STRINGSTRING
AKT2 AKT2 TP53 TP53 SESN1 SESN1 KL KL ENSUAMP00000001879 ENSUAMP00000001879 PPARG PPARG AKT1S1 AKT1S1 RHEB RHEB IRS4 IRS4 ENSUAMP00000003693 ENSUAMP00000003693 FOXO1 FOXO1 ATF4 ATF4 ADCY9 ADCY9 RPS6KB2 RPS6KB2 ENSUAMP00000006800 ENSUAMP00000006800 ENSUAMP00000006876 ENSUAMP00000006876 ADCY2 ADCY2 ADCY3 ADCY3 PIK3CA PIK3CA CAT CAT ATF2 ATF2 PIK3R1 PIK3R1 AKT1 AKT1 AKT3 AKT3 FOXO3 FOXO3 FOXO3B FOXO3B ENSUAMP00000012831 ENSUAMP00000012831 BAX BAX ERAS ERAS IRS2 IRS2 ENSUAMP00000014875 ENSUAMP00000014875 IGF1R IGF1R PRKAA2 PRKAA2 ENSUAMP00000015993 ENSUAMP00000015993 ENSUAMP00000016357 ENSUAMP00000016357 ENSUAMP00000016618 ENSUAMP00000016618 ENSUAMP00000016622 ENSUAMP00000016622 EIF4E EIF4E ENSUAMP00000017347 ENSUAMP00000017347 ENSUAMP00000017349 ENSUAMP00000017349 ENSUAMP00000017435 ENSUAMP00000017435 ATG101 ATG101 ENSUAMP00000017692 ENSUAMP00000017692 MTOR MTOR PIK3CD PIK3CD ADIPOQ ADIPOQ ENSUAMP00000020485 ENSUAMP00000020485 SESN3 SESN3 ATF6B ATF6B KRAS KRAS IGF1 IGF1 RB1CC1 RB1CC1 NFKB1 NFKB1 SIRT1 SIRT1 ULK1 ULK1 ENSUAMP00000022131 ENSUAMP00000022131 ADIPOR2 ADIPOR2 RPS6KB1 RPS6KB1 INSR INSR ADIPOR1 ADIPOR1 ENSUAMP00000023165 ENSUAMP00000023165 ENSUAMP00000023419 ENSUAMP00000023419 ENSUAMP00000023422 ENSUAMP00000023422 CREB1 CREB1 ENSUAMP00000024427 ENSUAMP00000024427 CREB3L3 CREB3L3 ATG5 ATG5 TBCA TBCA EIF4E2 EIF4E2 ENSUAMP00000026643 ENSUAMP00000026643 CREB5 CREB5 RELA RELA ENSUAMP00000026993 ENSUAMP00000026993 INS INS PPARGC1A PPARGC1A PRKAG3 PRKAG3 ADCY5 ADCY5 ADCY1 ADCY1 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 PRKAB2 PRKAB2 EIF4E1B EIF4E1B IRS1 IRS1 EIF4EBP1 EIF4EBP1 ENSUAMP00000031719 ENSUAMP00000031719 CREB3L4 CREB3L4 TSC2 TSC2 EHMT2 EHMT2 ADCY4 ADCY4 SESN2 SESN2 ADCY7 ADCY7 TSC1 TSC1 ENSUAMP00000032843 ENSUAMP00000032843 PRKAA1 PRKAA1 PRKACB PRKACB ATG13 ATG13 ENSUAMP00000034960 ENSUAMP00000034960 CREB3L1 CREB3L1 ENSUAMP00000035331 ENSUAMP00000035331 CREB3 CREB3 RHEBL1 RHEBL1 PRKAG1 PRKAG1 ADCY6 ADCY6 APPL1 APPL1 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000037274 ENSUAMP00000037274
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SESN1Sestrin 1. (492 aa)
KLKlotho; Belongs to the glycosyl hydrolase 1 family. (705 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
AKT1S1AKT1 substrate 1. (324 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
IRS4Insulin receptor substrate 4. (1256 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
FOXO1Forkhead box O1. (660 aa)
ATF4Activating transcription factor 4. (351 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
ENSUAMP00000006876Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (187 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
ENSUAMP00000012831Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (259 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
ERASES cell expressed Ras. (219 aa)
IRS2Insulin receptor substrate 2. (1089 aa)
ENSUAMP00000014875Uncharacterized protein. (837 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
PRKAA2Non-specific serine/threonine protein kinase. (525 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
ENSUAMP00000016357Uncharacterized protein. (330 aa)
ENSUAMP00000016618Protein kinase domain-containing protein. (317 aa)
ENSUAMP00000016622Uncharacterized protein. (246 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (180 aa)
ENSUAMP00000017347Uncharacterized protein. (64 aa)
ENSUAMP00000017349Uncharacterized protein. (125 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ATG101Autophagy related 101. (218 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ENSUAMP00000020485Protein kinase domain-containing protein. (108 aa)
SESN3Sestrin 3. (492 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
IGF1Insulin like growth factor 1. (171 aa)
RB1CC1RB1 inducible coiled-coil 1. (1273 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
SIRT1Sirtuin 1. (618 aa)
ULK1Unc-51 like autophagy activating kinase 1. (974 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
INSRTyrosine-protein kinase receptor. (1072 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
ENSUAMP00000023165Protein kinase domain-containing protein. (270 aa)
ENSUAMP00000023419SET domain-containing protein. (162 aa)
ENSUAMP00000023422ANK_REP_REGION domain-containing protein. (975 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSUAMP00000024427Recep_L_domain domain-containing protein. (297 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (107 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
ENSUAMP00000026643Uncharacterized protein. (232 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (491 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (286 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (225 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
TSC2TSC complex subunit 2. (1614 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1294 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
SESN2Sestrin 2. (463 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
TSC1TSC complex subunit 1. (1168 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ATG13Autophagy related 13. (550 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
RHEBL1RHEB like 1. (183 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (665 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000037274Uncharacterized protein. (439 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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