STRINGSTRING
ENSUAMP00000001754 ENSUAMP00000001754 ENSUAMP00000001268 ENSUAMP00000001268 TP53 TP53 LTF LTF ENSUAMP00000000802 ENSUAMP00000000802 ENSUAMP00000000674 ENSUAMP00000000674 PGPEP1 PGPEP1 LPCAT3 LPCAT3 STEAP3 STEAP3 ENSUAMP00000007127 ENSUAMP00000007127 ATG7 ATG7 ENSUAMP00000007377 ENSUAMP00000007377 ENSUAMP00000007383 ENSUAMP00000007383 PCBP3 PCBP3 CP CP ENSUAMP00000009856 ENSUAMP00000009856 ENSUAMP00000011146 ENSUAMP00000011146 GPX4 GPX4 ENSUAMP00000013215 ENSUAMP00000013215 SLC40A1 SLC40A1 ALOX15 ALOX15 GSS GSS SLC11A2 SLC11A2 SLC39A14 SLC39A14 ENSUAMP00000018915 ENSUAMP00000018915 HMOX1 HMOX1 ENSUAMP00000003472 ENSUAMP00000003472 SLC39A8 SLC39A8 ENSUAMP00000020080 ENSUAMP00000020080 VDAC3 VDAC3 FTMT FTMT ACSL3 ACSL3 SLC3A2 SLC3A2 ENSUAMP00000021840 ENSUAMP00000021840 ENSUAMP00000021940 ENSUAMP00000021940 ENSUAMP00000022383 ENSUAMP00000022383 ENSUAMP00000023108 ENSUAMP00000023108 TF TF ENSUAMP00000023390 ENSUAMP00000023390 ACSL1 ACSL1 SLC7A11 SLC7A11 ATG5 ATG5 ENSUAMP00000024692 ENSUAMP00000024692 ENSUAMP00000026267 ENSUAMP00000026267 ENSUAMP00000026668 ENSUAMP00000026668 PCBP4 PCBP4 MAP1LC3A MAP1LC3A SAT1 SAT1 ENSUAMP00000027456 ENSUAMP00000027456 ENSUAMP00000028182 ENSUAMP00000028182 ENSUAMP00000030630 ENSUAMP00000030630 ENSUAMP00000031046 ENSUAMP00000031046 MELTF MELTF PCBP2 PCBP2 XK XK CYBB CYBB GCLC GCLC ENSUAMP00000034850 ENSUAMP00000034850 XKRX XKRX ENSUAMP00000035546 ENSUAMP00000035546 ACSL4 ACSL4 GCLM GCLM TFR2 TFR2 TFRC TFRC ENSUAMP00000002329 ENSUAMP00000002329 ENSUAMP00000002281 ENSUAMP00000002281 ENSUAMP00000002989 ENSUAMP00000002989 ENSUAMP00000003842 ENSUAMP00000003842 PRNP PRNP ENSUAMP00000006295 ENSUAMP00000006295
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000001754Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (254 aa)
ENSUAMP00000001268Uncharacterized protein. (244 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LTFLactotransferrin; Belongs to the transferrin family. (706 aa)
ENSUAMP00000000802Uncharacterized protein. (67 aa)
ENSUAMP00000000674Uncharacterized protein. (258 aa)
PGPEP1Pyroglutamyl-peptidase I. (209 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (477 aa)
STEAP3STEAP3 metalloreductase. (521 aa)
ENSUAMP00000007127Uncharacterized protein. (73 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (625 aa)
ENSUAMP00000007377Uncharacterized protein. (163 aa)
ENSUAMP00000007383Uncharacterized protein. (159 aa)
PCBP3Poly(rC) binding protein 3. (363 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1116 aa)
ENSUAMP00000009856Uncharacterized protein. (79 aa)
ENSUAMP00000011146ARA70 domain-containing protein. (110 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (178 aa)
ENSUAMP00000013215Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (576 aa)
ALOX15Arachidonate 15-lipoxygenase. (672 aa)
GSSGlutathione synthetase. (536 aa)
SLC11A2Solute carrier family 11 member 2. (533 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
ENSUAMP00000018915AMP-binding domain-containing protein. (730 aa)
HMOX1Heme oxygenase 1. (288 aa)
ENSUAMP00000003472Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (125 aa)
SLC39A8Solute carrier family 39 member 8. (283 aa)
ENSUAMP00000020080Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (113 aa)
VDAC3Voltage dependent anion channel 3. (279 aa)
FTMTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (243 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (659 aa)
SLC3A2Solute carrier family 3 member 2. (545 aa)
ENSUAMP00000021840Plastocyanin-like domain-containing protein. (789 aa)
ENSUAMP00000021940Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ENSUAMP00000022383N-acetyltransferase domain-containing protein. (96 aa)
ENSUAMP00000023108Uncharacterized protein; Belongs to the transferrin family. (600 aa)
TFTransferrin; Belongs to the transferrin family. (709 aa)
ENSUAMP00000023390Uncharacterized protein. (286 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (436 aa)
SLC7A11Solute carrier family 7 member 11. (466 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ENSUAMP00000024692Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ENSUAMP00000026267Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ENSUAMP00000026668Uncharacterized protein. (112 aa)
PCBP4Poly(rC) binding protein 4. (386 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (105 aa)
SAT1Spermidine/spermine N1-acetyltransferase 1. (173 aa)
ENSUAMP00000027456ATG7_N domain-containing protein. (72 aa)
ENSUAMP00000028182Uncharacterized protein. (128 aa)
ENSUAMP00000030630Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
ENSUAMP00000031046Uncharacterized protein. (68 aa)
MELTFMelanotransferrin. (795 aa)
PCBP2Poly(rC) binding protein 2. (366 aa)
XKXK-related protein. (433 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (576 aa)
ENSUAMP00000034850Uncharacterized protein. (294 aa)
XKRXXK-related protein. (449 aa)
ENSUAMP00000035546Uncharacterized protein. (70 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (515 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (278 aa)
TFR2Transferrin receptor 2. (592 aa)
TFRCTransferrin receptor. (779 aa)
ENSUAMP00000002329Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (90 aa)
ENSUAMP00000002281Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ENSUAMP00000002989Transferrin-like domain-containing protein. (113 aa)
ENSUAMP00000003842Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (160 aa)
PRNPMajor prion protein; Belongs to the prion family. (258 aa)
ENSUAMP00000006295Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (162 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.