STRINGSTRING
PPP2CB PPP2CB ADRA1A ADRA1A PPP2R2C PPP2R2C ENSUAMP00000001879 ENSUAMP00000001879 CPT1B CPT1B PPARG PPARG CCNA1 CCNA1 ENSUAMP00000002904 ENSUAMP00000002904 AKT1S1 AKT1S1 RHEB RHEB IRS4 IRS4 RAB14 RAB14 ENSUAMP00000003524 ENSUAMP00000003524 ENSUAMP00000003542 ENSUAMP00000003542 GYS2 GYS2 FOXO1 FOXO1 RPS6KB2 RPS6KB2 CAB39L CAB39L ENSUAMP00000006800 ENSUAMP00000006800 MLYCD MLYCD ENSUAMP00000007256 ENSUAMP00000007256 ENSUAMP00000008512 ENSUAMP00000008512 STRADA STRADA CPT1C CPT1C PIK3CA PIK3CA CFTR CFTR ENSUAMP00000009785 ENSUAMP00000009785 PIK3R1 PIK3R1 AKT1 AKT1 GAREM2 GAREM2 RAB10 RAB10 FBP2 FBP2 ENSUAMP00000011272 ENSUAMP00000011272 ENSUAMP00000011275 ENSUAMP00000011275 ENSUAMP00000011307 ENSUAMP00000011307 AKT3 AKT3 PPP2R2D PPP2R2D FOXO3 FOXO3 FOXO3B FOXO3B HMGCR HMGCR STRADB STRADB PPP2R1A PPP2R1A ACACB ACACB GYS1 GYS1 SREBF1 SREBF1 PFKM PFKM LIPE LIPE CCNA2 CCNA2 ENSUAMP00000014171 ENSUAMP00000014171 IRS2 IRS2 ENSUAMP00000014875 ENSUAMP00000014875 ENSUAMP00000014981 ENSUAMP00000014981 IGF1R IGF1R PPP2R5B PPP2R5B PRKAA2 PRKAA2 ENSUAMP00000015938 ENSUAMP00000015938 ENSUAMP00000016357 ENSUAMP00000016357 PDPK1 PDPK1 G6PC G6PC ENSUAMP00000016618 ENSUAMP00000016618 ENSUAMP00000016622 ENSUAMP00000016622 ENSUAMP00000017347 ENSUAMP00000017347 ENSUAMP00000017349 ENSUAMP00000017349 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 ENSUAMP00000018097 ENSUAMP00000018097 SLC2A4 SLC2A4 ENSUAMP00000018670 ENSUAMP00000018670 PPP2R3A PPP2R3A MTOR MTOR PIK3CD PIK3CD ADIPOQ ADIPOQ PPP2R5A PPP2R5A PFKFB1 PFKFB1 IGF1 IGF1 PPP2R2B PPP2R2B SIRT1 SIRT1 HNF4A HNF4A ULK1 ULK1 ENSUAMP00000022131 ENSUAMP00000022131 PPP2R5D PPP2R5D LEP LEP PPP2R5E PPP2R5E ADIPOR2 ADIPOR2 RPS6KB1 RPS6KB1 PFKFB3 PFKFB3 PFKP PFKP INSR INSR ADIPOR1 ADIPOR1 RAB2A RAB2A PPP2CA PPP2CA CREB1 CREB1 PPP2R5C PPP2R5C SCD SCD PFKFB4 PFKFB4 ENSUAMP00000024427 ENSUAMP00000024427 CREB3L3 CREB3L3 ENSUAMP00000024714 ENSUAMP00000024714 ENSUAMP00000025004 ENSUAMP00000025004 PCK1 PCK1 PPP2R2A PPP2R2A ENSUAMP00000026643 ENSUAMP00000026643 CREB5 CREB5 INS INS PPARGC1A PPARGC1A PFKFB2 PFKFB2 LEPR LEPR PRKAG3 PRKAG3 PRKAB2 PRKAB2 ELAVL1 ELAVL1 IRS1 IRS1 EEF2K EEF2K PPP2R3C PPP2R3C EIF4EBP1 EIF4EBP1 ENSUAMP00000030716 ENSUAMP00000030716 EEF2 EEF2 PCK2 PCK2 ENSUAMP00000031850 ENSUAMP00000031850 CREB3L4 CREB3L4 TSC2 TSC2 MAP3K7 MAP3K7 PFKL PFKL TBC1D1 TBC1D1 TSC1 TSC1 CCND1 CCND1 ENSUAMP00000032533 ENSUAMP00000032533 ENSUAMP00000032535 ENSUAMP00000032535 CPT1A CPT1A FASN FASN ENSUAMP00000032843 ENSUAMP00000032843 PRKAA1 PRKAA1 CAB39 CAB39 ENSUAMP00000034960 ENSUAMP00000034960 CREB3L1 CREB3L1 ENSUAMP00000035331 ENSUAMP00000035331 CREB3 CREB3 RHEBL1 RHEBL1 PRKAG1 PRKAG1 ENSUAMP00000036260 ENSUAMP00000036260 ENSUAMP00000037274 ENSUAMP00000037274 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ADRA1AAdrenoceptor alpha 1A. (319 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (425 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (447 aa)
ENSUAMP00000002904Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
AKT1S1AKT1 substrate 1. (324 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
IRS4Insulin receptor substrate 4. (1256 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
ENSUAMP00000003524PFK domain-containing protein. (53 aa)
ENSUAMP00000003542annotation not available (356 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (708 aa)
FOXO1Forkhead box O1. (660 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
CAB39LCalcium binding protein 39 like. (337 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
MLYCDMalonyl-CoA decarboxylase. (500 aa)
ENSUAMP00000007256Uncharacterized protein. (73 aa)
ENSUAMP00000008512Biotin carboxylation domain-containing protein. (206 aa)
STRADASTE20 related adaptor alpha. (373 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
ENSUAMP00000009785Uncharacterized protein; Belongs to the CD36 family. (215 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (808 aa)
RAB10RAB10, member RAS oncogene family. (194 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (319 aa)
ENSUAMP00000011272FBPase domain-containing protein; Belongs to the FBPase class 1 family. (293 aa)
ENSUAMP00000011275FBPase domain-containing protein. (57 aa)
ENSUAMP00000011307Uncharacterized protein. (1315 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (897 aa)
STRADBSTE20 related adaptor beta. (410 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ACACBAcetyl-CoA carboxylase beta. (2045 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
PFKMUncharacterized protein. (862 aa)
LIPELipase E, hormone sensitive type. (805 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (425 aa)
ENSUAMP00000014171PFK domain-containing protein. (309 aa)
IRS2Insulin receptor substrate 2. (1089 aa)
ENSUAMP00000014875Uncharacterized protein. (837 aa)
ENSUAMP00000014981EF-hand domain-containing protein. (176 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PRKAA2Non-specific serine/threonine protein kinase. (525 aa)
ENSUAMP00000015938Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (134 aa)
ENSUAMP00000016357Uncharacterized protein. (330 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (223 aa)
ENSUAMP00000016618Protein kinase domain-containing protein. (317 aa)
ENSUAMP00000016622Uncharacterized protein. (246 aa)
ENSUAMP00000017347Uncharacterized protein. (64 aa)
ENSUAMP00000017349Uncharacterized protein. (125 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
ENSUAMP00000018097Uncharacterized protein. (69 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ENSUAMP00000018670Uncharacterized protein. (72 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1153 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (490 aa)
IGF1Insulin like growth factor 1. (171 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
SIRT1Sirtuin 1. (618 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ULK1Unc-51 like autophagy activating kinase 1. (974 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (601 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (157 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (504 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (544 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (803 aa)
INSRTyrosine-protein kinase receptor. (1072 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
RAB2ARAB2A, member RAS oncogene family. (166 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (503 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (485 aa)
ENSUAMP00000024427Recep_L_domain domain-containing protein. (297 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
ENSUAMP00000024714annotation not available (356 aa)
ENSUAMP00000025004Uncharacterized protein; Belongs to the CD36 family. (96 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (458 aa)
ENSUAMP00000026643Uncharacterized protein. (232 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (472 aa)
LEPRLeptin receptor. (1166 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (491 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (286 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (344 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
EEF2KEukaryotic elongation factor 2 kinase. (723 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (450 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
ENSUAMP00000030716Uncharacterized protein. (98 aa)
EEF2Eukaryotic translation elongation factor 2. (860 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
ENSUAMP00000031850TORC_C domain-containing protein. (261 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
TSC2TSC complex subunit 2. (1614 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PFKLPhosphofructokinase, liver type. (577 aa)
TBC1D1TBC1 domain family member 1. (1187 aa)
TSC1TSC complex subunit 1. (1168 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
ENSUAMP00000032533Uncharacterized protein. (127 aa)
ENSUAMP00000032535Uncharacterized protein. (145 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
FASNFatty acid synthase. (2519 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CAB39Calcium binding protein 39. (341 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
RHEBL1RHEB like 1. (183 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
ENSUAMP00000036260Uncharacterized protein. (1033 aa)
ENSUAMP00000037274Uncharacterized protein. (439 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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