975Thyroglobulin type-1 domain-containing protein. (102 aa)
ENSUAMP00000028080Uncharacterized protein. (291 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PIDD1P53-induced death domain protein 1. (911 aa)
GORABGolgin, RAB6 interacting. (399 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
C7orf31Chromosome 7 open reading frame 31. (575 aa)
BCL2L1BCL2 like 1. (233 aa)
ENSUAMP00000031131Protein kinase domain-containing protein. (264 aa)
TSC2TSC complex subunit 2. (1614 aa)
SESN2Sestrin 2. (463 aa)
GTSE1G2 and S-phase expressed 1. (722 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
CD82Tetraspanin. (255 aa)
TP53I3Tumor protein p53 inducible protein 3. (304 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (343 aa)
ENSUAMP00000035027Uncharacterized protein. (146 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (325 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (150 aa)
RPRMLReprimo like. (120 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
ENSUAMP00000000381Uncharacterized protein. (476 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SESN1Sestrin 1. (492 aa)
ENSUAMP00000001524Uncharacterized protein. (75 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (425 aa)
ENSUAMP00000002778E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
DDB2Damage specific DNA binding protein 2. (421 aa)
AIFM2Apoptosis inducing factor mitochondria associated 2. (373 aa)
ENSUAMP00000004535E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1593 aa)
ENSUAMP00000006884Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
STEAP3STEAP3 metalloreductase. (521 aa)
EI24EI24 autophagy associated transmembrane protein. (340 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (397 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
ZMAT3Zinc finger matrin-type 3. (289 aa)
ENSUAMP00000009491C2 tensin-type domain-containing protein. (179 aa)
ENSUAMP00000010407PPM-type phosphatase domain-containing protein. (179 aa)
ENSUAMP00000010408PPM-type phosphatase domain-containing protein. (239 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
ENSUAMP00000011147Ion_trans domain-containing protein. (118 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
ENSUAMP00000012356Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (635 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (196 aa)
CRYZCrystallin zeta. (330 aa)
CHEK2Checkpoint kinase 2. (530 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (182 aa)
SMIM41Small integral membrane protein 41. (91 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
FAM76BFamily with sequence similarity 76 member B. (210 aa)
ENSUAMP00000018470Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
SESN3Sestrin 3. (492 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (228 aa)
IGF1Insulin like growth factor 1. (171 aa)
THBS1Thrombospondin 1. (1170 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
ENSUAMP00000023031Uncharacterized protein. (118 aa)
ENSUAMP00000023482G_PROTEIN_RECEP_F2_3 domain-containing protein. (915 aa)
ENSUAMP00000023487G_PROTEIN_RECEP_F2_4 domain-containing protein. (454 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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