STRINGSTRING
HDAC2 HDAC2 AKT1S1 AKT1S1 IRS4 IRS4 ENSUAMP00000003693 ENSUAMP00000003693 FOXO1 FOXO1 ADCY9 ADCY9 RPS6KB2 RPS6KB2 ADCY2 ADCY2 ADCY3 ADCY3 PIK3CA PIK3CA CAT CAT EIF4EBP2 EIF4EBP2 PIK3R1 PIK3R1 AKT1 AKT1 SOD1 SOD1 AKT3 AKT3 FOXO3 FOXO3 FOXO3B FOXO3B ENSUAMP00000012831 ENSUAMP00000012831 SOD3 SOD3 ERAS ERAS IRS2 IRS2 FOXA1 FOXA1 ENSUAMP00000014875 ENSUAMP00000014875 IGF1R IGF1R FOXA2 FOXA2 PRKAA2 PRKAA2 ENSUAMP00000015993 ENSUAMP00000015993 ENSUAMP00000016357 ENSUAMP00000016357 ENSUAMP00000017347 ENSUAMP00000017347 ENSUAMP00000017349 ENSUAMP00000017349 ENSUAMP00000017435 ENSUAMP00000017435 ENSUAMP00000017692 ENSUAMP00000017692 HDAC1 HDAC1 MTOR MTOR PIK3CD PIK3CD KRAS KRAS IGF1 IGF1 SIRT1 SIRT1 ENSUAMP00000022131 ENSUAMP00000022131 RPS6KB1 RPS6KB1 INSR INSR ENSUAMP00000023720 ENSUAMP00000023720 CRYAB CRYAB ENSUAMP00000024427 ENSUAMP00000024427 ATG5 ATG5 HSPA2 HSPA2 ENSUAMP00000026643 ENSUAMP00000026643 ENSUAMP00000026993 ENSUAMP00000026993 ENSUAMP00000001165 ENSUAMP00000001165 INS INS TIMM8A TIMM8A PRKAG3 PRKAG3 ADCY5 ADCY5 ADCY1 ADCY1 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 PRKAB2 PRKAB2 HSPA8 HSPA8 IRS1 IRS1 CLPB CLPB ENSUAMP00000031719 ENSUAMP00000031719 ENSUAMP00000031983 ENSUAMP00000031983 ADCY4 ADCY4 ADCY7 ADCY7 PRKAA1 PRKAA1 KCNK1 KCNK1 PRKACB PRKACB ENSUAMP00000035331 ENSUAMP00000035331 PRKAG1 PRKAG1 ADCY6 ADCY6 ENSUAMP00000036324 ENSUAMP00000036324 ENSUAMP00000037274 ENSUAMP00000037274 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (446 aa)
AKT1S1AKT1 substrate 1. (324 aa)
IRS4Insulin receptor substrate 4. (1256 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
FOXO1Forkhead box O1. (660 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
ENSUAMP00000012831Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (259 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (247 aa)
ERASES cell expressed Ras. (219 aa)
IRS2Insulin receptor substrate 2. (1089 aa)
FOXA1Forkhead box A1. (472 aa)
ENSUAMP00000014875Uncharacterized protein. (837 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
FOXA2Forkhead box A2. (465 aa)
PRKAA2Non-specific serine/threonine protein kinase. (525 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
ENSUAMP00000016357Uncharacterized protein. (330 aa)
ENSUAMP00000017347Uncharacterized protein. (64 aa)
ENSUAMP00000017349Uncharacterized protein. (125 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
IGF1Insulin like growth factor 1. (171 aa)
SIRT1Sirtuin 1. (618 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
INSRTyrosine-protein kinase receptor. (1072 aa)
ENSUAMP00000023720zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (255 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ENSUAMP00000024427Recep_L_domain domain-containing protein. (297 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (611 aa)
ENSUAMP00000026643Uncharacterized protein. (232 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
ENSUAMP00000001165Uncharacterized protein. (96 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
TIMM8ATranslocase of inner mitochondrial membrane 8A; Belongs to the small Tim family. (97 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (491 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (286 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (677 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
ENSUAMP00000031983Uncharacterized protein; Belongs to the heat shock protein 70 family. (653 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
KCNK1Potassium two pore domain channel subfamily K member 1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (331 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
ENSUAMP00000037274Uncharacterized protein. (439 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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